Cognitive Performance of Patients with Epilepsy and Calcified Neurocysticercotic Lesions: A Case–Control Study

Boppré, M.C.P; Wille, Paulo Roberto; Guarnieri, Ricardo; Rezek, Karinne; Carqueja, Cristiane Lima; Trevisol-Bittencourt, Paulo César; Walz, Julio Cesar; Bianchin, Marino M.; Wangenheim, Aldo von; Chaves, Márcia Lorena Fagundes; Walz, Roger

doi:10.1006/ebeh.2001.0270

Cited by 12 publications

(10 citation statements)

References 24 publications

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“…[7][8][9] In an uncontrolled study, Forlenza et al 7 suggested that NCC could also be an important cause of cognitive impairment. In contrast, Boppré et al, 4 in a recent case-control study, observed similar cognitive performance in focal epilepsy patients with and without chronic NCC. The limitations of their study were the lack of high resolution MRI studies and of ictal recordings, making the precise diagnosis of the epileptic syndrome and the establishment of the causal relationship between NCC and epilepsy difficult.…”

mentioning

confidence: 78%

Cognitive performance of patients with mesial temporal lobe epilepsy and incidental calcified neurocysticercosis

Coimbra¹,

Rezek²,

Escorsi-Rosset³

et al. 2005

Journal of Neurology, Neurosurgery & Psychiatry

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Objectives: Although chronic calcified neurocysticercosis (NCC) has been considered a major cause of symptomatic epilepsy in developing countries, it can also be an incidental pathological finding in epileptic patients from endemic regions. The mechanisms of brain plasticity occurring in patients with NCC during and after the inflammatory process related to the parasite infection, death, degeneration, and calcification within the host brain might be an independent factor for cognitive impairment in patients with NCC and epilepsy. In order to assess this possibility cognitive performance of patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) with and without NCC was investigated through structured neuropsychological testing. Methods: Cognitive performance of long term MTLE-HS patients with (HS-NCC group, n = 32) and without NCC (HS only, n = 48) was compared. Imbalances between the two groups with respect to clinical, demographic, neuroimaging, and electrophysiological variables were adjusted by linear multiple regression analysis and Bonferroni correction for multiple tests. Results and conclusions: There were no cognitive performance differences between HS-NCC and HS only patients, leading to the conclusion that chronic calcified NCC per se does not aggravate the cognitive performance of patients with long term MTLE-HS.

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mentioning

confidence: 78%

Cognitive performance of patients with mesial temporal lobe epilepsy and incidental calcified neurocysticercosis

Coimbra¹,

Rezek²,

Escorsi-Rosset³

et al. 2005

Journal of Neurology, Neurosurgery & Psychiatry

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“…[21][22][23][24][25][26] NCC can cause neuropsychiatric symptoms, the most common being seizures occurring in 70-92% of patients. 2,[27][28][29][30][31] In endemic regions, it is not uncommon to observe patients with chronic calcified neurocysticercosis (cNCC) associated with MTLE-HS. [32][33][34][35] Although the association between cNCC and MTLE-HS might be coincidental in many patients due to the elevated prevalence of both disorders in some populations, growing evidence suggests that NCC can be also involved in the pathogenesis of MTLE-HS.…”

Section: Introductionmentioning

confidence: 99%

On the relationship between neurocysticercosis and mesial temporal lobe epilepsy associated with hippocampal sclerosis: coincidence or a pathogenic relationship?

Bianchin

Velasco

Santos

et al. 2012

Pathogens and Global Health

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Neurocysticercosis (NCC) and mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS) are two common worldwide forms of focal epilepsy. In regions where NCC is endemic, both diseases can be observed in the same patient. There is recent and growing evidence suggesting that NCC might contribute to or even cause MTLE-HS. In this article, we review the literature regarding NCC and temporal lobe epilepsy, specifically addressing the relationship between NCC and MTLE-HS. In addition, we review some scenarios where NCC seems to emerge as a causative agent or contributor to the development of MTLE-HS in some patients. This association is important because it may have an impact on the evaluation and treatment of a sizable proportion of patients with epilepsy. Insights from these clinical observations might also contribute to the understanding of the neurobiology of both NCC and MTLE-HS. We hope that our review might shed some light on this interesting interplay between two of the most common worldwide conditions associated with human focal epilepsy.

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“…Nas zonas endêmicas de países em desenvolvimento, como o Brasil, a NCC tem sido considerada como importante causa de epilepsia e outros sintomas neurológicos 6,7 . A epilepsia resulta de agressões ao encéfalo e caracteriza-se por desencadear desde simples perda de atenção (hipoproxia) até convulsões severas 8,9 . No Brasil, poucos são os trabalhos que ressaltam a importância da NCC na etiologia da epilepsia e de outras alterações neurológicas 10 .…”

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Perfil clínico-epidemiológico de pacientes com neurocisticercose atendidos no Hospital Universitário Regional de Maringá, Paraná, Brasil

Benedeti

Falavigna

Falavigna-Guilherme

et al. 2007

Arq. Neuro-Psiquiatr.

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Este estudo propõe-se verificar o perfil clínico-epidemiológico da neurocisticercose (NCC) em pacientes atendidos no Hospital Universitário Regional de Maringá. Foram analisados 6100 prontuários dos setores de Neurologia, Neuropediatria, Neurocirurgia e Psiquiatria, de janeiro/1998 a dezembro/2004. Destes, foram selecionados 48 com diagnóstico de NCC. O número de casos de NCC observados superou aqueles notificados à Vigilância Epidemiológica nos anos de 1998, 1999, 2001, 2002 e 2004. Houve predomínio do gênero feminino (p<0,001), com idade entre 31-60 anos (43,7%) e residentes na zona urbana (93,8%). A epilepsia por NCC (IC=1,77;16,07; p=0,0024) foi de início tardio e generalizada em 91,7% dos pacientes, estando associada a cefaléia em 37,5% dos pacientes. Houve necessidade de internação em 22,9% dos pacientes, com tempo médio de internação de 3,91±3,35dias. Concluiu-se que o perfil clínico-epidemiológico observado é peculiar, apresentando alguns pontos em comum com estudos conduzidos em outras regiões endêmicas brasileiras.

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Cognitive Performance of Patients with Epilepsy and Calcified Neurocysticercotic Lesions: A Case–Control Study

Cited by 12 publications

References 24 publications

Cognitive performance of patients with mesial temporal lobe epilepsy and incidental calcified neurocysticercosis

Cognitive performance of patients with mesial temporal lobe epilepsy and incidental calcified neurocysticercosis

On the relationship between neurocysticercosis and mesial temporal lobe epilepsy associated with hippocampal sclerosis: coincidence or a pathogenic relationship?

Perfil clínico-epidemiológico de pacientes com neurocisticercose atendidos no Hospital Universitário Regional de Maringá, Paraná, Brasil

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