Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson's disease

Abstract

Our findings demonstrated that patients who underwent DBS experienced declines in verbal recall and trends for declines in oral information processing 6 months following surgery, even when good motor outcome was achieved. Potential candidates should be counselled about the risk of mild frontostriatal cognitive declines following DBS to weigh the risks and benefits of surgery.

Subthalamic deep brain stimulation: clinical and neuropsychological outcomes in mild cognitive impaired parkinsonian patients

“…Contrasting neuropsychological data have been reported on PD patients treated with STN-DBS: some studies suggested that cognitive outcomes might follow the natural history of the disease [5,28] , whereas others reported an increased risk of dementia early after surgery [29,30] .…”

Depression and Anxiety Following Deep Brain Stimulation in Parkinson’s Disease: Systematic Review and Meta-Analysis

“…10,28,29,33,35,65 However, a large multicenter study 91 found that the completed suicide rate following subthalamic DBS in PD is less than 0.5%, suggesting that suicide occurrences are unlikely to influence data significantly in this regard. We found that there are no long-term studies comparing the several therapeutic strategies for PD that adequately report objective data concerning anxiety and depression.…”

Controversial Issues in Deep Brain Stimulation in Parkinson's Disease

“…More generally, normal pre-operative cognitive functioning is positively correlated with postoperative improvement in UPDRS part III at a long-term follow-up [18]. STN-DBS may still lead to a decline in cognitive and executive function even with strict inclusion criteria [24]; however, it has been suggested that sub-optimal contact stimulation (caused by the small volume of STN) is more strongly correlated with post-operative psychiatric events. Although there are still debates about post-operative psychiatric events, the possibility of increased depression and suicide risk prompts us to evaluate the patient's psychological function in detail prior to the operation.…”