Colistin-Loaded Polydopamine Nanospheres Uniformly Decorated with Silver Nanodots: A Nanohybrid Platform with Improved Antibacterial and Antibiofilm Performance

Ran, Huan-Huan; Cheng, Xiaotong; Gao, Ge; Sun, Wei; Jiang, Yao‐Wen; Zhang, Xiaodong; Jia, Hao‐Ran; Qiao, Ying; Wu, Fu‐Gen

doi:10.1021/acsabm.0c00163

Cited by 41 publications

(30 citation statements)

References 66 publications

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“…For example, lipid-based nanostructures encapsulating Col were proposed by several authors [ 21 , 22 , 23 , 24 , 25 ] and different chitosan-based nanocarriers have been shown to improve Col antimicrobial activity [ 26 , 27 ]. Moreover, recently Ran HH et al [ 28 ] developed Colistin-loaded polydopamine nanospheres decorated with silver nanodots with improved antimicrobial and antibiofilm activity. In this contest, protein-based polymers such as albumin have been considered as drug carriers due to their non-toxicity, biocompatibility, biodegradability and poor immunogenic properties [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Enhanced Antimicrobial and Antibiofilm Effect of New Colistin-Loaded Human Albumin Nanoparticles

et al. 2021

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Multidrug-resistant (MDR) Gram-negative bacteria (GNB), such as Acinetobacter and Klebsiella, are responsible for severe hospital-acquired infections. Colistin, despite its toxicity and low tissue penetration, is considered the last resort antibiotic against these microorganisms. Of concern, the use of Colistin has recently been compromised by the emergence of Colistin resistance. Herein, we developed a new formulation consisting of multifunctional chitosan-coated human albumin nanoparticles for the delivery of Colistin (Col/haNPs). Col/haNPs were in vitro characterized for encapsulation efficiency, drug release, stability and cytotoxicity and were evaluated for antibacterial activity against MDR GNB (Acinetobacter baumannii and Klebsiella pneumoniae). Col/haNPs showed sizes lower than 200 nm, high encapsulation efficiency (98.65%) and prolonged in vitro release of Colistin. The safety of the nanoformulation was demonstrated by a negligible cytotoxicity on human fibroblasts and hemolytic activity. Col/haNPs evidenced a high antibacterial effect with a significant decrease in MIC values compared to free Colistin, in particular against Col-resistant strains with a pronounced decline of bacterial growth over time. Moreover, Col/haNPs exhibited an inhibitory effect on biofilm formation that was 4 and 60 fold higher compared to free Colistin, respectively for Colistin susceptible and resistant A. baumannii. Our findings suggest that Col/haNPs could represent a promising Colistin nanocarrier with high antimicrobial activity on MDR GNB.

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Section: Discussionmentioning

confidence: 99%

Enhanced Antimicrobial and Antibiofilm Effect of New Colistin-Loaded Human Albumin Nanoparticles

et al. 2021

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“…It is widely recognized that the mechanism of employing hyperthermia for killing microorganisms is destroying diverse life-fundamental molecules or structures, including protein denaturation, lipid evaporation, and cell membrane breakage [ 2 , 52 ]. To date, many kinds of PTAs, such as carbon-based nanomaterials [ 53 , 54 ], noble metal nanomaterials [ 55 , 56 ], other metal-containing nanocomposites [ 57 ], and conjugated polymers [ 35 , 36 ], have been used for antimicrobial applications and have established their unique advantages. Moreover, owing to the uneven heat distribution in the bacterial biofilms, it is difficult to completely eradicate the bacteria within the biofilms via PTT alone.…”

Section: Applications Of Low-temperature Pttmentioning

confidence: 99%

Low-Temperature Photothermal Therapy: Strategies and Applications

Duan

2021

Research

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131

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Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal resistance, and thus, the efficacy of PTT may be dramatically decreased. In the meantime, the uncontrollable diffusion of heat can pose a threat to the surrounding healthy tissues. Recently, low-temperature PTT (also known as mild PTT or mild-temperature PTT) has demonstrated its remarkable capacity of conquering these obstacles and has shown excellent performance in bacterial elimination, wound healing, and cancer treatments. Herein, we summarize the recently proposed strategies for achieving low-temperature PTT based on nanomaterials and introduce the synthesis, characteristics, and applications of these nanoplatforms. Additionally, the combination of PTT and other therapeutic modalities for defeating cancers and the synergistic cancer therapeutic effect of the combined treatments are discussed. Finally, the current limitations and future directions are proposed for inspiring more researchers to make contributions to promoting low-temperature PTT toward more successful preclinical and clinical disease treatments.

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“…The synergistic actions of two or more antibacterial drugs as nanohybrids have been established to be effective in the treatment of refractory bacterial infections. The colistin-loaded PDA nanospheres decorated with silver nanodots are reported by Ran et al (2020) to exhibit powerful antibacterial and antibiofilm effects.…”

Section: Cationic Charge Enriched Pda-fabricated Surfaces: Effect On mentioning

confidence: 99%

Recent Advances in a Polydopamine-Mediated Antimicrobial Adhesion System

et al. 2021

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The drug resistance developed by bacteria during antibiotic treatment has been a call to action for researchers and scientists across the globe, as bacteria and fungi develop ever increasing resistance to current drugs. Innovative antimicrobial/antibacterial materials and coatings to combat such infections have become a priority, as many infections are caused by indwelling implants (e.g., catheters) as well as improving postsurgical function and outcomes. Pathogenic microorganisms that can exist either in planktonic form or as biofilms in water-carrying pipelines are one of the sources responsible for causing water-borne infections. To combat this, researchers have developed nanotextured surfaces with bactericidal properties mirroring the topographical features of some natural antibacterial materials. Protein-based adhesives, secreted by marine mussels, contain a catecholic amino acid, 3,4-dihydroxyphenylalanine (DOPA), which, in the presence of lysine amino acid, empowers with the ability to anchor them to various surfaces in both wet and saline habitats. Inspired by these features, a novel coating material derived from a catechol derivative, dopamine, known as polydopamine (PDA), has been designed and developed with the ability to adhere to almost all kinds of substrates. Looking at the immense potential of PDA, this review article offers an overview of the recent growth in the field of PDA and its derivatives, especially focusing the promising applications as antibacterial nanocoatings and discussing various antimicrobial mechanisms including reactive oxygen species-mediated antimicrobial properties.

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Colistin-Loaded Polydopamine Nanospheres Uniformly Decorated with Silver Nanodots: A Nanohybrid Platform with Improved Antibacterial and Antibiofilm Performance

Cited by 41 publications

References 66 publications

Enhanced Antimicrobial and Antibiofilm Effect of New Colistin-Loaded Human Albumin Nanoparticles

Enhanced Antimicrobial and Antibiofilm Effect of New Colistin-Loaded Human Albumin Nanoparticles

Low-Temperature Photothermal Therapy: Strategies and Applications

Recent Advances in a Polydopamine-Mediated Antimicrobial Adhesion System

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