Colchicine in dermatology: Rediscovering an old drug with novel uses

Sardana, Kabir; Sinha, Surabhi; Sachdeva, Sandeep

doi:10.4103/idoj.idoj_475_20

Cited by 13 publications

(30 citation statements)

References 48 publications

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“…However, it has been reported to be effective, especially in palmoplantar pustulosis and pustular psoriasis [ 75 ]. It inhibits the inflammasome of receptor protein 3 (NLRP3) of the nucleotide-binding domain, which then inhibits the production of IL-1, IL-6, and TNF-α [ 76 ].…”

Section: Anti-psoriatic Treatment and Its Influence On Atherosclerosismentioning

confidence: 99%

Killing Two Birds with One Stone: Potential Therapies Targeting Psoriasis and Atherosclerosis at the Same Time

Šabović

Zorko

Janić

2022

IJMS

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Psoriasis is a chronic systemic inflammatory disease. Due to systemic inflammation, it is associated with many comorbidities. Among them, cardiovascular diseases represent the most common causes of morbidity and mortality in this population. Therefore, physicians treating patients with psoriasis should keep in mind that, as important as the treatment of psoriasis, awareness of cardiovascular risk deserves additional attention. Thus, in parallel with psoriasis treatment, a cardiovascular risk assessment must also be performed and addressed accordingly. In addition to encouraging non-pharmacologic strategies for a healthy lifestyle, physicians should be familiar with different pharmacologic options that can target psoriasis and reduce cardiovascular risk. In the present article, we present the pathophysiological mechanisms of the psoriasis and cardiometabolic interplay, our view on the interaction of psoriasis and cardiovascular disease, review the atherosclerotic effect of therapeutic options used in psoriasis, and vice versa, i.e., what the effect of medications used in the prevention of atherosclerosis could be on psoriasis.

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Section: Anti-psoriatic Treatment and Its Influence On Atherosclerosismentioning

confidence: 99%

Killing Two Birds with One Stone: Potential Therapies Targeting Psoriasis and Atherosclerosis at the Same Time

Šabović

Zorko

Janić

2022

IJMS

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“…Monitoring for the adverse effects by regular complete blood counts, liver and renal function tests. The total daily dose should be ≤4 mg and in renal patients ≤2 mg.[ 29 ]…”

Section: Introductionmentioning

confidence: 99%

Updates on management of leprosy in the context of COVID-19 pandemic: Recommendations by IADVL SIG Leprosy

Bhardwaj

Gupta

Narang

et al. 2021

Indian Dermatol Online J

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The Special Interest Group (SIG) on leprosy thought it to be prudent to revisit its previous practice recommendations through this update. During this period, the pandemic course shifted to a 'second wave' riding on the 'delta variant'. While the number of cases increased manifold, so did the research on all aspects of the disease. Introduction of vaccination and data from various drug trials have an impact on current best practices on management of diseases including leprosy. The beneficial results of using steroids in management of COVID-19, gives elbow room regarding its usage in conditions like lepra reactions. On the other hand, the increase in cases of Mucormycosis again underlines applying due caution while recommending immunosuppressants to a patient already suffering from COVID-19. This recommendation update from SIG leprosy reflects current understanding about managing leprosy while the dynamic pandemic continues with its ebbs and flows.

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“…The possible mechanisms of action of colchicine have been well elucidated by Gil et al [ 1 ] It includes downregulation of multiple inflammatory pathways, inhibition of microtubule formation, antifibrotic properties via inhibition of fibronectin and transforming growth factor-β1, and interference with leukocyte migration, adhesion, and degranulation. [ 4 5 ] It is a useful drug in the therapeutic armamentarium for many neutrophilic dermatoses. [ 4 ] Also, low dose colchicine has been found to be efficacious in treating pyoderma gangrenosum.…”

mentioning

confidence: 99%

“…[ 4 5 ] It is a useful drug in the therapeutic armamentarium for many neutrophilic dermatoses. [ 4 ] Also, low dose colchicine has been found to be efficacious in treating pyoderma gangrenosum. [ 6 ] However, it should be kept in mind that the most common side effects which include nausea, vomiting, and diarrhea can be severe at times, even at recommended doses leading to drug discontinuation.…”

mentioning

confidence: 99%

“…[ 6 ] However, it should be kept in mind that the most common side effects which include nausea, vomiting, and diarrhea can be severe at times, even at recommended doses leading to drug discontinuation. [ 4 ] In addition to this, the uncommon side effects can be quite serious and life threatening at times like arrhythmias and bone marrow suppression, hence it may not be recommended as first-line therapy in all cases.…”

mentioning

confidence: 99%

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