Cognitive skill learning in multiple sclerosis: A meaningful component of the neuropsychological profile

Covey, Thomas J.; Shucard, Janet L.; Wang, Xuedi; Gregory, Madeline A.; Shucard, David W.

doi:10.1016/j.bandc.2023.105959

Cited by 1 publication

(2 citation statements)

References 62 publications

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“…These results are similar to previous studies which report that participants with initial higher WM ability obtain more benefits from WM training. 10 – 12 Likewise, only WM/IP preserved showed near transfer effects to other tests designed to assess WM/IP functions such as PASAT and SDMT.…”

Section: Discussionmentioning

confidence: 91%

“…Considering the results previously observed in our laboratory, 8 the main aim of this study was to explore the influence of clinical and radiological variables on predicting the positive effects of WM/IP training in a sample of PwMS with different cognitive statuses. Based on the results of previous studies, [9][10][11][12] we specifically hypothesized that PwMS with preserved WM/IP abilities and/ or less gray matter atrophy in brain areas sustaining WM would benefit more from this training program.…”

Section: Introductionmentioning

confidence: 99%

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Pre-training working memory/information processing capabilities and brain atrophy limit the improving effects of cognitive training

Esbrí,

Sebastián Tirado,

Zaragoza Mezquita

et al. 2023

Multiple Sclerosis Journal - Experimental, Translational and Cl

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Background Computerized training in persons with multiple sclerosis (PwMS) seems to enhance working memory (WM)/information processing (IP), but factors associated with the efficacy of the treatment have not been sufficiently explored. Objective: To identify clinical and radiological characteristics associated with positive WM/IP training responses. Methods Radiological and neuropsychological assessments were carried out on a sample of 35 PwMs who were divided into “WM/IP-impaired” and “WM/IP-preserved.” All participants underwent adaptive n-back training for 10 days and were assessed post-training. Between-group differences (“WM/IP-impaired” vs. “WM/IP-preserved”) in training-induced cognitive improvement were assessed and exploratory correlational/ regression-based methods were employed to assess the relationship between cognitive improvement and clinical and radiological variables. Results All PwMS exhibited WM/IP benefits after training, but those with preserved WM/IP functions showed greater positive effects as well as transfer effects to other WM/IP tests when compared to the impaired group. Additional analyses revealed that positive response to treatment was associated with WM/IP baseline capabilities and greater gray matter volume (GMVOL) in relevant areas such as the thalamus. Conclusions Restorative cognitive training is suitable to improve cognition in PwMS but its effective outcome differs depending on the baseline WM/IP capabilities and GMVOL.

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Section: Discussionmentioning

confidence: 91%