Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy

Network, clinical and sociodemographic features of cognitive phenotypes in temporal lobe epilepsy

“…But some incongruities in the classic model have accumulated over the years, in part due to studies involving broad-based neuropsychological assessment comprehensively overviewing human cognition as well as by head-to-head cognitive comparisons of epilepsy syndromes. Rather than the expected selective cognitive abnormalities linked to syndrome-specific pathophysiology, either a) more widespread and arguably unexpected cognitive anomaly has been reported when epilepsy syndromes are studied in depth (e.g., generalized cognitive abnormalities in focal epilepsies) ( Braakman et al, 2015 , Guimaraes et al, 2007 , Hwang et al, 2019 , Marques et al, 2007 , Oyegbile et al, 2004 , Rzezak et al, 2007 ) or, b) in head-to-head comparisons of two or more epilepsy syndromes, considerably shared versus unique syndrome-specific cognitive abnormality is notable ( Baxendale and Thompson, 2010 , Braakman et al, 2015 , Bremm et al, 2019 , Guimaraes et al, 2007 , Hwang et al, 2019 , Jackson et al, 2013 , Marques et al, 2007 , Oyegbile et al, 2004 , Rzezak et al, 2007 , Smith, 2016 , Wang et al, 2011 ), or c) particular cognitive impairments (e.g., dysexecutive function) have been found to cut across multiple epilepsy syndromes ( Conant et al, 2010 , Neri et al, 2012 , Stretton and Thompson, 2012 , Verche et al, 2018 , Verrotti et al, 2015 , Wandschneider et al, 2012 ).…”

“…Here we continue to address the overarching hypothesis that cognition in epilepsy exhibits a taxonomy that only partially overlaps with syndrome-specific expectations. Our first aim is to identify the underlying cognitive phenotypes in a large group of participants with TLE from the Epilepsy Connectome Project (ECP) ( Cook et al, 2019 , Hwang et al, 2019 ). These patients are more representative of the general population of TLE patients as only a subset are medication-resistant and in need of surgical evaluation or eventual surgery.…”

CREB Protects against Temporal Lobe Epilepsy Associated with Cognitive Impairment by Controlling Oxidative Neuronal Damage

“…In TLE, seizures in the brain begin in the temporal lobes, which process emotions and short-term memory. Previous studies revealed that cognitive impairment with memory decline is a common comorbidity of TLE [3][4][5]. However, the molecular mechanisms underlying TLE-associated cognitive dysfunction remain largely unclear [6].…”

Teste Dos Cinco Dígitos E Teste De Trilhas Na Avaliação Das Funções Executivas De Pacientes Com Diagnóstico De Epilepsia

“…Existe uma forte relação entre QI e exclusão dos principais sistemas escolares. Além disso, até 48% das crianças com epilepsia podem atender aos critérios psicométricos para dificuldades de aprendizagem(HWANG et al, 2019).Tais características vão de encontro ao proposto pela literatura, em que os distúrbios convulsivos estão associados a um risco cognitivo aumentado, onde a distribuição dos escores de QI em pacientes epilépticos tendem a seguir a direção de valores mais baixos(JONES-GOTMAN et al, 2010).Os resultados alcançados pela avaliação neuropsicológica permitem conclusões objetivas acerca dos efeitos das crises epilépticas nas funções cognitivas, do efeito do fármaco proposto na cognição e verificação da eficácia da terapia proposta quando comparados em uma possível reavaliação. When abusive and harmful to health, these behaviors can fit into the DSM classifications and typologies, being considered pathology.…”