Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele

Takeuchi, Hikaru; Tomita, Hiroaki; Taki, Yasuyuki; Kikuchi, Yoku; Ono, Chiaki; Yu, Zhiqian; Sekiguchi, Atsushi; Nouchi, Rui; Kotozaki, Yuka; Nakagawa, Seishu; Miyauchi, Carlos Makoto; Iizuka, Kunio; Yokoyama, Ryoichi; Shinada, Takamitsu; Yamamoto, Yuki; Hanawa, Sugiko; Araki, Tsuyoshi; Hashizume, Hiroshi; Kunitoki, Keiko; Sassa, Yuko; Kawashima, Ryuta

doi:10.1016/j.neuroimage.2015.01.053

Cited by 31 publications

(43 citation statements)

References 99 publications

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“…It was found in course of studying aggressive and antisocial behavior that the*7R repeats were more often encountered in people convicted for violent crimes (Cherepkova et al, 2016), especially the ones, who experienced stress factors in their childhood (Schlomer et al, 2015). At the same time, it was shown for the Russian sample of inmates that the *5R allele carriers also demonstrated high aggression levels similar to those of the*7R allele carriers (Cherepkova et al, 2015), which agrees with the data on identical functional changes in the DRD4 receptor with 5 or 7 repeats (Takeuchi et al, 2015).…”

Section: Molecular-genetic Markers Of Predisposition Towards Aggressisupporting

confidence: 66%

Recent advances in genetics of aggressive behavior

Davydova¹,

Litvinov²,

Enikeeva³

et al. 2018

Vestn. VOGiS

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One of the most important problems of modern neurobiology and medicine is an understanding of the mechanisms of normal and pathological behavior of a person. Aggressive behavior is an integral part of the human psyche. However, environmental risk factors, mental illness and somatic diseases can lead to increased aggression to be the biological basis of antisocial behavior in a human society. An important role in development of aggressive behavior belongs to the hereditary factors that may be linked to abnormal functioning of neurotransmitter systems in the brain yet the underlying genetic mechanisms remain unclear, which is due to a large number of single nucleotide polymorphisms, insertions and deletions in the structure of genes that encode the components of the neurotransmitter systems. The most studied candidate genes for aggressive behavior are serotonergic (TPH1, TPH2, HTR2A, SLC6A4) and dopaminergic (DRD4, SLC6A3) system genes, as well as the serotonin or catecholamine metabolizing enzyme genes (COMT, MAOA). In addition, there is evidence that the hypothalamic-pituitary system genes (OXT, OXTR, AVPR1A, AVPR1B), the sex hormone receptors genes (ER1, AR), neurotrophin (BDNF) and neuronal apoptosis genes (CASP3, BAX) may also be involved in development of aggressive behavior. The results of Genome-Wide Association Studies (GWAS) have demonstrated that FYN, LRRTM4, NTM, CDH13, DYRK1A and other genes are involved in regulation of aggressive behavior. These and other evidence suggest that genetic predisposition to aggressive behavior may be a very complex process.

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Section: Molecular-genetic Markers Of Predisposition Towards Aggressisupporting

confidence: 66%

Recent advances in genetics of aggressive behavior

Davydova¹,

Litvinov²,

Enikeeva³

et al. 2018

Vestn. VOGiS

View full text Add to dashboard Cite

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“…Treffinger [1985] also warned that separate interpretations of TTCT subscores should be avoided. However, some studies have found specific effects of each subscale, especially originality [Takeuchi et al, 2015d]. Thus, we believe that using only the total score serves the purpose of this study.…”

Section: Divergent Thinking Assessmentmentioning

confidence: 96%

“…Thus, we believe that using only the total score serves the purpose of this study. However, some studies have found specific effects of each subscale, especially originality [Takeuchi et al, 2015d]. Thus, with the aforementioned limitation in mind, we also performed separate but identical analyses in which the total score on the S-A creativity test was replaced with each of the subscale scores.…”

Section: Divergent Thinking Assessmentmentioning

confidence: 99%

Creative females have larger white matter structures: Evidence from a large sample study

Takeuchi

Taki

Nouchi

et al. 2016

Human Brain Mapping

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The importance of brain connectivity for creativity has been theoretically suggested and empirically demonstrated. Studies have shown sex differences in creativity measured by divergent thinking (CMDT) as well as sex differences in the structural correlates of CMDT. However, the relationships between regional white matter volume (rWMV) and CMDT and associated sex differences have never been directly investigated. In addition, structural studies have shown poor replicability and inaccuracy of multiple comparisons over the whole brain. To address these issues, we used the data from a large sample of healthy young adults (776 males and 560 females; mean age: 20.8 years, SD = 0.8). We investigated the relationship between CMDT and WMV using the newest version of voxel-based morphometry (VBM). We corrected for multiple comparisons over whole brain using the permutation-based method, which is known to be quite accurate and robust. Significant positive correlations between rWMV and CMDT scores were observed in widespread areas below the neocortex specifically in females. These associations with CMDT were not observed in analyses of fractional anisotropy using diffusion tensor imaging. Using rigorous methods, our findings further supported the importance of brain connectivity for creativity as well as its female-specific association. Hum Brain Mapp 38:414-430, 2017. © 2016 Wiley Periodicals, Inc.

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“…The following neuropsychological tests were performed according to the methods described in a previous study (Takeuchi et al 2015 fMRI Tasks fMRI was used to map brain activity during cognitive tasks. The N-back task is a typical task for fMRI studies with conditions of 0-back (simple cognitive processes) and 2-back (working memory).…”

Section: Psychological Measuresmentioning

confidence: 99%

“…The methods for MR image acquisition were described in our previous study (Takeuchi et al 2015) and reproduced below. All MRI data acquisition was performed using a 3-T Philips Achieva scanner.…”

Section: Image Acquisitionmentioning

confidence: 99%

A Common CACNA1C Gene Risk Variant has Sex-Dependent Effects on Behavioral Traits and Brain Functional Activity

et al. 2018

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Genome-wide association studies have suggested that allelic variations in the CACNA1C gene confer susceptibility to schizophrenia and bipolar disorder only in women. Here we investigated the sex-specific effects of the CACNA1C variant rs1024582 on psychiatry-related traits, brain activity during tasks and rest, and brain volume in 1207 normal male and female subjects. After correcting for multiple comparisons, there were significant interaction effects between sex and the minor allele of this polymorphism on the hostile behavior subscale scores of the Coronary-Prone Type Scale mediated by higher scores in female carriers of the minor allele. Imaging analyses revealed significant interaction effects between sex and the minor allele on fractional amplitude of low-frequency fluctuations in the right dorsolateral prefrontal cortex and on brain activity during the 2-back task in areas of the right posterior cingulate cortex, right thalamus, and right hippocampus, which were all mediated by reduced activity in female carriers of the minor allele. Our results demonstrated that the rs1024582 risk variant of CACNA1C is associated with reduced activity in the frontolimbic regions at rest and during a working memory task as well as with greater hostility in females in the healthy population.

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Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele

Cited by 31 publications

References 99 publications

Recent advances in genetics of aggressive behavior

Recent advances in genetics of aggressive behavior

Creative females have larger white matter structures: Evidence from a large sample study

A Common CACNA1C Gene Risk Variant has Sex-Dependent Effects on Behavioral Traits and Brain Functional Activity

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