Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort

Fraser, Abigail; Macdonald‐Wallis, Corrie; Tilling, Kate; Boyd, Andy; Golding, Jean; Smith, George Davey; Henderson, John; Macleod, John; Molloy, Lynn; Ness, Andy R; Ring, Susan M.; Nelson, Scott M.; Lawlor, Debbie A.

doi:10.1093/ije/dys066

Cited by 2,146 publications

(2,224 citation statements)

References 69 publications

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“…All participants gave written informed consent. Full details of the study, measures and sample can be accessed elsewhere (Boyd et al., 2013; Fraser et al., 2013). Please note that the study website contains details of all the data that is available through a fully searchable data dictionary (http://www.bris.ac.uk/alspac/researchers/data-access/data-dictionary).…”

Section: Methodsmentioning

confidence: 99%

Investigating late‐onset ADHD: a population cohort investigation

Cooper

Hammerton

Collishaw

et al. 2018

Child Psychology Psychiatry

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BackgroundAdult ADHD has been assumed to be a continuation of childhood‐onset ADHD. However, recent studies have identified individuals with ADHD in adulthood who have not had ADHD in childhood. Whether or not these individuals have a ‘typical’ neurodevelopmental profile is not clear.MethodsWe tested two explanations for the emergence of apparent late‐onset ADHD symptomatology using the ALSPAC epidemiological cohort, by grouping individuals according to their scores on the Strengths and Difficulties Questionnaire (SDQ) hyperactivity subscale at ages 12 and 17 years. First, we tested whether some of those with apparent late‐onset ADHD symptoms had been potentially misclassified on the basis of earlier SDQ hyperactivity scores (ages 7, 8 and 9 years) or of subthreshold symptoms at age 12 years. Second, we investigated the possibility that those with ‘genuine’ late‐onset ADHD symptoms had a delayed manifestation of the same liability that underlies childhood‐onset symptoms, by investigating whether they had a similar profile of neurodevelopmental impairments (in the domains of autistic symptomatology, language, reading, spelling, executive functioning and IQ) as those with typical childhood‐onset ADHD.Results N = 56/75 (75%) of those with apparent late‐onset ADHD had had high ADHD scores at least one point in childhood, suggesting that they may have been misclassified on the basis of their score at age 12 years. The remaining 19 individuals (25%) with genuine late‐onset ADHD symptoms did not show a profile of neurodevelopmental impairment typically seen in ADHD, instead showing similar levels of autistic symptoms, language skills, executive functioning ability and IQ to those without ADHD symptoms. The only exceptions were that this group showed reading and spelling problems at age 9 years.ConclusionsOur work suggests that this small number of individuals with genuine late‐onset symptoms may not be most appropriately considered as having a typical neurodevelopmental disorder.

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Section: Methodsmentioning

confidence: 99%

Investigating late‐onset ADHD: a population cohort investigation

Cooper

Hammerton

Collishaw

et al. 2018

Child Psychology Psychiatry

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“…ALSPAC is a longitudinal birth cohort that recruited pregnant women resident in a geographical area in the South West of England, UK, with an expected delivery date between April 1, 1991, and December 31, 1992 9, 10. The study website contains details of all available data through a fully searchable data dictionary (http://www.bris.ac.uk/alspac/researchers/data-access/data-dictionary/).…”

Section: Methodsmentioning

confidence: 99%

Bone Mineral Density Is Positively Related to Carotid Intima-Media Thickness: Findings From a Population-Based Study in Adolescents and Premenopausal Women

