Colchicine for acute gout

Efficacy and safety of colchicine for the treatment of osteoarthritis: a systematic review and meta-analysis of intervention trials

“…Colchicine has a long history of use to treat acute flares in gout and is generally regarded as having a good safety profile, especially in low doses [47,48]. A recent systematic review showed that the common adverse events with colchicine use are limited to diarrhea and gastrointestinal events and SAEs, including the liver and hematological changes, muscle toxicity, and neuropathy, are rare in clinical trials [49].…”

Efficacy and safety of colchicine for the treatment of osteoarthritis: a systematic review and meta-analysis of intervention trials

“…Colchicine has a long history of use to treat acute flares in gout and is generally regarded as having a good safety profile, especially in low doses [47,48]. A recent systematic review showed that the common adverse events with colchicine use are limited to diarrhea and gastrointestinal events and SAEs, including the liver and hematological changes, muscle toxicity, and neuropathy, are rare in clinical trials [49].…”

Systematic analysis of inflammation and pain pathways in a mouse model of gout

“…However, accumulating clinical data suggested that benefits of these drugs were limited for gout patients and statistically significantly greater number of adverse events were reported for long term and/or high-dose usages. 47 , 48 Management and outcomes in people with chronic gout are poor. Novel treatments with high efficacy and minimal side effects are urgently needed for gout patients.…”

Effect of Baihu and Guizhi decoction in acute gouty arthritis: study protocol for a randomized controlled trial

“…It is a classic and specific drug for AGA that can attenuate inflammation and relieve pain. Many studies [ 17 – 19 ] have confirmed that low-dose and high-dose colchicine can effectively reduce the pain of a gout attack, and the side effects of low-dose colchicine are better than those of high-dose colchicine. Therefore, in recent years, several worldwide gout guidelines [ 20 , 21 ] have recommended low-dose colchicine or its combination with NSAIDs as a treatment for AGA.…”

Efficacy and safety of colchicine for the treatment of osteoarthritis: a systematic review and meta-analysis of intervention trials

“…Colchicine has a long history of use to treat acute flares in gout and is generally regarded as having a good safety profile, especially in low doses [47,48]. A recent systematic review showed that the common adverse events with colchicine use are limited to diarrhea and gastrointestinal events and SAEs, including the liver and hematological changes, muscle toxicity, and neuropathy, are rare in clinical trials [49].…”

Systematic analysis of inflammation and pain pathways in a mouse model of gout

“…However, accumulating clinical data suggested that benefits of these drugs were limited for gout patients and statistically significantly greater number of adverse events were reported for long term and/or high-dose usages. 47 , 48 Management and outcomes in people with chronic gout are poor. Novel treatments with high efficacy and minimal side effects are urgently needed for gout patients.…”

Effect of Baihu and Guizhi decoction in acute gouty arthritis: study protocol for a randomized controlled trial

“…It is a classic and specific drug for AGA that can attenuate inflammation and relieve pain. Many studies [ 17 – 19 ] have confirmed that low-dose and high-dose colchicine can effectively reduce the pain of a gout attack, and the side effects of low-dose colchicine are better than those of high-dose colchicine. Therefore, in recent years, several worldwide gout guidelines [ 20 , 21 ] have recommended low-dose colchicine or its combination with NSAIDs as a treatment for AGA.…”

Efficacy and safety of colchicine for the treatment of osteoarthritis: a systematic review and meta-analysis of intervention trials

“…Colchicine has a long history of use to treat acute flares in gout and is generally regarded as having a good safety profile, especially in low doses [47,48]. A recent systematic review showed that the common adverse events with colchicine use are limited to diarrhea and gastrointestinal events and SAEs, including the liver and hematological changes, muscle toxicity, and neuropathy, are rare in clinical trials [49].…”

Systematic analysis of inflammation and pain pathways in a mouse model of gout

“…However, accumulating clinical data suggested that benefits of these drugs were limited for gout patients and statistically significantly greater number of adverse events were reported for long term and/or high-dose usages. 47 , 48 Management and outcomes in people with chronic gout are poor. Novel treatments with high efficacy and minimal side effects are urgently needed for gout patients.…”

Effect of Baihu and Guizhi decoction in acute gouty arthritis: study protocol for a randomized controlled trial

“…It is a classic and specific drug for AGA that can attenuate inflammation and relieve pain. Many studies [ 17 – 19 ] have confirmed that low-dose and high-dose colchicine can effectively reduce the pain of a gout attack, and the side effects of low-dose colchicine are better than those of high-dose colchicine. Therefore, in recent years, several worldwide gout guidelines [ 20 , 21 ] have recommended low-dose colchicine or its combination with NSAIDs as a treatment for AGA.…”