Cognitive Estimation in Non-demented Parkinson's Disease

Scarpina, Federica; Mauro, Alessandro; D’Aniello, Guido Edoardo; Albani, Giovani; Castelnuovo, Gianluca; Ambiel, Erika; MacPherson, Sarah E.

doi:10.1093/arclin/acx019

Cited by 6 publications

(7 citation statements)

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“…As the total score of NADL is obtained by the combination of all tasks included in the battery, overall worse performance may be related both to failure in the written operations task but also to slightly worse performance in all other tasks (see Table S2). Although these findings are consistent with previous evidence [11], the observed differences may be also related to the presence of cognitive impairments in our PD sample. In fact, PD patients obtained lower performances in MMSE compared to HC.…”

Section: Discussionsupporting

confidence: 93%

“…Recently, longer duration of the disease and more impaired global cognition were reported to be associated with a higher rate of arithmetic deficits, which were also predicted by impairments in the attention and visuospatial/constructional domains [10]. Moreover, Scarpina and collaborators [11] found that PD patients had an impaired performance on the Graded Difficulty Arithmetic task, which correlated with the outcome of numerical estimation tasks.…”

Section: Introductionmentioning

confidence: 96%

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Neurocognitive correlates of numerical abilities in Parkinson’s disease

et al. 2022

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Peoplewith Parkinson's disease (PD) experience functional limitations early in the progression of the disease, showing, among other cognitive deficits, difficulties in mathematical abilities. The neural correlates of such abilities have been scarcely investigated in PD, and it is not known whether patients may exhibit difficulties only in formal numerical tasks (e.g., mental multiplications), or also in everyday activities involving numbers (i.e., informal numerical abilities such as time estimates). The present study investigated formal and informal numerical abilities in PD patients and explored their relationship with cortical and subcortical brain volume. We examined patients with PD and mild cognitive impairment (PD-MCI) and age-matched healthy controls (HCs) using the numerical activities of daily living (NADL) battery, assessing both scholastic numerical abilities (formal test), and the ability to use numbers in everyday life (informal test). We compared NADL performances in both groups. Within the PD group, we investigated the association between NADL and cortical and subcortical volumes using multiple linear regressions. The correlation with other cognitive tests was also explored. PD-MCI performed worse than HC in the formal NADL test. In PD-MCI patients, brain-behavior correlations showed two distinct patterns: cortical volumes correlated positively, while striatal volumes correlated negatively with NADL formal tasks. Both formal and informal tests correlated with measures of cognitive functioning. Our results suggest specific impairments in formal numerical abilities in PD-MCI, but not in everyday activities. While cortical atrophy is associated with worse performance, the negative correlations with subcortical regions suggest that their activation may reflect potential compensatory mechanisms. KeywordsCognitive impairment • MCI • Numerical abilities of daily living • Neuroimaging • Basal ganglia • Activities of daily living * Francesca Burgio

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 96%

Neurocognitive correlates of numerical abilities in Parkinson’s disease

et al. 2022

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“…Even though one might expect arithmetic deficits to have been assessed thoroughly given the extensive profiling of cognitive impairment in PD, research is scarce (e.g., Kalbe, 1999;Tamura et al, 2003). Unsystematic clinical observations show arithmetic errors in both advanced PDD (Kalbe, 1999) and non-demented PD patients (Tamura et al, 2003;Zamarian et al, 2006;Scarpina et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Arithmetic Errors in Financial Contexts in Parkinson’s Disease

et al. 2021

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Research on dyscalculia in neurodegenerative diseases is still scarce, despite high impact on patients’ independence and activities of daily living function. Most studies address Alzheimer’s Disease; however, patients with Parkinson’s Disease (PD) also have a higher risk for cognitive impairment while the relation to arithmetic deficits in financial contexts has rarely been studied. Therefore, the current exploratory study investigates deficits in two simple arithmetic tasks in financial contexts administered within the Clinical Dementia Rating in a sample of 100 PD patients. Patients were classified as cognitively normal (PD-NC) or mildly impaired (PD-MCI) according to Level I consensus criteria, and assessed using a comprehensive neuropsychological test battery, neurological motor examination, and sociodemographic and clinical questionnaires. In total, 18% showed arithmetic deficits: they were predominately female, had longer disease duration, more impaired global cognition, but minor signs of depression compared to PD patients without arithmetic deficits. When correcting for clinical and sociodemographic confounders, greater impairments in attention and visuo-spatial/constructional domains predicted occurrence of arithmetic deficits. The type of deficit did not seem to be arbitrary but seemed to involve impaired place × value processing frequently. Our results argue for the importance of further systematic investigations of arithmetic deficits in PD with sensitive tests to confirm the results of our exploratory study that a specific subgroup of PD patients present themselves with dyscalculia.

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“…Moreover, the task was self-paced; it would be interesting to perform the tasks in different (self-paced vs external-paced) modalities, but it should be taken into account that the overall accuracy and stability of movements can be negatively influenced by attentional processing enhanced by the presence of external cueing in PD (Almeida et al., 2005). Finally, the possible effect related to lateralization of symptoms, meaning which body part side was the most affected by disease, in relation to the dominance handedness, as well as the role of cognitive difficulties in PD (Litvan et al., 2011) and specifically in cognitive estimation (D’Aniello et al., 2015a,b; Scarpina et al., 2017) should be considered. Future research needs to overcome these limitations, where possible.…”

Section: Discussionmentioning

confidence: 99%

Defective Tool Embodiment in Body Representation of Individuals Affected by Parkinson’s Disease: A Preliminary Study

et al. 2019

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When efficiently used for action, tools become part of the body, with effect on the spatial-temporal movement parameters and body size perception. Until now, no previous investigation has been reported about tool embodiment in Parkinson’s disease (PD), which is a neurological disease characterized by several sensory and motor symptoms affecting body and action. We enrolled 14 individuals affected by PD and 18 healthy individuals as controls. We studied the spatial-temporal parameters on self-paced free pointing movement task, via an optoelectronic system, before and after a short training in which a 27-cm long rod was used to point toward a far target. Moreover, we investigated changes in estimation of arm length through the Tactile Estimation Task. After the tool-use training, controls showed changes in spatial-temporal parameters: they were slower to perform movements and reported a higher value of deceleration than the baseline. However, such a difference did not emerge in the PD individuals. In the Tactile Discrimination Task, no difference emerged before and after the tool-use training in both groups. Our results were suggestive of possible difficulties of the tool embodiment process in PD. We discussed our results in relation to aberrant multisensory integration as well as in terms of the effect of PD sensory and motor symptoms on body schema plasticity. The present study points at a novel way to conceive PD sensory motor signs and symptoms in terms of their effect on individuals’ body representation.

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Cognitive Estimation in Non-demented Parkinson's Disease

Abstract: Background: The Cognitive Estimation Test (CET) is widely used in clinical and research settings

Cited by 6 publications

References 42 publications

Neurocognitive correlates of numerical abilities in Parkinson’s disease

Neurocognitive correlates of numerical abilities in Parkinson’s disease

Arithmetic Errors in Financial Contexts in Parkinson’s Disease

Defective Tool Embodiment in Body Representation of Individuals Affected by Parkinson’s Disease: A Preliminary Study

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