Coffee Consumption and Type 2 Diabetes Mellitus

Schaefer, Benjamin M.

doi:10.7326/0003-4819-141-4-200408170-00016

Cited by 7 publications

(4 citation statements)

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“…These results have been questioned, since there is a number of potential confounders 6 , 7 and some conflicting epidemiological lines of evidence. 8 , 9 However, the obvious discrepancy between the acute deterioration of glucose tolerance and the long-term diabetes-preventive effect became at least partially understandable by the observation that the glucose increase during the oral glucose tolerance test was lower in habitual coffee drinkers than in non-drinkers.…”

Section: Introductionmentioning

confidence: 99%

Effect of chronic coffee consumption on weight gain and glycaemia in a mouse model of obesity and type 2 diabetes

et al. 2014

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Objective:Epidemiological evidence shows that chronic coffee consumption in humans is correlated with a lower incidence of type 2 diabetes mellitus. For the experimental exploration of the underlying mechanisms, this effect needs to be replicated in an animal model of type 2 diabetes with a short lifespan.Design:Male C57BL/6 mice consumed regular coffee or water ad libitum and the development of obesity and diabetes caused by high-fat diet (55% lipids, HFD) was observed from week 10 on for 35 weeks in comparison with mice feeding on a defined normal diet (9% lipids, ND).Results:The massive weight gain in HFD mice was dose-dependently retarded (P=0.034), the moderate weight gain in ND mice was abolished (P<0.001) by coffee consumption, probably because of a lower feeding efficiency. The consumption of fluid (water or coffee) was significantly diminished by HFD (P<0.001), resulting in a higher coffee exposure of ND mice. On week 21 intraperitoneal glucose tolerance tests (IPGTT) showed a dose-dependent faster decline of elevated glucose levels in coffee-consuming HFD mice (P=0.016), but not in ND mice. Remarkably, a spontaneous decrease in non-fasting glycaemia occurred after week 21 in all treatment groups (P<0.001). On week 39 the IPGTT showed diminished peak of glucose levels in coffee-consuming HFD mice (P<0.05). HFD mice were hyperinsulinaemic and had significantly (P<0.001) enlarged islets. Coffee consumption did not affect islet size or parameters of beta-cell apoptosis, proliferation and insulin granule content.Conclusion:Coffee consumption retarded weight gain and improved glucose tolerance in a mouse model of type 2 diabetes and corresponding controls. This gives rise to the expectation that further insight into the mechanism of the diabetes-preventive effect of coffee consumption in humans may be gained by this approach.

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Section: Introductionmentioning

confidence: 99%

Effect of chronic coffee consumption on weight gain and glycaemia in a mouse model of obesity and type 2 diabetes

et al. 2014

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“…Coffee is among the most widely consumed beverages in the world. 5 Knowledge on both the positive and negative health effects of coffee is important to allow individuals to make informed choices regarding coffee consumption. In addition, data on the health effects of different coffee constituents and of different types of coffee can contribute to disease prevention.…”

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confidence: 99%

Coffee Consumption and Risk of Type 2 Diabetes

Dam¹,

Hu²

2005

JAMA

607

371

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Context Emerging epidemiological evidence suggests that higher coffee consumption may reduce the risk of type 2 diabetes.Objective To examine the association between habitual coffee consumption and risk of type 2 diabetes and related outcomes. Data Sources and Study SelectionWe searched MEDLINE through January 2005 and examined the reference lists of the retrieved articles. Because this review focuses on studies of habitual coffee consumption and risk of type 2 diabetes, we excluded studies of type 1 diabetes, animal studies, and studies of short-term exposure to coffee or caffeine, leaving 15 epidemiological studies (cohort or cross-sectional).Data Extraction Information on study design, participant characteristics, measurement of coffee consumption and outcomes, adjustment for potential confounders, and estimates of associations was abstracted independently by 2 investigators. Data SynthesisWe identified 9 cohort studies of coffee consumption and risk of type 2 diabetes, including 193 473 participants and 8394 incident cases of type 2 diabetes, and calculated summary relative risks (RRs) using a random-effects model. The RR of type 2 diabetes was 0.65 (95% confidence interval [CI], 0.54-0.78) for the highest (Ն6 or Ն7 cups per day) and 0.72 (95% CI, 0.62-0.83) for the second highest (4-6 cups per day) category of coffee consumption compared with the lowest consumption category (0 or Յ2 cups per day). These associations did not differ substantially by sex, obesity, or region (United States and Europe). In the cross-sectional studies conducted in northern Europe, southern Europe, and Japan, higher coffee consumption was consistently associated with a lower prevalence of newly detected hyperglycemia, particularly postprandial hyperglycemia.Conclusions This systematic review supports the hypothesis that habitual coffee consumption is associated with a substantially lower risk of type 2 diabetes. Longer-term intervention studies of coffee consumption and glucose metabolism are warranted to examine the mechanisms underlying the relationship between coffee consumption and type 2 diabetes.

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“…Coffee is one of the most widely consumed beverages (Schaefer, 2004) and various effects on human health have been postulated to coffee consumption. Recent prospective cohort studies showed that coffee consumption may lower the risk of DM (Tuomilehto et al, 2004;van Dam et al, 2004van Dam et al, , 2006Hu et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Coffee consumption is not related to the metabolic syndrome at the age of 36 years: the Amsterdam Growth and Health Longitudinal Study

et al. 2008

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Background/Objectives: Coffee consumption has been postulated to decrease the risk of diabetes mellitus type II. The longterm effects of coffee consumption on the metabolic syndrome (MS) and its components are unknown. This study investigated the relationship of long-term coffee consumption between the age of 27 and 36 years with the prevalence of the MS at the age of 36 years. Subject/Methods: Data on coffee consumption and the MS components were derived from a healthy sample of 174 men and 194 women followed up from the age of 27 years onwards. Data analysis was performed with the use of generalized estimating equations and regression analysis. Results: At the age of 36 years, the prevalence of the MS was 10.1%. The growth of coffee consumption did not differ significantly between subjects with or without the MS or its components. Regression analyses showed that one cup day À1 higher coffee consumption was related to 0.11 mm Hg lower mean arterial blood pressure (P ¼ 0.03), 0.02 mg 100 ml À1 higher triglyceride level (P ¼ 0.57), 0.04 mg 100 ml À1 higher high-density lipoprotein cholesterol level (P ¼ 0.35), 0.09% higher HbA 1c (P ¼ 0.12) and 0.02 cm larger waist circumference (P ¼ 0.57). After adjustment for physical activity, energy intake, smoking behaviour and alcohol consumption, none of the relationships between coffee consumption and the MS or its components was significant. Conclusions: Coffee consumption is not associated with the MS or its components in a healthy sample followed up for 9 years.

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Coffee Consumption and Type 2 Diabetes Mellitus

Cited by 7 publications

References 0 publications

Effect of chronic coffee consumption on weight gain and glycaemia in a mouse model of obesity and type 2 diabetes

Effect of chronic coffee consumption on weight gain and glycaemia in a mouse model of obesity and type 2 diabetes

Coffee Consumption and Risk of Type 2 Diabetes

Coffee consumption is not related to the metabolic syndrome at the age of 36 years: the Amsterdam Growth and Health Longitudinal Study

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