Cognitive effects of insulin in the central nervous system

Park, C.R

doi:10.1016/s0149-7634(01)00016-1

Cited by 235 publications

(164 citation statements)

References 187 publications

Supporting

Mentioning

159

Contrasting

Unclassified

Order By: Relevance

“…This result robustly replicates the beneficial effect of intranasal insulin on declarative memory seen in normal-weight men and women 8,9 as well as findings in animals where intracerebroventricular administration of the compound enhanced memory functions. 5,27 Declarative memory comprises the acquisition and recall of facts and events. Its formation relies primarily on Brain insulin signaling in obesity M Hallschmid et al hippocampal structures and adjacent cortices 18 where brain insulin receptors are predominantly found.…”

Section: Discussionmentioning

confidence: 99%

“…28 In these structures, insulin increases long-term potentiation and promotes neuronal outgrowth, that is, plastic mechanisms supposed to underlie memory functions at the neuronal level. 27 The slow onset of memory enhancement by intranasal insulin in the absence of acute effects speaks for the involvement of gradual plastic neuronal changes. Enhancement of neuronal glucose utilization by insulin 29 as well as the observed suppression of cortisol release may have further supported memory improvement.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Obese men respond to cognitive but not to catabolic brain insulin signaling

et al. 2007

View full text Add to dashboard Cite

Context and objective: Insulin acts in the brain to reduce food intake and body weight and is considered a major adiposity signal in energy homeostasis. In normal-weight men, intranasal insulin administration reduces body fat and improves declarative memory. The present experiments aimed to generalize these findings to obese patients, with a view to evaluate the therapeutic potential of the compound. Design, subjects and measurements: Insulin and placebo, respectively, were intranasally administered four times a day (amounting to 160 IU day À1 ) over 8 weeks to two groups of 15 obese men each. Results: Contrasting with the catabolic effects in normal-weight men, insulin treatment did not induce any significant reduction of body weight (P40.50) and body fat (P40.44) in the obese subjects. However, in accordance with the effects in normalweight men, declarative memory and mood were improved (Po0.05) and hypothalamic-pituitary-adrenal axis activity as assessed by circulating ACTH (Po0.01) and cortisol levels (Po0.04) was reduced. Conclusions: Our results indicate that in obese men, intranasal insulin is functionally active in the central nervous system but fails to affect the neuronal networks critically involved in body weight regulation. We conclude that obesity in men is associated with central nervous resistance to the adiposity signal insulin. This defect likely contributes to the persistence of obesity in spite of elevated levels of circulating insulin in obese patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Obese men respond to cognitive but not to catabolic brain insulin signaling

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Increased insulin levels during the critical period of perinatal development are suggested to be capable of inducing central nervous insulin resistance, as it was demonstrated for hypothalamic neurons regulating food intake, body weight, and metabolism (25)(26)(27). It is noteworthy that in both animal models and humans, central nervous insulin resistance is known to be associated with impaired cognitive functions, but remarkably, insulin resistance does not impair psychomotor functions (28).…”

Section: Discussionmentioning

confidence: 96%

Impact of Early Neonatal Breast-Feeding on Psychomotor and Neuropsychological Development in Children of Diabetic Mothers

