Cognitive behavioral therapy for patients with mild to moderate depression: Treatment effects and neural mechanisms

Meng, Yuping; Li, Hong; Wang, Junjie; Xu, Yong; Wang, Binquan

doi:10.1016/j.jpsychires.2021.02.001

Cited by 12 publications

(12 citation statements)

References 67 publications

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“…It was suggested that aerobic exercise may Mitochondria are the energy factories in cells and the central link in the initiation or development of various diseases. Calcium overload caused by cellular Ca influx under stress has been shown to induce mitochondrial damage, increase ROS generation, and promote K + efflux (30)(31)(32), which suggests that mitochondrial damage may be the key to NLRP3 inflammasome activation. Studies have shown that irisin inhibits Ca 2+ influx (33) and reduces mitochondrial damage (34), which suggests that aerobic exercise may inhibit the progression of PSD by inhibiting inflammasome activation.…”

Section: Discussionmentioning

confidence: 99%

Aerobic exercise reverses the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin to alleviate post-stroke depression

Tang¹,

Liao²,

Liu³

et al. 2022

Ann Transl Med

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Background: Post-stroke depression (PSD) is one of the most common and serious sequelae of stroke.The pathogenesis of PSD involves both psychosocial and biological mechanisms, and aerobic exercise is a potential therapeutic target. We conducted an in-depth exploration of the protective mechanisms of aerobic exercise in a PSD mouse model. Methods:In this study, C57BL/6 mice were used as the research objects, and a PSD mouse model was established by combining middle cerebral artery occlusion and chronic unpredictable mild stimulation.Real-time quantitative polymerase chain reaction, enzyme-linked immunosorbent assays, adeno-associated virus microinjection technology, co-immunoprecipitation, fluorescence in-situ hybridization, and western blotting were performed. A moderate-load treadmill exercise was used for aerobic exercise intervention. The moderate-intensity aerobic exercise training method adopted 0 slopes and treadmill adaptation training for 5 days. We verified the effects of aerobic exercise on the nuclear factor kappa B (NF-κB)/nucleotide-binding oligomerization domain--like receptor protein 3 (NLRP3) inflammasome/5-hydroxytryptamine (5-HT) pathway.Results: Aerobic exercise effectively alleviated the neurological damage caused by PSD (P<0.01). The results from the PSD mouse model in vivo were consistent with those of the cell experiments. Moreover, overexpression of irisin improves depression-like behavior in PSD mice. We confirmed that aerobic exercise is involved in PSD through 5-HT, which inhibits NF-κB/NLRP3 inflammasome initiation through irisin and alleviates mitochondrial damage under stress by reducing calcium overload, thereby inhibiting NLRP3 inflammasome activation.Conclusions: Aerobic exercise reversed the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin expression to alleviate PSD.

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Section: Discussionmentioning

confidence: 99%

Aerobic exercise reverses the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin to alleviate post-stroke depression

Tang¹,

Liao²,

Liu³

et al. 2022

Ann Transl Med

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“…Based on the different characteristics of depression, psychologists had developed many forms of treatments that aimed to reduce depressive symptoms. Cognitive Behavioural Therapy (CBT) is one of the most popular interventions used to deal with depression and had been proven to be effective in many studies in not just reducing depressive symptoms but also preventing recurrence [2]. CBT is a form of psychotherapy that involves asking patients to attend averagely 8-10 hour-long sessions.…”

Section: Introductionmentioning

confidence: 99%

“…During the sessions, a counsellor will help the patient identify negative thoughts that led to the depressive symptoms, assist the patient to see if there is any evidence supporting the negative thought and teach the patient to replace it with a more positive one [3]. Studies had been carried out to investigate the effectiveness of CBT for depression, but often only focused on limited conditions such as only comparing the delivering forms of CBT but ignoring the severity of depression or vice versa [2,4]. Other studies had compared the effectiveness between different kinds of treatments including CBT but did not consider within CBT conditions such as different forms of CBT may vary in its effectiveness [5].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the effectiveness of cognitive behavioural therapy in treating major depressive disorder with comparison to that of antidepressant and other forms of psychotherapy

Guo

2023

International Conference on Modern Medicine and Global Health (ICMMGH 2023)

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“…According to the severity of symptoms, depression can be clinically classified as mild, moderate, or severe. Mild to moderate depression (MMD), including less than five symptoms of depression ( Liu et al, 2020 ), occurs more frequently than severe depression in clinical practice ( Meng et al, 2021 ). Given its high incidence, it is important to explore the cognitive and neurobiological factors that relate to the onset, maintenance, and recurrence of MMD.…”

Section: Introductionmentioning

confidence: 99%

Neuroanatomical Correlates of Mild-to-Moderate Depression: Memory Ability Mediates the Association Between Gray Matter Volume and Antidepressant Treatment Outcome

Wang

et al. 2022

Front. Neurosci.

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Mild-to-moderate depression (MMD) is frequently encountered in clinical practice. Investigating the brain mechanism and its relationship with symptoms in patients with MMD can help us understand the occurrence and development of depression, thus optimizing the prevention and treatment of depression. Shugan Jieyu capsule (SG), a traditional Chinese medicine, is commonly used to ameliorate emotional and cognitive symptoms induced by patients with MMD. Combining clinical assessments and magnetic resonance imaging (MRI), we obtained the emotional and cognitive status of MMD patients and also explored the structural and functional alterations in MMD patients after SG treatments. Structural MRI demonstrated that the gray matter volumes of the left thalamus, right thalamus, and right amygdala in MMD patients were significantly smaller than in healthy controls, and the right amygdala volume was negatively related to depression symptoms in MMD patients. Resting-state functional MRI data demonstrated that MMD patients exhibited decreased temporal coupling between the right amygdala and nucleus accumbens, which was further associated with the severity of depression. Furthermore, right amygdala volume at baseline served as a significant predictor to identify the treatment outcome after 8 weeks of SG treatment in the patients’ group, and importantly, the memory ability mediated the relationship from right amygdala volume to the treatment outcome. These data revealed the structural and functional deficits in the right amygdala, which were highly correlated with the symptoms of depression and its cognitive ability, likely predicting treatment outcome. Therefore, this study strengthened our understanding of the pathogenesis of MMD, which is hoped that it will contribute to tailoring a personalized method for treating the patients.

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Cognitive behavioral therapy for patients with mild to moderate depression: Treatment effects and neural mechanisms

Cited by 12 publications

References 67 publications

Aerobic exercise reverses the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin to alleviate post-stroke depression

Aerobic exercise reverses the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin to alleviate post-stroke depression

Analysis of the effectiveness of cognitive behavioural therapy in treating major depressive disorder with comparison to that of antidepressant and other forms of psychotherapy

Neuroanatomical Correlates of Mild-to-Moderate Depression: Memory Ability Mediates the Association Between Gray Matter Volume and Antidepressant Treatment Outcome

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