Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity

Fardell, Joanna E.; Vardy, Janette; Shah, Jeanette D.; Johnston, Ian

doi:10.1007/s00213-011-2466-2

Cited by 99 publications

(67 citation statements)

References 57 publications

(86 reference statements)

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“…By convention, we have induced bifurcation by introducing the animals to a novel wheel at the start of one of the scotophases [2], and therefore wheels were used in our protocol. Running wheels have been shown to change the organization of sleep [44], increase learning [45,46] and synaptic plasticity [47], and rescue induced learning deficits [48,49]. While it is unknown whether the wheels may have compensated for small decrements dependent on sleep or other variables, the fact that our protocol was sensitive to differences in circadian manipulation (Experiment 1) and phase (Experiment 2) in control animals indicates that the wheels did not create a general ceiling effect.…”

Section: Interval Effects Were Found For Control Mice But Not Bifurcmentioning

confidence: 92%

Circadian waveform bifurcation, but not phase-shifting, leaves cued fear memory intact

Harrison

Carmack

Block

et al. 2017

Physiology & Behavior

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• The circadian system was experimentally bifurcated into two days and nights per 24 h.• Pavlovian fear conditioning was used to quantify acquisition and retrieval of memory.• Retrieval of cued fear remained intact in bifurcated, but not phase-shifted, mice. a b s t r a c t a r t i c l e i n f o In mammals, memory acquisition and retrieval can be affected by time of day, as well as by manipulations of the light/dark cycle. Under bifurcation, a manipulation of circadian waveform, two subjective days and nights are experimentally induced in rodents. We examined the effect of bifurcation on Pavlovian fear conditioning, a prominent model of learning and memory. Here we demonstrate that bifurcation of the circadian waveform produces a small deficit in acquisition, but not on retrieval of fear memory. In contrast, repeated phase-shifting in a simulated jet-lag protocol impairs retrieval of memory for cued fear. The results have implications for those attempting to adjust to shift-work or other challenging schedules.

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Section: Interval Effects Were Found For Control Mice But Not Bifurcmentioning

confidence: 92%

Circadian waveform bifurcation, but not phase-shifting, leaves cued fear memory intact

Harrison

Carmack

Block

et al. 2017

Physiology & Behavior

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“…Further, the combination of oxaliplatin ? 5-fluorouracil produces deficits in novel object recognition 2 weeks following exposure [131] and methotrexate produces deficits in novel object recognition 4 weeks following a single exposure [129] indicating that these effects can persist.…”

Section: Recognition Memorymentioning

confidence: 97%

“…Neonatal exposure to methotrexate can impair the development of conditioned emotional responding when assessed in young animals [144]. In adult animals, a single exposure to oxaliplatin and 5-fluorouracil results in deficits in contextual fear contitioning 4 weeks following exposure [131] and repeated exposure to cyclophosphamide and doxorubicin leads to impairments in contextual fear conditioning that persist for at least 1 week following the final exposure [145]. Additionally, repeated temozolomide exposure impairs acquisition of a classically conditioned eyeblink response [92].…”

Section: Associative Learning and Memorymentioning

confidence: 97%

Potential Use of Nicotinic Receptor Agonists for the Treatment of Chemotherapy-Induced Cognitive Deficits

Philpot

2015

Neurochem Res

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Over the past several decades, research in both humans and animals has established the existence of persistent cognitive deficits resulting from exposure to chemotherapeutic agents. Nevertheless, there has been very little research addressing the treatment of chemotherapy-induced cognitive deficits and there is currently no approved treatment for this condition, often referred to as 'chemo-brain.' Several drugs that enhance cholinergic function and/or increase nicotinic acetylcholine receptor (nAChR) activity have been demonstrated to improve cognitive performance and/or reverse cognitive deficits in animals, findings that have led to the use of these compounds to treat the cognitive deficits present in a variety of disorders including attention deficit disorder, Alzheimer's disease, Parkinson's disease and schizophrenia. Although nAChR agonists have not been assessed for their efficacy in treating chemotherapy-induced cognitive deficits, these drugs have been shown to produce measureable increases in performance on several behavioral tasks known to be disrupted by exposure to chemotherapeutic agents. While the processes underlying chemotherapy-induced cognitive deficits may differ from those underlying other disorders, there appears to be a broad spectrum of application for the use of nAChR agonists to improve cognitive function. Therefore, studies examining the use of these drugs in the treatment of chemotherapy-induced cognitive deficits should be conducted as they may be of benefit for the treatment of 'chemo-brain.'

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“…shown to be beneficial for managing people with all types of cancer [106][107][108], and its therapeutic efficacy was reported among cancer patients of all ages [109] undergoing surgery, chemotherapy or radiotherapy [110] for improving biological and psychosocial [111] functions.…”

Section: Physical Activity: Physical Activity In Itself Wasmentioning

confidence: 99%

Assessment and Treatment of Chemotherapy-induced Peripheral Neuropathy- a Physical Therapy Perspective

Kumar

Jamwal

2015

GJCT

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Chemotherapy is recognized as a mainline treatment for all types of cancer, and its most debilitating and dose-limiting complication is Chemotherapy-induced peripheral neuropathy (CIPN), the mechanisms of nerve damage of which depends upon the specific chemotherapeutic agent used. Use of non-invasive treatment methods such as physical therapy may provide a valuable therapeutic adjunctive option in patients with CIPN. Physical therapy treatment methods had been shown to produce effective symptom control and enhance quality of life in palliative care. A detailed evidence-based update of literature is provided under evaluation and management of CIPN with a special perspective of physical therapy management using a proposed clinical reasoning-based treatment decision making algorithm so that an Ã¢â‚¬Ëœout of the boxÃ¢â‚¬â„¢ self-reflective evidence-informed critical thinking process is applied along a collaborative multidisciplinary biopsychosocial approach.Ã‚Â Keywords: Chemotherapy-induced neurotoxicity; Chemotherapy-induced neuropathy; Physical therapy; Palliative rehabilitation

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Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity

Cited by 99 publications

References 57 publications

Circadian waveform bifurcation, but not phase-shifting, leaves cued fear memory intact

Circadian waveform bifurcation, but not phase-shifting, leaves cued fear memory intact

Potential Use of Nicotinic Receptor Agonists for the Treatment of Chemotherapy-Induced Cognitive Deficits

Assessment and Treatment of Chemotherapy-induced Peripheral Neuropathy- a Physical Therapy Perspective

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