Cohabitation is associated with a greater resemblance in gut microbiota which can impact cardiometabolic and inflammatory risk

Finnicum, Casey T.; Beck, Jeffrey J.; Dolan, Conor V.; Davis, Christel M.; Willemsen, Gonneke; Ehli, Erik A.; Boomsma, Dorret I.; Davies, Gareth E.; Geus, Eco J. C. de

doi:10.1186/s12866-019-1602-8

Cited by 29 publications

(29 citation statements)

References 30 publications

(40 reference statements)

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“…Recruitment of spousal and sibling controls, done to minimize confounding, resulted in some sex and age imbalance, which was statistically adjusted for. Notably, the gut microbiota in cohabitating spouses show greater similarities compared to non‐cohabitating age‐matched male–female pairs, likely reflecting microbial sharing and shared environmental exposures 73 . Furthermore, biological sex effects on the gut microbiome appear to be inconsistent, with suggestions that other factors such as host genetics and diet may be more influential 74 .…”

Section: Discussionmentioning

confidence: 99%

Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi‐Omics

Tan

Chong

Lim

et al. 2021

Annals of Neurology

121

106

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Objective Gut microbiome alterations in Parkinson disease (PD) have been reported repeatedly, but their functional relevance remains unclear. Fecal metabolomics, which provide a functional readout of microbial activity, have scarcely been investigated. We investigated fecal microbiome and metabolome alterations in PD, and their clinical relevance. Methods Two hundred subjects (104 patients, 96 controls) underwent extensive clinical phenotyping. Stool samples were analyzed using 16S rRNA gene sequencing. Fecal metabolomics were performed using two platforms, nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography–mass spectrometry. Results Fecal microbiome and metabolome composition in PD was significantly different from controls, with the largest effect size seen in NMR‐based metabolome. Microbiome and NMR‐based metabolome compositional differences remained significant after comprehensive confounder analyses. Differentially abundant fecal metabolite features and predicted functional changes in PD versus controls included bioactive molecules with putative neuroprotective effects (eg, short chain fatty acids [SCFAs], ubiquinones, and salicylate) and other compounds increasingly implicated in neurodegeneration (eg, ceramides, sphingosine, and trimethylamine N‐oxide). In the PD group, cognitive impairment, low body mass index (BMI), frailty, constipation, and low physical activity were associated with fecal metabolome compositional differences. Notably, low SCFAs in PD were significantly associated with poorer cognition and low BMI. Lower butyrate levels correlated with worse postural instability–gait disorder scores. Interpretation Gut microbial function is altered in PD, characterized by differentially abundant metabolic features that provide important biological insights into gut–brain pathophysiology. Their clinical relevance further supports a role for microbial metabolites as potential targets for the development of new biomarkers and therapies in PD. ANN NEUROL 2021;89:546–559

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Section: Discussionmentioning

confidence: 99%

Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi‐Omics

Tan

Chong

Lim

et al. 2021

Annals of Neurology

121

106

View full text Add to dashboard Cite

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“… 6 Under normal conditions, the intestinal resident bacteria and the host’s micro-space structure form an interdependent and interacting micro-ecological system, and the intestinal micro-organism constitutes an important protective barrier against pathogens. 5 , 27 When the stability of the micro-ecological microbiota is destroyed, the intestinal colonization resistance is greatly reduced, which can lead to the colonization and invasion of potential pathogens (including conditional pathogens) in the gut. 23 , 24 In the present study, while oxaliplatin was injected, the mice were exposed to normal drinking water or hydrogen-rich water treatments, which were continued throughout the experiment.…”

Section: Discussionmentioning

confidence: 99%

Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation of Gut Microbiota

Lian¹,

Shen²,

Zhang³

et al. 2021

JPR

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Introduction Chemotherapy-induced neuropathic pain (CINP) is one of the most common complications of chemotherapeutic drugs which limits the dose and duration of potentially life-saving anticancer treatment and compromises the quality of life of patients. Our previous studies have reported that molecular hydrogen (H 2 ) can be used to prevent and treat various diseases. But the underlying mechanism remains unclear. The aim of the present study was to explore the effects of hydrogen-rich water on gut microbiota in CINP. Methods All C57BL/6J mice were divided into 4 groups: The group fed with normal drinking water and injected with saline (H 2 O + Saline), the group fed with normal drinking water and injected with oxaliplatin (H 2 O + OXA), the group fed with hydrogen-rich water and injected with saline (HW + Saline), and the group fed with hydrogen-rich water and injected with oxaliplatin (HW + OXA). The mechanical paw withdrawal threshold of the mice was tested on days 0, 5, 10, 15 and 20 after hydrogen-rich water treatment. On day 20, feces of mice from different groups were collected for microbial community diversity and structure analysis. The levels of inflammatory cytokines (TNF-α and IL-6), oxidative stress factors (OH - and ONOO - ), lipopolysaccharide (LPS) and Toll-like receptor 4 (TLR4) were detected in dorsal root ganglia (DRG), L4-6 spinal cord segments and serum by enzyme-linked immunosorbent assay. The expression of TLR4 in DRG and spinal cords was determined by Western blot. Results The results illustrated that hydrogen-rich water could alleviate oxaliplatin-induced hyperalgesia, reduce the microbial diversity and alter the structure of gut microbiota, reverse the imbalance of inflammatory cytokines and oxidative stress, and decrease the expression of LPS and TLR4. Conclusion Hydrogen-rich water may alleviate CINP by affecting the diversity and structure of the gut microbiota, and then the LPS-TLR4 pathway, which provides a direction for further research.

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“…Therefore, we may not definitely conclude that a similar pattern holds for metabolite levels. Moreover, in general for studies including adult samples, the question arises what the common environment comprises (Finnicum et al, 2019;Zaitlen et al, 2013). In adult twin pairs living apart the common environment may represent lasting influences of their time spend living together.…”

Section: Discussionmentioning

confidence: 99%

Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data

et al. 2020

Self Cite

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AbstractMetabolites are small molecules involved in cellular metabolism where they act as reaction substrates or products. The term ‘metabolomics’ refers to the comprehensive study of these molecules. The concentrations of metabolites in biological tissues are under genetic control, but this is limited by environmental factors such as diet. In adult mono- and dizygotic twin pairs, we estimated the contribution of genetic and shared environmental influences on metabolite levels by structural equation modeling and tested whether the familial resemblance for metabolite levels is mainly explained by genetic or by environmental factors that are shared by family members. Metabolites were measured across three platforms: two based on proton nuclear magnetic resonance techniques and one employing mass spectrometry. These three platforms comprised 237 single metabolic traits of several chemical classes. For the three platforms, metabolites were assessed in 1407, 1037 and 1116 twin pairs, respectively. We carried out power calculations to establish what percentage of shared environmental variance could be detected given these sample sizes. Our study did not find evidence for a systematic contribution of shared environment, defined as the influence of growing up together in the same household, on metabolites assessed in adulthood. Significant heritability was observed for nearly all 237 metabolites; significant contribution of the shared environment was limited to 6 metabolites. The top quartile of the heritability distribution was populated by 5 of the 11 investigated chemical classes. In this quartile, metabolites of the class lipoprotein were significantly overrepresented, whereas metabolites of classes glycerophospholipids and glycerolipids were significantly underrepresented.

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Cohabitation is associated with a greater resemblance in gut microbiota which can impact cardiometabolic and inflammatory risk

Cited by 29 publications

References 30 publications

Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi‐Omics

Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi‐Omics

Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation of Gut Microbiota

Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data

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