Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice
Geetika Nehra,
Sasivimon Promsan,
Ruedeemars Yubolphan
et al.
Abstract:Background
Patients with Alzheimer's disease (AD) develop blood–brain barrier dysfunction to varying degrees. How aging impacts Aβ pathology, blood–brain barrier function, and cognitive decline in AD remains largely unknown. In this study, we used 5xFAD mice to investigate changes in Aβ levels, barrier function, and cognitive decline over time.
Methods
5xFAD and wild-type (WT) mice were aged between 9.5 and 15.5 months and tested for spatial learni… Show more
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