Coinfection in SARS-CoV-2 Infected Children Patients

Abstract

Introduction: The aim of this study is to determine the coinfections with other respiratory pathogens in SARS-CoV-2 infected children patients in a pediatric unit in Istanbul.
 Methodology: This retrospective descriptive study was conducted in a 1000-bedded tertiary education and research hospital in Istanbul. All children hospitalized with the diagnosis of SARS-CoV-2 infection had been investigated for respiratory agents in nasopharyngeal secretions. Laboratory confirmation of SARS-CoV-2 and the other respiratory pathogens were performed using reverse transcriptase-polymerase chain reaction (RT-PCR).
 Results: A total of 209 hospitalized children with suspected SARS-CoV-2 infection between March 2020-May 2020 were enrolled in this study. Among 209 children, 93 (44.5%) were RT-PCR positive for SARS-CoV-2 infection, and 116 (55.5%) were RT-PCR negative. The most common clinical symptoms in all children with SARS-CoV-2 infection were fever (68.8%) and cough (57.0%). The other clinical symptoms in decreasing rates were headache (10.8%), myalgia (5.4%), sore throat (3.2%), shortness of breath (3.2%), diarrhea (2.2%) and abdominal pain in one child. In 7 (7.5%) patients with SARS-CoV-2 infection, coinfection was detected. Two were with rhinovirus/enterovirus, two were with Coronavirus NL63, one was with adenovirus, and one was with Mycoplasma pneumoniae. In one patient, two additional respiratory agents (rhinovirus/enterovirus and adenovirus) were detected. There was a significantly longer hospital stay in patients with coinfection (p = 0.028).
 Conclusions: Although the coinfection rate was low in SARS-CoV-2 infected patients in our study, we found coinfection as a risk factor for length of hospital stay in the coinfected patient group.

Factores de riesgo vinculados a infecciones en espacios operatorios

“…Mientras que (Karaaslan et al 2021), establecen que la coinfección es un factor de riesgo para la duración de la estancia hospitalaria, por cuanto en pacientes con infección por Reconocidos colegas de este mismo centro hospitalario, han publicado que las infecciones respiratorias y cardiovasculares fueron las más frecuentes en su casuística de 2013, en consonancia con los resultados anteriores. Como puede advertirse, aunque la infección del sitio operatorio prevalece en el paciente operado, no es despreciable la a elevar aún más el riesgo de morbilidad y mortalidad posoperatorias, sobre todo la que afecta a los aparatos respiratorio, cardiovascular y urinario.…”

SARS-CoV-2: The Impact of Co-Infections with Particular Reference to Mycoplasma pneumonia—A Clinical Review

“…Two additional respiratory agents (rhinovirus/enterovirus and adenovirus) were also found in one patient. The authors maintain that co-infected patients are shown to be at a higher risk factor of hospitalization compared with patients exclusively affected by SARS-CoV-2 [ 23 ].…”

Distribution of Viral Respiratory Infections during the COVID-19 Pandemic Using the FilmArray Respiratory Panel

“…The authors indicated that the possibility of treatable organisms should be ruled out even in the case of a very rare coinfection, such as COVID-19 and adenovirus. In addition, Karaaslan A et al found coinfections with other respiratory organisms in SARS-CoV-2-infected pediatric patients [ 43 ]. The authors identified a SARS-CoV-2-infected child who had two respiratory pathogens—rhinovirus/enterovirus and adenovirus—and the coinfection led to a considerably longer hospital stay.…”