Cognitive Changes 5 Years After Coronary Artery Bypass Grafting

Abstract

The change in cognitive test performance between baseline and 5 years is likely related to several factors, including low baseline performance and practice effects. The significant decline in performance between 1 and 5 years, however, raises the possibility that a late cognitive decline may be occurring in this population. Additional studies, with the use of a nonsurgical control group, are needed to determine if the observed cognitive decline is related to bypass surgery itself, normal aging in a population with cardiovascular risk factors, or some combination of these and other factors.

Assessment of the emergence of Alzheimer's disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty1

“…In addition, any variability in diagnosis of AD would be expected to be the same throughout the population studies, and would be unlikely to bias the studies in favor of a positive result. In concert with earlier studies demonstrating POCD and brain atrophy (ventricular enlargement) following CABG, the finding of a greater risk for AD is consistent with the hypothesis of reduced neuronal reserve in an aging population [7][8][9]. In this analysis, patients undergoing CABG developed AD at nearly twice the rate as patients undergoing PTCA.…”

Assessment of the emergence of Alzheimer's disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty1

“…In addition, any variability in diagnosis of AD would be expected to be the same throughout the population studies, and would be unlikely to bias the studies in favor of a positive result. In concert with earlier studies demonstrating POCD and brain atrophy (ventricular enlargement) following CABG, the finding of a greater risk for AD is consistent with the hypothesis of reduced neuronal reserve in an aging population [7][8][9]. In this analysis, patients undergoing CABG developed AD at nearly twice the rate as patients undergoing PTCA.…”

Cognitive change 5 years after coronary artery bypass surgery.

“…This study failed to follow up 34% of the sample that were initially recruited. This is identical to one of the other 5-year follow-up studies following CABG (M. F. and less than the other study (Selnes et al, 2001), which had a 40% loss to follow-up.…”

“…This is identical to one of the other 5-year follow-up studies following CABG (M. F. Newman et al, 2001) and less than the other study (Selnes et al, 2001), which had a 40% loss to follow-up.…”

“…In this study those returning to follow-up had a higher prorated IQ than those not available to follow-up. A similar finding with those returning to follow-up having higher education is reported by Selnes et al (2001). The numbers in the follow-up studies do not make it possible to examine how these factors may interact.…”

Neurocognitive Changes After Coronary Bypass Surgery

“…A similar study was reported by our own group, 3 which also indicated a decline in neurocognitive function 5 years after cardiac surgery with CPB.…”

Assessment of the emergence of Alzheimer's disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty1

“…In addition, any variability in diagnosis of AD would be expected to be the same throughout the population studies, and would be unlikely to bias the studies in favor of a positive result. In concert with earlier studies demonstrating POCD and brain atrophy (ventricular enlargement) following CABG, the finding of a greater risk for AD is consistent with the hypothesis of reduced neuronal reserve in an aging population [7][8][9]. In this analysis, patients undergoing CABG developed AD at nearly twice the rate as patients undergoing PTCA.…”

Cognitive change 5 years after coronary artery bypass surgery.

“…This study failed to follow up 34% of the sample that were initially recruited. This is identical to one of the other 5-year follow-up studies following CABG (M. F. and less than the other study (Selnes et al, 2001), which had a 40% loss to follow-up.…”

“…This is identical to one of the other 5-year follow-up studies following CABG (M. F. Newman et al, 2001) and less than the other study (Selnes et al, 2001), which had a 40% loss to follow-up.…”

“…In this study those returning to follow-up had a higher prorated IQ than those not available to follow-up. A similar finding with those returning to follow-up having higher education is reported by Selnes et al (2001). The numbers in the follow-up studies do not make it possible to examine how these factors may interact.…”

Neurocognitive Changes After Coronary Bypass Surgery

“…A similar study was reported by our own group, 3 which also indicated a decline in neurocognitive function 5 years after cardiac surgery with CPB.…”

Assessment of the emergence of Alzheimer's disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty1

“…In addition, any variability in diagnosis of AD would be expected to be the same throughout the population studies, and would be unlikely to bias the studies in favor of a positive result. In concert with earlier studies demonstrating POCD and brain atrophy (ventricular enlargement) following CABG, the finding of a greater risk for AD is consistent with the hypothesis of reduced neuronal reserve in an aging population [7][8][9]. In this analysis, patients undergoing CABG developed AD at nearly twice the rate as patients undergoing PTCA.…”

Cognitive change 5 years after coronary artery bypass surgery.

“…This study failed to follow up 34% of the sample that were initially recruited. This is identical to one of the other 5-year follow-up studies following CABG (M. F. and less than the other study (Selnes et al, 2001), which had a 40% loss to follow-up.…”

“…This is identical to one of the other 5-year follow-up studies following CABG (M. F. Newman et al, 2001) and less than the other study (Selnes et al, 2001), which had a 40% loss to follow-up.…”

“…In this study those returning to follow-up had a higher prorated IQ than those not available to follow-up. A similar finding with those returning to follow-up having higher education is reported by Selnes et al (2001). The numbers in the follow-up studies do not make it possible to examine how these factors may interact.…”

Neurocognitive Changes After Coronary Bypass Surgery

“…A similar study was reported by our own group, 3 which also indicated a decline in neurocognitive function 5 years after cardiac surgery with CPB.…”