Frysz

Deere

Lawlor

et al. 2016

Journal of Bone and Mineral Research

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Osteoporosis and cardiovascular disease (CVD) are both common causes of morbidity and mortality. Previous studies, mainly of people older than 60 years, suggest a relationship between these conditions. Our aim was to determine the association between bone characteristics and CVD markers in younger and middle‐aged individuals. Women (n = 3366) and their adolescent offspring (n = 4368) from the UK population‐based cohort study, Avon Longitudinal Study of Parents and Children (ALSPAC), were investigated. We measured total body (TB) and hip bone mineral density (BMD), TB bone area (BA) and bone mineral content (BMC) by dual‐energy X‐ray absorptiometry (DXA), and carotid intima‐media thickness (cIMT) by high‐resolution ultrasound. Arterial distensibility was calculated as the difference between systolic and diastolic arterial diameters. Linear regression determined associations between bone exposures and cIMT (in adolescents) and both cIMT and arterial distensibility (in women), generating partial correlation coefficients. Mean (SD) age of women was 48 (4.2) years, body mass index (BMI) was 26.2 (5.0) kg/m2, and 71% were premenopausal. In confounder‐adjusted analyses (age, height, lean mass, fat mass, menopause, smoking, estrogen replacement, calcium/vitamin D supplementation, and education) TB and hip BMD were both positively associated with cIMT (0.071 [0.030, 0.112], p = 0.001; 0.063 [0.025, 0.101], p = 0.001, respectively). Femoral neck BMD and TB BMD, BMC, and BA were positively associated with arterial distensibility. Mean (SD) age of adolescents was 17 (0.4) years, BMI was 23 (4.1) kg/m2, and 44.5% were male. Total hip and TB measurements were positively associated with cIMT, with similar magnitudes of association to those found in their mothers. In contrast to most published findings, we identified weak positive associations between BMD and cIMT in predominantly premenopausal women and their adolescent offspring. We found greater femoral neck BMD and TB DXA measurements to be associated with reduced arterial stiffness. Rather than a relationship with preclinical atherosclerosis, in these relatively young populations, we speculate our associations between BMD, cIMT, and arterial distensibility may reflect a shared relationship between bone and vascular growth and development. © 2016 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

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“…All pregnant women residing in a defined area in the South West of England, with an expected date of delivery between 1st April 1991 and 31st December 1992, were eligible and 13,761 women (contributing 13,867 pregnancies) were recruited. These women have been followed over the last 19–22 years (Fraser et al., 2013). When compared with 1991 National Census Data, the ALSPAC sample was found to be similar to the UK population as a whole (Boyd et al., 2013).…”

Section: Methodsmentioning

confidence: 99%

Pathways from maternal depressive symptoms to adolescent depressive symptoms: the unique contribution of irritability symptoms

Whelan

Leibenluft

Stringaris

et al. 2015

Child Psychology Psychiatry

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BackgroundThe authors tested three possible pathways linking prenatal maternal depressive symptoms to adolescent depressive symptoms. These pathways went through childhood Irritability Symptoms, Anxiety/Depressive Symptoms or Conduct Problems.MethodData were collected from 3,963 mother–child pairs participating in the Avon Longitudinal Study of Parents and Children. Measures include maternal depressive symptoms (pre‐ and postnatal); toddler temperament (2 years); childhood (7–13 years) irritability symptoms, anxiety/depressive symptoms, conduct problems, and adolescent depressive symptoms (16 years).Results Irritability Symptoms: This pathway linked sequentially – prenatal maternal depressive symptoms, toddler temperament (high perceived intensity and low perceived adaptability), childhood irritability symptoms, and adolescent depressive symptoms. Anxiety/Depressive symptoms: This pathway linked sequentially – prenatal maternal depressive symptoms, toddler temperament (negative perceived mood), childhood anxiety/depressive symptoms, and adolescent depressive symptoms. Childhood conduct problems were not associated with adolescent depressive symptoms, above and beyond irritability symptoms and anxiety/depressive symptoms.ConclusionsResults suggest evidence for two distinct developmental pathways to adolescent depressive symptoms that involve specific early and midchildhood features.

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Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort

Cited by 2,146 publications

References 69 publications

Investigating late‐onset ADHD: a population cohort investigation

Investigating late‐onset ADHD: a population cohort investigation

Bone Mineral Density Is Positively Related to Carotid Intima-Media Thickness: Findings From a Population-Based Study in Adolescents and Premenopausal Women

Pathways from maternal depressive symptoms to adolescent depressive symptoms: the unique contribution of irritability symptoms

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