Cohort Profile: The Danish nurse cohort

Hundrup, Yrsa Andersen; Simonsen, Mette Kildevæld; Jørgensen, Torben; Obel, Erik B.

doi:10.1093/ije/dyr042

Cited by 94 publications

(96 citation statements)

References 26 publications

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“…The Danish Nurse Cohort was inspired by the US Nurse Health Study and was designed to investigate the health effects of hormone replacement therapy (HRT) in an European population 19. The cohort was initiated in 1993 by sending a questionnaire to 23 170 female Danish nurses (44 years and older), members of the Danish Nursing Organization, which includes 95% of all nurses in Denmark, both retired and working nurses.…”

Section: Methodsmentioning

confidence: 99%

Night shift work and incidence of diabetes in the Danish Nurse Cohort

et al. 2016

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Section: Methodsmentioning

confidence: 99%

Night shift work and incidence of diabetes in the Danish Nurse Cohort

et al. 2016

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“…The Danish Nurse Cohort, which has previously been described in detail [17], was established in 1993, and invited all female Danish nurses above 44 years of age, who were members of the Danish Nurses' Association (N ¼ 23 170) to participate in the study [17]. Information on health, socioeconomic status, working conditions, and lifestyle factors were collected by questionnaire at baseline in 1993, with followup in 1999 and 2009.…”

Section: Study Populationmentioning

confidence: 99%

Prolonged job strain and subsequent risk of cancer in women – a longitudinal study, based on the Danish Nurse Cohort

et al. 2017

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Background: The role of psychological stress in cancer risk is continuously debated. Stress at work is the most common form of stress and previous studies have shown inconsistent results regarding cancer risk. In this longitudinal study, we examined the association between prolonged job strain across six years and subsequent cancer risk. Methods and materials: We used data from 6571 cancer-free women from the Danish Nurse Cohort aged 45-70 years at inclusion, and self-reported questionnaires on job strain at baseline in 1993 and again in 1999. Prolonged job strain was defined as high job busyness and speed, and low control in both 1993 and 1999. Information on cancer diagnosis was obtained from the Danish Cancer Registry. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals for overall cancer as well as subgroups of virus immune-related, hormone-related, digestive and lung cancers according to level of prolonged job strain. The women were followed from 1 January 2000 until cancer diagnosis, emigration, death or 31 December 2013 (mean follow-up 13 years) and models were adjusted for potential confounders. Effect modification was examined according to working nightshifts and full time. Results: No significant differences in the risk of overall cancer or any of the cancer subgroups were identified in relation to prolonged busyness, speed, influence, or overall job strain. Effect modification by working full time was observed when examining job influence in relation to overall cancer risk, and by working nightshifts when examining job influence in relation to hormone related cancer risk. However, none of the associations were significant in stratified analyses. Conclusion: We found no evidence of an increased risk of any cancer among women with prolonged job strain. Since a large proportion of cancer patients perceive psychological stress as a possible cause of their cancer disease, it is of importance to communicate these findings to the public.

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“…In 1999, a second questionnaire was posted to the same nurses and also to nurses who had attained 45 years of age since the first questionnaire in 1993. A total of 15 322 nurses (76%) completed the second questionnaire [12]. Nurses with a diagnosis of cancer at baseline (N ¼ 1096) and nurses for whom information on SRH in 1993 and/or in 1999 (N ¼ 583) was missing were excluded from this study (Figure 1).…”

Section: Study Population and Data Materialsmentioning

confidence: 99%

Self-rated health and cancer risk – a prospective cohort study among Danish women

2016

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Background: Self-rated health (SRH) has been shown to be a strong predictor of mortality from a number of major chronic diseases, however, the association with cancer remains unclear. The aim of this study was to investigate a possible association between change in SRH and cancer incidence. Materials and methods: SRH and information on lifestyle and other risk factors were obtained for 13-636 women in the Danish Nurse Cohort. Cancers that developed during 12 years of follow-up were identified in the National Patient Registry. An association between SRH and cancer was examined in a Cox proportional hazards model with adjustment for age, smoking, alcohol, marital status, physical activity, body mass index and estrogen replacement therapy. Results: No significant association was found between SRH and overall cancer incidence in the ageadjusted Cox proportional hazards model (1.04; 95% CI 0.93-1.16), even after adjustment for potential confounding factors (HR 1.08; 95% CI 0.96-1.21). Likewise, there was no significant association between SRH and breast cancer (HR 1.09; 95% CI 0.89-1.33), lung cancer (HR 1.03; 95% CI 0.71-1.49) or colon cancer (HR 1.08; 95% CI 0.75-1.54). Conclusion: SRH is not significantly associated with the incidence of all cancers or breast, lung or colon cancer among Danish female nurses. Women who reported a decrease in SRH between 1993 and 1999 had the same risk for cancer as those who reported unchanged or improved SRH.

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Cohort Profile: The Danish nurse cohort

Cited by 94 publications

References 26 publications

Night shift work and incidence of diabetes in the Danish Nurse Cohort

Night shift work and incidence of diabetes in the Danish Nurse Cohort

Prolonged job strain and subsequent risk of cancer in women – a longitudinal study, based on the Danish Nurse Cohort

Self-rated health and cancer risk – a prospective cohort study among Danish women

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