Biomimetic Approaches for Biomaterials Development 2012
DOI: 10.1002/9783527652273.ch3
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Collagen‐Based Biomaterials for Regenerative Medicine

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Cited by 2 publications
(3 citation statements)
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“…The decellularization process is intended to remove cellular materials from tissue to render the resultant ECM scaffold compatible with implantation in an immunocompetent host, , whereas the solubilization of the acellular ECM must retain the type I collagen triple helix structure. This task is accomplished using diluted acid assisted with pepsin, which is responsible for removing telopeptides, which decrease the immunogenicity of collagen. ,, The use of different tissues requires the use of decellularization and extraction methods that can impact differentially composition and properties of the resulting ECM gel. Table compares several types of ECM hydrogels in terms of the tissue of origin, the biochemical composition, the processing conditions, and the main results in TERM studies.…”
Section: Processing–property Relationship In Decellularized Ecm Hydro...mentioning
confidence: 99%
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“…The decellularization process is intended to remove cellular materials from tissue to render the resultant ECM scaffold compatible with implantation in an immunocompetent host, , whereas the solubilization of the acellular ECM must retain the type I collagen triple helix structure. This task is accomplished using diluted acid assisted with pepsin, which is responsible for removing telopeptides, which decrease the immunogenicity of collagen. ,, The use of different tissues requires the use of decellularization and extraction methods that can impact differentially composition and properties of the resulting ECM gel. Table compares several types of ECM hydrogels in terms of the tissue of origin, the biochemical composition, the processing conditions, and the main results in TERM studies.…”
Section: Processing–property Relationship In Decellularized Ecm Hydro...mentioning
confidence: 99%
“…is responsible for removing telopeptides, which decrease the immunogenicity of collagen. 31,35,60 The use of different tissues requires the use of decellularization and extraction methods that can impact differentially composition and properties of the resulting ECM gel. Table 2 compares several types of ECM hydrogels in terms of the tissue of origin, the biochemical composition, the processing conditions, and the main results in TERM studies.…”
Section: Decellularized Ecm Hydrogelsmentioning
confidence: 99%
“…Hence, the implantation of biomaterials to treat bone disease or trauma appears promising. Bone substitutes need to have some specifications such as a good reliance on loading and a porous network to favour cell infiltration [7]. Nowadays, the research is towards the association of biomolecules with implants with the aim of enhancing osteointegration, promoting bone tissue repair or preventing infection [6].…”
Section: Bone Substitutesmentioning
confidence: 99%