COL6A3 polymorphisms were associated with lung cancer risk in a Chinese population

Abstract

Background: Lung cancer is one of the leading cause of cancer-related death in the world. Recently, many clinical researches have reported that COL6A3 had strong role in many diseases. The aim of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) in COL6A3 and lung cancer susceptibility. Method: Eight variants in COL6A3 were genotyped in a Chinese Han population including 510 cases and 495 controls using Agena MassARRAY. Genetic models and haplotype analyses were used to calculate the association between COL6A3 SNPs and lung cancer risk. And we assessed the relative risk by the odds ratio (OR) and 95% confidence interval (CI).Results: In our results, we observed that rs115510139 was linked to an increased risk of lung cancer in the codominant (adjusted OR = 1.61, 95%CI: 1.14-2.27, p = 0.007), dominant (adjusted OR = 1.36, 95%CI: 1.02-1.83, p = 0.037), recessive (adjusted OR = 1.41, 95%CI: 1.07-1.85, p = 0.015), and log-additive (adjusted OR = 1.27, 95%CI: 1.07-1.51, p = 0.006) models. After gender stratification analysis, we found that rs115510139, rs3736341 and rs12052971 were significant in males but were non-significant in females. Rs115510139 also can increase the risk of lung cancer in the population of age less than 61 years. When analyzed for the association with lung squamous carcinoma, rs13032404, rs115510139 and rs3736341 were related to the risk of lung cancer. Conclusions: Our findings indicated potential associations between COL6A3 polymorphisms and lung cancer risk, which may contribute to the identification of lung cancer patients in a Chinese population.

Prmt7 Downregulation in Mouse Spermatogonia Functions through miR-877-3p/Col6a3

“…The results showed Col6a3 expression was increased with Prmt7 downregulation, suggesting that Prmt7 downregulation in mouse spermatogonia might function through miR-877-3p/ Col6a3 . It has only been reported that Col6a3 is associated with cancer [ 53 , 54 ], muscular dystrophy [ 55 , 56 ], and obesity [ 57 , 58 ], which exhibits the possible similar roles of Prmt7 . However, thus far, there is no evidence showing the role of mmu-miR-877-3p or Col6a3 in male reproduction.…”

Identification of Key Prognostic Biomarker and Its Correlation with Immune Infiltrates in Pancreatic Ductal Adenocarcinoma

“…COL6A3 is an extracellular matrix protein that is typically found in most connective tissues, including muscle, skin, tendon, and vessels. Many recent studies have demonstrated the important role of COL6A3 in the diagnosis and prognosis of colorectal, lung, and prostate cancer [ 32 , 33 ]. A high level of expression of COL6A3 has been observed in pancreatic tumors, where it was correlated with negative prognostic factors [ 34 ].…”

Methylome-wide analysis reveals epigenetic marks associated with resistance to tuberculosis in HIV-infected individuals from East Africa

“…Collagen VI-related myopathies are associated with decreased pulmonary function [22]. COL6A3 has been associated with lung cancer [23]. Thus, we hypothesize that COL6A3 may influence TB susceptibility through its effect on lung function.…”