Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers

Ho, Peh Joo; Yeoh, Yen Shing; Miao, Hui; Lim, Swee Ho; Tan, Ern Yu; Tan, Benita Kiat Tee; Tan, Veronique Kiak Mien; Tan, Su Ming; Yong, Wei Sean; Wong, Fuh Yong; Madhukumar, Preetha; Chan, Ching Wan; Iau, Philip Tsau Choong; Lee, Soo‐Chin; Putti, Thomas Choudary; Lee, Jin Yee; Lim, Geok Hoon; Woo, Evan; Yan, Zhiyan; Chan, Peter; Chen, Juliana Jia Chuan; Lu, Sarah; Dent, Rebecca; Lee, Wai Peng; Mok, Chi Wei; Seah, Jaime Chin Mui; Sim, Xueling; Dam, Rob M van; Chia, Kee Seng; Li, Jingmei; Hartman, Mikael

doi:10.1371/journal.pone.0250102

Cited by 14 publications

(22 citation statements)

References 23 publications

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“…The Singapore Breast Cancer Cohort (SGBCC) is a multicenter cohort study of breast cancer patients in Singapore. Established in 2010, it was established with the purpose of investigating the associations between various genetic and non-genetic factors and breast cancer risk (cohort profile described in [ 14 ]). Patients were recruited across six recruitment sites, between 2010 to 2016, namely: National University Hospital (NUH, Singapore, Singapore), KK Women’s and Children’s Hospital (KKH, Singapore, Singapore), Tan Tock Seng Hospital (TTSH, Singapore, Singapore), National Cancer Centre Singapore (NCCS, Singapore, Singapore), Singapore General Hospital (SGH, Singapore, Singapore), and Changi General Hospital (CGH, Singapore, Singapore).…”

Section: Methodsmentioning

confidence: 99%

“…Patients were recruited across six recruitment sites, between 2010 to 2016, namely: National University Hospital (NUH, Singapore, Singapore), KK Women’s and Children’s Hospital (KKH, Singapore, Singapore), Tan Tock Seng Hospital (TTSH, Singapore, Singapore), National Cancer Centre Singapore (NCCS, Singapore, Singapore), Singapore General Hospital (SGH, Singapore, Singapore), and Changi General Hospital (CGH, Singapore, Singapore). The recruiting hospitals collectively treat ~76% of the breast cancer patients in Singapore [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

“…Information on vital status and cause of death were obtained via a linkage with the Registry of Births and Deaths [ 14 ], using each individual’s unique National Registration Identity Card (NRIC) number. Hospitals had differing schedules in updating their in-house breast cancer registry; in turn, the collection of variables ended at different points (NUH: 30 April 2017; KKH: 30 June 2017; CGH: 16 April 2018; TTSH: 30 April 2018).…”

Section: Methodsmentioning

confidence: 99%

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Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival

Lim

et al. 2022

Cancers

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Physical activity (PA) is known to reduce breast cancer (BC) risk and improve patient prognosis. However, the association between pre-diagnostic PA and the aggressiveness of BC is unclear. We investigated the associations between PA, BC tumour characteristics, and survival. This retrospective observational study included 7688 BC patients from the Singapore Breast Cancer Cohort (2010–2016). PA information from the questionnaire included intensity (light/moderate/vigorous) and duration (<1 h/1–2 h/>2 h per week). A PA score (1–5) incorporating intensity and duration was calculated. Associations between PA score and tumour characteristics such as stage, histological grade, nodal and hormone receptor status were examined using multinomial regression. Moreover, 10-year overall survival was estimated using Cox regression analysis in 6572 patients after excluding patients with invalid survival data and stage IV disease. Breast tumours associated with higher PA score were more likely to be non-invasive (ORinvasive vs. non-invasive(reference) [95% CI]: 0.71 [0.58–0.87], p-trend = 0.001), of lower grade (ORpoorly vs. well differentiated(reference): 0.69 [0.52–0.93], p = 0.014), ER-positive (ORER-negative vs. ER-positive(reference): 0.94 [0.89–1.00], p-trend = 0.049), PR-positive (ORPR-negative vs. PR-positive(reference): 0.82 [0.67–0.99], p = 0.041), HER2-negative (ORHER2-negative vs. HER2-positive(reference): 1.29 [1.02–1.62], p-trend = 0.002), and less likely to be of HER2-overexpressed subtype (ORHER2-overexpressed vs. Luminal A(reference): 0.89 [0.81–0.98], p-trend = 0.018). These associations (odds ratios) were more pronounced among post-menopausal patients. A higher PA score did not improve survival. Higher levels of pre-diagnostic PA were associated with less aggressive tumours in BC patients. This illustrated another benefit of PA in addition to its known role in BC risk reduction.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival

