volume 24, issue s2, P153-159 2011
DOI: 10.3233/jad-2011-110239
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Gabrielle B. Britton, K.S.J. Rao

Abstract: Despite the profound burden of Alzheimer's disease (AD) on public health, research to understand its underlying pathology has not yet produced new therapeutic approaches to improve symptoms or halt disease progression. AD is characterized by early cognitive deficits, particularly in short-term memory, followed by a gradual decline in other cognitive functions. Functional imaging studies indicate that hippocampal and medial temporal lobe cortices are the sites of early pathology underlying the initial memory im…

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