1993
DOI: 10.1021/bi00091a010
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Abstract: Previous work has demonstrated that the cellular response to ionizing radiation includes transcriptional activation of the c-jun early response gene. The present studies demonstrate that this induction of c-jun expression is temporally related to the appearance of internucleosomal DNA fragmentation. These events were maximal at 6 h and transient after exposure to lethal doses (20 Gy) of ionizing radiation. We also demonstrate that N-acetyl-L-cysteine (NAC), an antioxidant, inhibits X-ray-induced c-jun expressi… Show more

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Cited by 66 publications
(19 citation statements)
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References 44 publications
(52 reference statements)
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“…Compared with native chromatin, apoptotic oligonucleosomal fragments contained less histone H1 (Borisova et al, 1984;Bell et al, 1990). Interestingly, a rapid increase in poly(ADPribose) polymerase (PARP) activity was observed upon induction of apoptosis by radiation, followed by the poly(ADP-ribosyl)ation of histone H1 (Manome et al, 1993). Inhibition of PARP activity by nicotinamide or similar compounds inhibited DNA fragmentation.…”
Section: Does Mitochondrial Dna Damage Play a Role In Cell Death?mentioning
confidence: 99%
“…Compared with native chromatin, apoptotic oligonucleosomal fragments contained less histone H1 (Borisova et al, 1984;Bell et al, 1990). Interestingly, a rapid increase in poly(ADPribose) polymerase (PARP) activity was observed upon induction of apoptosis by radiation, followed by the poly(ADP-ribosyl)ation of histone H1 (Manome et al, 1993). Inhibition of PARP activity by nicotinamide or similar compounds inhibited DNA fragmentation.…”
Section: Does Mitochondrial Dna Damage Play a Role In Cell Death?mentioning
confidence: 99%
“…The promoter region of cyclin D1 gene contains binding sites for redox-sensitive transcription factors including cyclic adenosine monophosphate response element-binding protein, nuclear factor-kB (NF-kB), activator protein 1 and Sp1. Several reports show redox modifications of critical cysteines in these transcription factors regulate their DNA-binding activities (Abate et al, 1990;Toledano and Leonard, 1991;Manome et al, 1993;Ohba et al, 1994;Janssen et al, 1995;Lo and Cruz, 1995). Hence, redox-state-dependent modulation of the activity of these transcription factors could significantly influence cyclin D1 transcription.…”
Section: Intracellular Redox State and Cell Cycle Proteinsmentioning
confidence: 99%
“…c-Jun: pro-apoptotic gene c-jun expression is induced in response to treatments which frequently triggers apoptosis, among them UV, ionizing radiation, hydrogen peroxide and Tumour Necrosis Factor a (TNFa) (Brenner et al, 1989;Devary et al, 1991;Manome et al, 1993). c-jun and c-fos expression is also upregulated in lymphocytes that undergo apoptosis in response to IL6 depletion and c-jun or c-fos antisense oligonucleotides protect these cells from death response (Colotta et al, 1992;Preston et al, 1996).…”
Section: Apoptosis and Senescencementioning
confidence: 99%