Cognitive-Behavioral Therapy vs Risperidone for Augmenting Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder

Simpson, Helen Blair; Foa, Edna B.; Liebowitz, Michael R.; Huppert, Jonathan D.; Cahill, Shawn P.; Maher, Michael J.; McLean, Carmen P.; Bender, James F.; Marcus, Sue M.; Williams, Monnica T.; Weaver, James; Vermes, Donna; Meter, Page E. Van; Rodríguez, Carolyn I.; Powers, Mark B.; Pinto, Anthony; Imms, Patricia; Hahn, Chang Gyu; Campeas, Raphael

doi:10.1001/jamapsychiatry.2013.1932

Cited by 204 publications

(143 citation statements)

References 47 publications

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“…This study highlights the biological nature of OCD and suggests that environmental factors (i.e., familial and social variables) only become relevant after the presentation of symptoms. Biological OCD factors notwithstanding, it is clear that non-biological interventions (i.e., EX/RP) are efficacious in reducing symptoms through behavioral intervention (Simpson et al, 2013), indicating that other non-genetic factors, such as childhood family interactions, also have an impact on symptom severity. Extant research is still unclear about the degree of biological versus psychosocial contributions to the onset and maintenance of OCD.…”

Section: Overview Of Ocdmentioning

confidence: 99%

The impact of childhood family functioning on anxious, depressive, and obsessive–compulsive symptoms in adulthood among African Americans

Sawyer

Williams

Chasson

et al. 2015

Journal of Obsessive-Compulsive and Related Disorders

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Section: Overview Of Ocdmentioning

confidence: 99%

The impact of childhood family functioning on anxious, depressive, and obsessive–compulsive symptoms in adulthood among African Americans

Sawyer

Williams

Chasson

et al. 2015

Journal of Obsessive-Compulsive and Related Disorders

Self Cite

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“…However, many of the patients included were CBTnaïve before using SGAs. A study of adult OCD shows that SSRI non-responders that have not received CBT previously fare better if randomized to CBT in contrast to risperidone [68]. Thus, by taking the effects and adverse events into account, we argue that using SGAs is not a viable option unless adequate trials of CBT and SSRI have been conducted.…”

Section: Atypical Antipsychotics (Neuroleptics)mentioning

confidence: 99%

Evidence-Based Treatments in Treatment-Naïve and Treatment-Resistant Pediatric Obsessive-Compulsive Disorder

Skarphéðinsson

Ivarsson

2015

Curr Behav Neurosci Rep

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Pediatric obsessive-compulsive disorder (OCD) is a chronic, disabling, and common disorder. In this paper, we describe evidence-based treatments in treatment-naïve and treatment-refractory pediatric OCD patients. We conducted a PubMed search to identify randomized controlled trials, reviews, and expert guidelines. The evidence for cognitive behavior therapy (CBT) and specific serotonin reuptake inhibitors (SSRIs) among treatment-naïve patients is substantial and shows that both treatments are effective. Head-to-head trials in pediatric OCD only show that CBT is significantly more effective than SSRI. The evidence among CBT and SSRI non-responders is limited. One trial among CBT non-responders showed that both continued CBT and switching to an SSRI are effective strategies. Likewise, one trial among SSRI non-responders showed that augmenting with CBT is necessary. Evidence of treatments for treatment-refractory pediatric OCD is lacking. We describe the treatments available and evidence from studies of adult OCD. Evidence for emerging treatments such as modifying CBT and glutamatergic drugs is also described.

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“…Masi et al, 2013]. Vor dem Hintergrund des nicht unerheblichen Nebenwirkungsprofils von atypischen Neuroleptika erscheint eine aktuelle Untersuchung von Simpson et al [2013] bemerkenswert, in der erstmalig gezeigt werden konnte, dass zumindest bei Erwachsenen eine zusätzlich durchgeführte CBT der Augmentation von SSRI mit Risperidon überlegen war.…”

Section: Typische Behandlungsfehlerunclassified

Fortschritte in der Behandlung von Zwangsstörungen bei Kindern und Jugendlichen: Empirische Evidenz, Behandlungsprobleme und Verbesserungsmöglichkeiten

Simons

Vloet

2017

Verhaltenstherapie

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Obwohl Zwangsstörungen im Kindes- und Jugendalter mittlerweile als gut behandelbar gelten, sind die Behandlungsergebnisse in der Praxis häufig unbefriedigend. Dies liegt daran, dass nachweislich wirksame Interventionen nicht oder unzureichend angewendet werden. Die vorliegende Arbeit gibt eine Übersicht über evidenzbasierte psychotherapeutische und medikamentöse Behandlungsmöglichkeiten. Die Behandlung der Wahl ist die Kognitive Verhaltenstherapie mit Exposition und Reaktionsverhinderung, die, falls erforderlich, um eine Pharmakotherapie mit einem selektiven Serotonin-Wiederaufnahme-Hemmer ergänzt wird. Befunde zu Prädiktoren, Moderatoren und Mediatoren der Behandlung sind uneinheitlich. Neue Entwicklungen in der Psychotherapie beinhalten Anwendungen der Expositionsbehandlung, die nicht einem Habituationsrational folgen, sondern auf Angsthemmung und Angsttoleranz sowie auf kognitive (Erwartungsverletzung) oder metakognitive Veränderungen abzielen. Bei Kindern mit geringer Behandlungsmotivation und starker Einbindung der Familie in die Zwänge des Kindes sind elternbezogene Interventionen indiziert. Behandlungsfehler in der Expositionsbehandlung sollten in der Ausbildung von Kinder- und Jugendlichenpsychotherapeuten besonders berücksichtigt werden.

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Cognitive-Behavioral Therapy vs Risperidone for Augmenting Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder

Cited by 204 publications

References 47 publications

The impact of childhood family functioning on anxious, depressive, and obsessive–compulsive symptoms in adulthood among African Americans

The impact of childhood family functioning on anxious, depressive, and obsessive–compulsive symptoms in adulthood among African Americans

Evidence-Based Treatments in Treatment-Naïve and Treatment-Resistant Pediatric Obsessive-Compulsive Disorder

Fortschritte in der Behandlung von Zwangsstörungen bei Kindern und Jugendlichen: Empirische Evidenz, Behandlungsprobleme und Verbesserungsmöglichkeiten

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