et al. 2005

View full text Add to dashboard Cite

OBJECTIVE -In general, breast-feeding positively influences development of psychomotor function and cognition in children. Offspring of diabetic mothers (ODM) have delayed psychomotor and cognitive development. Recently, we observed a dose-dependent negative effect of early neonatal ingestion of breast milk from diabetic mothers (diabetic breast milk [DBM]) on the risk of overweight during early childhood. Here, we investigated the influence of early neonatal intake of DBM on neurodevelopment in ODM. RESEARCH DESIGN AND METHODS-A total of 242 ODM were evaluated for age of achieving major developmental milestones (Denver Developmental Scale) according to the volume of DBM ingested during the first week of life, using Kruskal-Wallis and Kaplan-Meier analysis.RESULTS -Children in the upper tertile of early neonatal ingestion of DBM achieved early psychomotor developmental milestones ("lifting head while prone," "following with eyes") earlier than those in lower tertiles (P ϭ 0.002). In contrast, a delay in the onset of speaking was observed in children who had ingested larger volumes of DBM compared with those with lower DBM intake (P ϭ 0.002). This negative impact of DBM ingestion was not confounded by birth characteristics, total milk intake, or socioeconomic/educational status. CONCLUSIONS -Our data indicate differential effects of early neonatal DBM ingestion on psychomotor and cognitive development. Ingesting larger compared with smaller volumes of DBM may normalize early psychomotor development in ODM but delays onset of speaking as a parameter indicative of cognitive development. This effect may result from qualitative alterations in the composition of DBM. Further studies are urgently recommended on the benefits and harms of breastfeeding in ODM. Diabetes Care 28:573-578, 2005B reast-feeding is the best way to nurture healthy-term offspring of healthy mothers. It is well known to have positive short-and long-term effects, e.g., decreased risk of obesity or type 2 diabetes (1,2). Furthermore, evidence exists of a positive influence of breast feeding on psychomotor and cognitive development (3,4), persisting into adult age (5).Positive long-term effects of breastfeeding have been attributed to the composition of breast milk, including factors promoting neurodevelopment, such as long-chain polyunsaturated fatty acids (6). However, it has rarely been considered so far whether breast-feeding is still of advantage if the mother is affected by a noncommunicable disease, e.g., a metabolic disease, which may alter the composition of breast milk.Offspring of diabetic mothers (ODM) have delayed psychomotor and cognitive development (7-10). Pathophysiologic mechanisms remain unknown. Recently, we showed that early neonatal intake of breast milk from diabetic mothers may dose-dependently lead to an increased risk of overweight and impaired glucose tolerance during early childhood (11). Here, we evaluated whether the early neonatal intake of diabetic breast milk (DBM) may also influence cognitive and psychomotor developm...

show abstract

“…Reports also indicate that insulin stimulates the entry of calcium ions which are required for the release of excitory neurotransmitters such as glutamate and acetylcholine from the pre-synaptic neurons [37]. Studies on insulin resistant experimental models have also indicated poor cognitive function which may again partly confirm the direct effects of insulin on modulating hippocampal function [38]. The effects of insulin in the hippocampus are mediated through insulin receptor signalling and insulin receptors are highly expressed in the hippocampus in comparison to other regions [39].…”

Section: Discussionmentioning

confidence: 98%

“…Animals were exposed to 5 consecutive training sessions for a period of 5 days (day [36][37][38][39][40]. Animals were taken to the behavioural room 1 hour prior to the training to allow for familiarisation to the new environment.…”

Section: Training and Learningmentioning

confidence: 99%

The Application of Pectin-Insulin Patch on Streptozotocin-Induced Diabetic Rats: Implications in the Hippocampal Function

Sibiya¹,

Mabandla²

2017

J Diabetes Metab

View full text Add to dashboard Cite

Background: Diabetics are at high risk of developing dementia associated diseases compared to non-diabetics. The learning and memory impairments manifested in diabetes are attributed to sustained hyperglycaemia. Insulin injections are beneficial in preventing and attenuating the progression of these impairments. However, undesirable effects associated with the current mode of administration remains a challenge. In this study, we evaluated the effects of pectin-insulin patch on learning and memory deficits in diabetic animals.

show abstract

Cognitive effects of insulin in the central nervous system

Cited by 235 publications

References 187 publications

Obese men respond to cognitive but not to catabolic brain insulin signaling

Obese men respond to cognitive but not to catabolic brain insulin signaling

Impact of Early Neonatal Breast-Feeding on Psychomotor and Neuropsychological Development in Children of Diabetic Mothers

The Application of Pectin-Insulin Patch on Streptozotocin-Induced Diabetic Rats: Implications in the Hippocampal Function

Contact Info

Product

Resources

About