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“…This attachment is extremely strong in the vitreous base since the fibrils pass through the ILM to merge into underlying collagen networks and crypts [2,56,57]. Collagen is also a significant component of both epiretinal and subretinal PVR membranes [53,58], and type I collagen is recognized to be a principal constituent during their early development [51][52][53]. The presence of collagen in the subretinal space, a place normally devoid of this protein, suggests that certain cells, particularly the RPE and Müller cells associated with membranes, are able to synthesize collagen under certain pathological conditions such as retinal detachment and PVR [58][59][60][61].…”
Section: Collagen-imentioning
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“…This attachment is extremely strong in the vitreous base since the fibrils pass through the ILM to merge into underlying collagen networks and crypts [2,56,57]. Collagen is also a significant component of both epiretinal and subretinal PVR membranes [53,58], and type I collagen is recognized to be a principal constituent during their early development [51][52][53]. The presence of collagen in the subretinal space, a place normally devoid of this protein, suggests that certain cells, particularly the RPE and Müller cells associated with membranes, are able to synthesize collagen under certain pathological conditions such as retinal detachment and PVR [58][59][60][61].…”
Section: Collagen-imentioning
“…Collagen is also a significant component of both epiretinal and subretinal PVR membranes [53,58], and type I collagen is recognized to be a principal constituent during their early development [51][52][53]. The presence of collagen in the subretinal space, a place normally devoid of this protein, suggests that certain cells, particularly the RPE and Müller cells associated with membranes, are able to synthesize collagen under certain pathological conditions such as retinal detachment and PVR [58][59][60][61]. However, the present analysis suggests collagen-I 1 fragment to be found in sham vitreous, which furthermore showed a decreased concentration following retinal detachment that may indicate perturbed proteolytic activity.…”
Section: Collagen-imentioning