Cofilin, an intracellular marker for HIV‐associated CD4 T‐cell motility dysregulation, shed light on the mechanisms of incomplete immune reconstitution in the patients with HIV

Syed, Fahim; Yu, Qigui

doi:10.1002/jmv.25577

Cited by 61 publications

(93 citation statements)

References 10 publications

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“…Epidemiologic measurements have been explored to identify the dynamics of disease regarding the spread risk and the effect of human mobility [3][4][5][6][7][8][9][10]. Besides, since the mobility restrictions are considered as a critical factor to prevent the disease spread, studies have assessed its impact [11][12][13][14][15][16]. Non-pharmaceutical observations are also proven to be effective data sources to have an integrated perspective.…”

Section: Introductionmentioning

confidence: 99%

Human mobility trends during the early stage of the COVID-19 pandemic in the United States

et al. 2020

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In March of this year, COVID-19 was declared a pandemic, and it continues to threaten public health. This global health crisis imposes limitations on daily movements, which have deteriorated every sector in our society. Understanding public reactions to the virus and the non-pharmaceutical interventions should be of great help to fight COVID-19 in a strategic way. We aim to provide tangible evidence of the human mobility trends by comparing the day-by-day variations across the U.S. from January 2020 to early April 2020. Large-scale public mobility at an aggregated level is observed by leveraging mobile device location data and the measures related to social distancing. Our study captures spatial and temporal heterogeneity as well as the sociodemographic variations and teleworking trends regarding the pandemic propagation and the non-pharmaceutical mobility interventions. All metrics adapted capture decreased public movements after the national emergency declaration. The population staying home has increased in all states before the stay-at-home mandates implemented and becomes more stable after the order with a smaller range of fluctuation. The public had been taking active responses, voluntarily staying home more, to the in-state confirmed cases while the stay-at-home orders stabilize the variations. As the estimated teleworking rates also continue to incline throughout the study period, the teleworking trend can be another driving factor for the growing stay-at-home population. We confirm that there exists overall mobility heterogeneity between the income or population density groups. The study suggests that public mobility trends are in line with the government message urging to stay home. We anticipate our data-driven analysis offers integrated perspectives and serves as evidence to raise public awareness and, consequently, reinforce the importance of social distancing while assisting policymakers.

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Section: Introductionmentioning

confidence: 99%

Human mobility trends during the early stage of the COVID-19 pandemic in the United States

et al. 2020

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“…Priya and Shanker ( Priya & Shanker, 2020 ) have observed that the coevolutionary forces can increase the fitness of spike glycoprotein against ACE2 and increase the infectivity of SARS-CoV-2. According to Uddin et al ( Uddin et al, 2020 ) antigenic epitopes of SARS-CoV-2 and SARS-CoV have highest level of similarities among them.SARS-CoV-2 is the seventh coronavirus to infect humans but the first HCoV which pandemic potential ( Seyran et al, 2020 ). (Accession no: NC _045512) is the first SARS-CoV-2 sample SARS-CoV-2 sequence from Wuhan, and it is from clade’O′(Others) ( Mercatelli & Giorgi, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Clade GR and clade GH isolates of SARS-CoV-2 in Asia show highest amount of SNPs

Sengupta

Hassan²,

Choudhury

2021

Infection, Genetics and Evolution

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“…Similar to CRF60_BC, the subtype C parental strain of CRF108_BC is phylogenetically related to the subtype C strain circulating in Brazil. However, the recombination event giving rise to CRF108_BC could have occurred either in Brazil, where both B and C subtypes co-circulate at high proportions in some areas [ 42 , 43 ] or in Spain, since we could not track the ancestry of the parental subtype B strain to any country. A Spanish origin of CRF108_BC would be supported by an inferred Spanish tMRCA in the city of Vitoria, Basque Country, Northern Spain, around 2000.…”

Section: Discussionmentioning

confidence: 99%

Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain

Cañada

Delgado

Gil

et al. 2021

Viruses

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The extraordinary genetic variability of human immunodeficiency virus type 1 (HIV-1) group M has led to the identification of 10 subtypes, 102 circulating recombinant forms (CRFs) and numerous unique recombinant forms. Among CRFs, 11 derived from subtypes B and C have been identified in China, Brazil, and Italy. Here we identify a new HIV-1 CRF_BC in Northern Spain. Originally, a phylogenetic cluster of 15 viruses of subtype C in protease-reverse transcriptase was identified in an HIV-1 molecular surveillance study in Spain, most of them from individuals from the Basque Country and heterosexually transmitted. Analyses of near full-length genome sequences from six viruses from three cities revealed that they were BC recombinant with coincident mosaic structures different from known CRFs. This allowed the definition of a new HIV-1 CRF designated CRF108_BC, whose genome is predominantly of subtype C, with four short subtype B fragments. Phylogenetic analyses with database sequences supported a Brazilian ancestry of the parental subtype C strain. Coalescent Bayesian analyses estimated the most recent common ancestor of CRF108_BC in the city of Vitoria, Basque Country, around 2000. CRF108_BC is the first CRF_BC identified in Spain and the second in Europe, after CRF60_BC, both phylogenetically related to Brazilian subtype C strains.

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Cofilin, an intracellular marker for HIV‐associated CD4 T‐cell motility dysregulation, shed light on the mechanisms of incomplete immune reconstitution in the patients with HIV

Cited by 61 publications

References 10 publications

Human mobility trends during the early stage of the COVID-19 pandemic in the United States

Human mobility trends during the early stage of the COVID-19 pandemic in the United States

Clade GR and clade GH isolates of SARS-CoV-2 in Asia show highest amount of SNPs

Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain

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