Cognitive impairment and drug responsiveness in mesial temporal lobe epilepsy

Uslu, Sibel Çeliker; Yüksel, Burcu; Tekin, Betül; Sariahmetoğlu, Hande; Atakli, Dilek

doi:10.1016/j.yebeh.2018.10.034

Cited by 31 publications

(17 citation statements)

References 48 publications

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“…We found that 41% of our patients had verbal memory impairment at 30‐minute delay, suggesting severe hippocampal dysfunction. As most patients (18 of 20) had an EZ including mesial temporal lobe, these results are consistent with previous works demonstrating verbal memory impairment in patients with mesial TLE . ALF was seen in 29.5% of our patients, which is consistent with a previous work that found ALF in 18% of patients with probably less severe TLE …”

Section: Discussionsupporting

confidence: 93%

Hippocampal Interictal Spikes during Sleep Impact Long‐Term Memory Consolidation

Lambert

Tramoni-Negre

Lagarde

et al. 2020

Annals of Neurology

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Objective: Non-rapid eye movement (NREM) sleep is supposed to play a key role in long-term memory consolidation transferring information from hippocampus to neocortex. However, sleep also activates epileptic activities in medial temporal regions. This study investigated whether interictal hippocampal spikes during sleep would impair long-term memory consolidation. Method: We prospectively measured visual and verbal memory performance in 20 patients with epilepsy investigated with stereoelectroencephalography (SEEG) at immediate, 30-minute, and 1-week delays, and studied the correlations between interictal hippocampal spike frequency during waking and the first cycle of NREM sleep and memory performance, taking into account the number of seizures occurring during the consolidation period and other possible confounding factors, such as age and epilepsy duration. Results: Retention of verbal memory over 1 week was negatively correlated with hippocampal spike frequency during sleep, whereas no significant correlation was found with hippocampal interictal spikes during waking. No significant result was found for visual memory. Regression tree analysis showed that the number of seizures was the first factor that impaired the verbal memory retention between 30 minutes and 1 week. When the number of seizures was below 5, spike frequency during sleep higher than 13 minutes was associated with impaired memory retention over 1 week. Interpretation: Our results show that activation of interictal spikes in the hippocampus during sleep and seizures specifically impair long-term memory consolidation. We hypothesize that hippocampal interictal spikes during sleep interrupt hippocampal-neocortical transfer of information.

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Section: Discussionsupporting

confidence: 93%

Hippocampal Interictal Spikes during Sleep Impact Long‐Term Memory Consolidation

Lambert

Tramoni-Negre

Lagarde

et al. 2020

Annals of Neurology

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“…Temporal glioma-induced topological properties of the visual network were altered. Epilepsy can induce cortical sclerosis ( 29 ), gray matter atrophy ( 30 ), and cortical hypometabolism ( 31 ), resulting in decreased global efficiency and increased shortest path lengths in patients with epilepsy. Compared to that in healthy controls, global efficiency and shortest path lengths were not significantly altered in patients with temporal glioma and GRE.…”

Section: Discussionmentioning

confidence: 99%

Epilepsy-Related Brain Network Alterations in Patients With Temporal Lobe Glioma in the Left Hemisphere

et al. 2020

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Background: Seizures are a common symptom in patients with temporal lobe gliomas and may result in brain network alterations. However, brain network changes caused by glioma-related epilepsy (GRE) remain poorly understood. Objective: In this study, we applied graph theory analysis to delineate topological networks with resting-state functional magnetic resonance images (rs-fMRI) and investigated characteristics of functional networks in patients with GRE. Methods: Thirty patients with low-grade gliomas in the left temporal lobe were enrolled and classified into GRE (n = 15) and non-GRE groups. Twenty healthy participants matched for age, sex, and education level were enrolled. All participants had rs-fMRI data. Sensorimotor, visual, default mode, auditory, and right executive control networks were used to construct connection matrices. Topological properties of those sub-networks were investigated. Results: Compared to that in the GRE group, four edges with higher functional connectivity were noted in the non-GRE group. Moreover, 21 edges with higher functional connectivity were identified in the non-GRE group compared to the healthy group. All significant alterations in functional edges belong to the visual network. Increased global efficiency and decreased shortest path lengths were noted in the non-GRE group compared to the GRE and healthy groups. Compared with that in the healthy group, nodal efficiency of three nodes was higher in the GRE and non-GRE groups and the degree centrality of six nodes was altered in the non-GRE group. Conclusion: Temporal lobe gliomas in the left hemisphere and GRE altered visual networks in an opposing manner. These findings provide a novel insight into brain network alterations induced by GRE.

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“…Cognitive impairment is a widespread phenomenon among TLE patients (Celiker, Yuksel, Tekin, Sariahmetoglu, & Atakli, ; Jokeit, Luerding, & Ebner, ). According to behavioral research, rTLE patients have significantly lower intrinsic alertness and phasic alertness RTs than healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

Resting‐state brain entropy in right temporal lobe epilepsy and its relationship with alertness

et al. 2019

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BackgroundTo date, no functional MRI (fMRI) studies have focused on brain entropy in right temporal lobe epilepsy (rTLE) patients. Here, we characterized brain entropy (BEN) alterations in patients with rTLE using resting‐state functional MRI(rs‐fMRI) and explored the relationship between BEN and alertness.MethodThirty‐one rTLE patients and 33 controls underwent MRI scanning to investigate differences in BEN and resting‐state functional connectivity (rs‐FC) in regions of interest (ROIs) between patients and controls. Correlation analyses were performed to examine relationships between the BEN of each ROI and alertness reaction times (RTs) in rTLE patients.ResultsCompared with controls, the BEN of rTLE patients was significantly increased in the right middle temporal gyrus, inferior temporal gyrus, and other regions of the left hemisphere and significantly decreased in the right middle frontal gyrus and left supplementary motor area (p < .05). The rs‐FCs between the ROIs (at p < .01, with the left superior parietal lobule and right precentral gyrus defined as ROI1 and ROI2, respectively) and the whole brain showed an increasing trend in rTLE patients. In addition, the BEN of ROI2 was associated with the intrinsic alertness and phasic alertness RTs of patients with rTLE.ConclusionsOur findings suggest that BEN is altered in patients with rTLE and that decreased BEN in the right precentral gyrus is positively related to intrinsic and phasic alertness; the abnormal FC in the brain regions with altered entropy suggests a reconstruction of brain functional connectivity. These findings suggest that BEN mapping may provide a useful tool for probing brain mechanisms related to TLE.

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Cognitive impairment and drug responsiveness in mesial temporal lobe epilepsy

Cited by 31 publications

References 48 publications

Hippocampal Interictal Spikes during Sleep Impact Long‐Term Memory Consolidation

Hippocampal Interictal Spikes during Sleep Impact Long‐Term Memory Consolidation

Epilepsy-Related Brain Network Alterations in Patients With Temporal Lobe Glioma in the Left Hemisphere

Resting‐state brain entropy in right temporal lobe epilepsy and its relationship with alertness

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