Background: Premenstrual syndrome (PMS) is one of the most common disorders of reproductive age, and it is reported that 90% -85% of the people are suffering from this disorder. Among the multiple symptoms of mental premenstrual syndrome, dysphoria, irritability, tension, anxiety and physical symptoms of bloating and breast pain are more common symptoms that can interfere with personal, family and community relationships. Objectives: This study aimed to evaluate the frequency of the symptoms of PMS (physical, psychological and social) and the level of self-esteem in girls with PMS in 2013. Methods: A cross-sectional study was performed on 200 girl high-school students of Shiraz city who had PMS. The study tools included demographic questionnaire, premenstrual symptoms, screening tool (PSST), (completed in two consecutive months) and Cooper Smith questionnaire. Data was analyzed by applying SPSS (version 16) and descriptive statistics.