Lim

et al. 2022

Cancers

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“…The Singapore Breast Cancer Cohort (SGBCC) study includes women aged 21 years and above diagnosed with either breast carcinoma in situ or invasive breast cancer at one of the six participating restructured hospitals in Singapore (National University Hospital, KK Women’s and Children’s Hospital, Tan Tock Seng Hospital, Singapore General Hospital, National Cancer Centre Singapore, Changi General Hospital). These six hospitals collectively diagnose and treat ~76% of all breast cancer cases in Singapore [ 8 ]. Patients were a mixture of prevalent and incident cases from the three main ethnic groups, Chinese (81%), Malay (13%), and Indian (6%).…”

Section: Methodsmentioning

confidence: 99%

“…Data from each study were previously described (SGBCC [ 8 ], MyBrCa [ 9 ], and KOHBRA [ 10 ]). The genetic and clinical data used in this study were obtained via a data request (concept #680) to the Breast Cancer Association Consortium (BCAC).…”

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confidence: 99%

Germline breast cancer susceptibility genes, tumor characteristics, and survival

Khng

Loh

et al. 2021

Genome Med

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Background Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility genes on tumor characteristics and survival in 8852 breast cancer patients of Asian descent. Methods Gene panel sequencing was performed for 34 known or suspected breast cancer predisposition genes, of which nine genes (ATM, BRCA1, BRCA2, CHEK2, PALB2, BARD1, RAD51C, RAD51D, and TP53) were associated with breast cancer risk. Associations between PTV carriership in one or more genes and tumor characteristics were examined using multinomial logistic regression. Ten-year overall survival was estimated using Cox regression models in 6477 breast cancer patients after excluding older patients (≥75years) and stage 0 and IV disease. Results PTV9genes carriership (n = 690) was significantly associated (p < 0.001) with more aggressive tumor characteristics including high grade (poorly vs well-differentiated, odds ratio [95% confidence interval] 3.48 [2.35–5.17], moderately vs well-differentiated 2.33 [1.56–3.49]), as well as luminal B [HER−] and triple-negative subtypes (vs luminal A 2.15 [1.58–2.92] and 2.85 [2.17–3.73], respectively), adjusted for age at diagnosis, study, and ethnicity. Associations with grade and luminal B [HER2−] subtype remained significant after excluding BRCA1/2 carriers. PTV25genes carriership (n = 289, excluding carriers of the nine genes associated with breast cancer) was not associated with tumor characteristics. However, PTV25genes carriership, but not PTV9genes carriership, was suggested to be associated with worse 10-year overall survival (hazard ratio [CI] 1.63 [1.16–2.28]). Conclusions PTV9genes carriership is associated with more aggressive tumors. Variants in other genes might be associated with the survival of breast cancer patients. The finding that PTV carriership is not just associated with higher breast cancer risk, but also more severe and fatal forms of the disease, suggests that genetic testing has the potential to provide additional health information and help healthy individuals make screening decisions.

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Evaluation of SNPs associated with mammographic density in European women with mammographic density in Asian women from South-East Asia

Mariapun

Eriksson

et al. 2023

Breast Cancer Res Treat

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Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers

Cited by 14 publications

References 23 publications

Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival

Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival

Germline breast cancer susceptibility genes, tumor characteristics, and survival

Evaluation of SNPs associated with mammographic density in European women with mammographic density in Asian women from South-East Asia

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