Collaborative WHO xylitol field studies in Hungary I. Three-year caries activity in institutionalized children

Scheinin, Arje; Bánóczy, J; Szöke, J; Esztári, I; Pienihäkkinen, Kaisu; Scheinin, Ulla; Tiekso, Jaakko; Zimmermann, Peter; Hadas, E

doi:10.3109/00016358509046517

Cited by 57 publications

(50 citation statements)

References 19 publications

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“…Therefore, the value of the study re sides rather in the confirmation of a cariostatic poten tial of xylitol when used as a sugar substitute under realistic conditions. The magnitude of the apparent effect of sugar substitution was clinically relevant un der the conditions of the present trial and in agree ment with results from similar investigations [Schei nin and Banoczy, 1985]. Therefore, partial substitu tion of sugar with xylitol may be a valuable approach to caries prevention when used in addition to fluoride and regular oral hygiene.…”

Section: Discussionsupporting

confidence: 77%

Collaborative WHO Xylitol Field Study in French Polynesia

Kandelman

Bär²,

Hefti

1988

Caries Res

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The value for caries prevention of partial sugar substitution by xylitol was tested in a 32-month nonrandomized comparative field study. A total of 746 6- to 12-year-old children living on three islands of the Polynesian archipelago were enrolled in the study. The children of one island representing the control group were supplied with toothbrushes and fluoridated dentifrice, and received regular instruction on oral hygiene. Otherwise, they maintained their customary dietary habits. The children of the other two islands were assigned to the xylitol group. They were enrolled in an identical oral health programme but, in addition, were regularly provided with xylitol-based sweets, i.e. chewing gums, candies, chocolate, ice lollies and gumdrops, at school on a daily basis in amounts corresponding to not more than 20 g xylitol/day. 468 children completed the study. The 195 participants of the control group showed an overall mean caries increment of 7.1 DMFS. In the xylitol group with 273 children a mean caries increment of 4.5 DMFS was measured. It is concluded that partial sugar substitution by xylitol is a useful tool in preventing caries and should be considered in addition to fluoridation and oral hygiene measures in public oral health programmes.

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Section: Discussionsupporting

confidence: 77%

Collaborative WHO Xylitol Field Study in French Polynesia

Kandelman

Bär²,

Hefti

1988

Caries Res

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“…The reversals were already reported in the Turku Sugar Studies [Scheinin and Mäkinen, 1975], and they seemed to also appear in this field study. The remineralization effect of xylitol has been reported in several clinical studies [Scheinin and Mäkinen, 1975;Galliunin, 1981;Scheinin et al, 1985;Kandelman et al, 1988;Isokangas et al, 1989;Kandelman and Gagnon, 1990;Mäkinen et al, 1995b] and documented by clinical photographs on advanced dentinal caries lesions by Mäkinen et al [1995b].…”

Section: Discussionmentioning

confidence: 99%

Field Trial on Caries Prevention with Xylitol Candies among Disabled School Students

Honkala

Shyama

et al. 2006

Caries Res

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Background: In a 1999 survey high caries levels were found among physically disabled school students in Kuwait. Objectives: A field study was planned to test the efficacy of xylitol candies in preventing caries among individuals in two special schools in Kuwait. Methods: Altogether 176 students were examined in 2002 and 145 (105 in xylitol group and 40 in the control group) after 18 months’ intervention. The WHO criteria were used in recording caries according to surfaces (third molars were excluded) by 2 calibrated examiners (E.H., M.S.). The students were allocated to the xylitol group only if the parent/caregiver returned the informed consent form. School health nurses distributed xylitol candies to the students 3 times during the school day (after breakfast and lunch, and before leaving the school). Results: In the xylitol group, the baseline DS and DMFS scores were 3.4 and 8.2 and in the follow-up 1.9 and 7.1, respectively. In the control group, the baseline scores were DS 3.9 and DMFS 9.8, and the follow-up scores DS 3.9 and DMFS 13.2. Conclusion: Xylitol seemed to have a strong preventive and a clear remineralizing effect on caries.

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“…In view of the present topic, it may be more relevant to compare the effect of xylitol and fluorides when both have been used in the same study. Accordingly, the WHO field trials in Hungary [66,67] and French Polynesia [65] showed that substitution of xylitol for sugar in confectioneries resulted in more effective caries prevention than in fluoride-using control groups, the percentage differences amounting to 38-45 and 58-62, respectively, in favour of xylitol. The recent mother-child studies showed that maternal use of xylitol gum prevented caries in infants more effectively than topical fluoride varnish treatments [76] .…”

Section: Review Of Caries Trials: Effectiveness and Safety Of Xylitolmentioning

confidence: 99%

Sugar Alcohol Sweeteners as Alternatives to Sugar with Special Consideration of Xylitol

Mäkinen¹

2011

Med Princ Pract

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Introduction: Dental caries is a diet-associated disease which continues to be a serious health problem in most industrialized and developing countries. Strategies to maximize caries prevention should automatically consider the use of sugar substitutes. It is important that public health authorities are made cognizant of the availability of new polyol-type sugar substitutes. Review Summary: Clinical studies have shown that xylitol, a natural, physiologic sugar alcohol of the pentitol type, can be used as a safe and effective caries-limiting sweetener. Habitual use of xylitol-containing food and oral hygiene adjuvants has been shown to reduce the growth of dental plaque, to interfere with the growth of caries-associated bacteria, to decrease the incidence of dental caries, and to be associated with remineralization of caries lesions. Numerous public regulatory bodies have endorsed the use of xylitol as a caries-limiting agent. Other sugar alcohols that have been successfully used as sugar substitutes include D-glucitol (sorbitol), which, however, owing to its hexitol nature, normally has no strong effect on the mass and adhesiveness of bacterial plaque and on the growth of mutans streptococci. A tetritol-type alditol, erythritol, has shown potential as a non-cariogenic sugar substitute. Combinations of xylitol and erythritol may reduce the incidence of caries more effectively than either alditol alone. Conclusions: Partial sugar substitution with polyols is an important dietary tool in the prevention of dental caries that should be used to enhance existing fluoride-based caries prevention programmes. The most effective method of conveying this information to the public is through a proper health claim for these alditols in food labelling. The present review summarizes clinical and biochemical aspects of the above three dietary polyols and emphasizes the role of sugar substitution as a potential health-promoting strategy.

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Collaborative WHO xylitol field studies in Hungary I. Three-year caries activity in institutionalized children

Cited by 57 publications

References 19 publications

Collaborative WHO Xylitol Field Study in French Polynesia

Collaborative WHO Xylitol Field Study in French Polynesia

Field Trial on Caries Prevention with Xylitol Candies among Disabled School Students

Sugar Alcohol Sweeteners as Alternatives to Sugar with Special Consideration of Xylitol

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