Colchicine improves the alterations in the liver adenylate cyclase system of cirrhotic rats

PREVENTION OF CCL4‐INDUCED LIVER CIRRHOSIS BY SILYMARIN

“…Metabolic alterations related to liver fibrogenesis are complex and include modifications in the levels of cyclic adenosine monophosphate (CAMP) that may regulate the amount of collagen degraded intracellularly in some systems (Rojkind and Kershenobich, 1983). Since our previous findings indicated that CCl, liver cirrhosis is characterized by increases in adenylate cyclase activity and CAMP levels (Mourelle et al, 1981), it could be suggested that amelioration of fibrosis by silymarin is mediated by the agent's plasma membrane effects (i.e., the adenylate cyclase system). Nevertheless, the improvement in fibrosis and in liver cell functions may be due to distinct processes that could occur through independent pharmacological activities of the drug or its metabolites.…”

“…The ratio of CCl, to oil was increased weekly as described previously (Mourelle et al, 1981). Liver cirrhosis was produced by IP administration of 0.15 rnl of CCl, in mineral oil, 3 times a week for 8 wk.…”

“…Liver cirrhosis was produced by IP administration of 0.15 rnl of CCl, in mineral oil, 3 times a week for 8 wk. The ratio of CCl, to oil was increased weekly as described previously (Mourelle et al, 1981). Four groups of 10 animals each were used.…”

PREVENTION OF CCL4‐INDUCED LIVER CIRRHOSIS BY SILYMARIN

“…Metabolic alterations related to liver fibrogenesis are complex and include modifications in the levels of cyclic adenosine monophosphate (CAMP) that may regulate the amount of collagen degraded intracellularly in some systems (Rojkind and Kershenobich, 1983). Since our previous findings indicated that CCl, liver cirrhosis is characterized by increases in adenylate cyclase activity and CAMP levels (Mourelle et al, 1981), it could be suggested that amelioration of fibrosis by silymarin is mediated by the agent's plasma membrane effects (i.e., the adenylate cyclase system). Nevertheless, the improvement in fibrosis and in liver cell functions may be due to distinct processes that could occur through independent pharmacological activities of the drug or its metabolites.…”

“…The ratio of CCl, to oil was increased weekly as described previously (Mourelle et al, 1981). Liver cirrhosis was produced by IP administration of 0.15 rnl of CCl, in mineral oil, 3 times a week for 8 wk.…”

“…Liver cirrhosis was produced by IP administration of 0.15 rnl of CCl, in mineral oil, 3 times a week for 8 wk. The ratio of CCl, to oil was increased weekly as described previously (Mourelle et al, 1981). Four groups of 10 animals each were used.…”

Untitled

“…Also, colchicine, a recognized liver protector which prevents the assembly of cytoplasmatic microtubules, inhibits the transcellular movement of collagen 20,21 , stimulates the production of collagenase in cultures of synovial tissue 22 and exerts a stabilizing effect on the plasma membranes of the hepatocyte 23 . It prevents infiltration reverses CC1 4 -induced liver cirrhosis in rats 24,25 .…”

Erythrocyte membrane Na,K ATP ase activity can be a marker of liver histopathology

“…Ege University School of Medicine Department of Biochemistry Bornova 35100 Izmir-TURKEY membrane lipid composition and fluidity (1,2,3,4,9,10). In humans acute hepatitis C results in chronic elevations of serum transaminase levels following nearly one half of cases.…”

PREVENTION OF CCL4‐INDUCED LIVER CIRRHOSIS BY SILYMARIN

“…Metabolic alterations related to liver fibrogenesis are complex and include modifications in the levels of cyclic adenosine monophosphate (CAMP) that may regulate the amount of collagen degraded intracellularly in some systems (Rojkind and Kershenobich, 1983). Since our previous findings indicated that CCl, liver cirrhosis is characterized by increases in adenylate cyclase activity and CAMP levels (Mourelle et al, 1981), it could be suggested that amelioration of fibrosis by silymarin is mediated by the agent's plasma membrane effects (i.e., the adenylate cyclase system). Nevertheless, the improvement in fibrosis and in liver cell functions may be due to distinct processes that could occur through independent pharmacological activities of the drug or its metabolites.…”

“…The ratio of CCl, to oil was increased weekly as described previously (Mourelle et al, 1981). Liver cirrhosis was produced by IP administration of 0.15 rnl of CCl, in mineral oil, 3 times a week for 8 wk.…”

“…Liver cirrhosis was produced by IP administration of 0.15 rnl of CCl, in mineral oil, 3 times a week for 8 wk. The ratio of CCl, to oil was increased weekly as described previously (Mourelle et al, 1981). Four groups of 10 animals each were used.…”

Untitled

“…Also, colchicine, a recognized liver protector which prevents the assembly of cytoplasmatic microtubules, inhibits the transcellular movement of collagen 20,21 , stimulates the production of collagenase in cultures of synovial tissue 22 and exerts a stabilizing effect on the plasma membranes of the hepatocyte 23 . It prevents infiltration reverses CC1 4 -induced liver cirrhosis in rats 24,25 .…”

Erythrocyte membrane Na,K ATP ase activity can be a marker of liver histopathology

“…Ege University School of Medicine Department of Biochemistry Bornova 35100 Izmir-TURKEY membrane lipid composition and fluidity (1,2,3,4,9,10). In humans acute hepatitis C results in chronic elevations of serum transaminase levels following nearly one half of cases.…”

PREVENTION OF CCL4‐INDUCED LIVER CIRRHOSIS BY SILYMARIN

“…Metabolic alterations related to liver fibrogenesis are complex and include modifications in the levels of cyclic adenosine monophosphate (CAMP) that may regulate the amount of collagen degraded intracellularly in some systems (Rojkind and Kershenobich, 1983). Since our previous findings indicated that CCl, liver cirrhosis is characterized by increases in adenylate cyclase activity and CAMP levels (Mourelle et al, 1981), it could be suggested that amelioration of fibrosis by silymarin is mediated by the agent's plasma membrane effects (i.e., the adenylate cyclase system). Nevertheless, the improvement in fibrosis and in liver cell functions may be due to distinct processes that could occur through independent pharmacological activities of the drug or its metabolites.…”

“…The ratio of CCl, to oil was increased weekly as described previously (Mourelle et al, 1981). Liver cirrhosis was produced by IP administration of 0.15 rnl of CCl, in mineral oil, 3 times a week for 8 wk.…”

“…Liver cirrhosis was produced by IP administration of 0.15 rnl of CCl, in mineral oil, 3 times a week for 8 wk. The ratio of CCl, to oil was increased weekly as described previously (Mourelle et al, 1981). Four groups of 10 animals each were used.…”

Untitled

“…Also, colchicine, a recognized liver protector which prevents the assembly of cytoplasmatic microtubules, inhibits the transcellular movement of collagen 20,21 , stimulates the production of collagenase in cultures of synovial tissue 22 and exerts a stabilizing effect on the plasma membranes of the hepatocyte 23 . It prevents infiltration reverses CC1 4 -induced liver cirrhosis in rats 24,25 .…”

Erythrocyte membrane Na,K ATP ase activity can be a marker of liver histopathology

“…Ege University School of Medicine Department of Biochemistry Bornova 35100 Izmir-TURKEY membrane lipid composition and fluidity (1,2,3,4,9,10). In humans acute hepatitis C results in chronic elevations of serum transaminase levels following nearly one half of cases.…”