Coexisting childhood pemphigus foliaceus and Graves' disease

Abstract

We report herein the concurrent appearance of childhood pemphigus foliaceus and Graves' disease in a 14-year-old girl who was initially seen with crusted and hyperpigmented plaques on her chest, back, abdomen, and legs. The diagnosis of pemphigus foliaceus was confirmed by biopsy and immunofluorescent microscopic studies while the diagnosis of Graves' disease was based on clinical and laboratory findings. The coexistence of these two immune-mediated diseases in a single patient suggest that some persons may bear a unique predisposition to the development of two or more autoimmune-type disorders that may affect diverse organ systems.

Sporadic Pemphigus Foliaceus in a 3-Year-Old Vietnamese Girl: A Case Report and Literature Review

“…Previous studies have shown that PF is associated with myasthenia gravis and thymoma in adults. Although this connection was not observed in pediatric patients, concurrent occurrences of PF and Graves' disease have been reported in two juvenile cases [10,26]. In addition, other autoimmune diseases including dermatomyositis [18] and neuromyelitis optica [22] have also been reported to be possible comorbidities.…”

Juvenile pemphigus foliaceus

“…12 Adult PF has been reported to be associated with other autoimmune disorders 13,14 and drugs, 15 but Graves' disease is the only condition reported to coexist with childhood PF. 9 The clinical manifestations of adult and juvenile PF are similar. The onset is often slow, with crusting, yellowish, scaling lesions starting on the face and scalp, as in our case, 8 which can mimic impetigo and seborrhoeic dermatitis; unlike PV, the oral mucosa is rarely involved.…”

“…PF, the less severe form of pemphigus, may be treated simply with topical steroids or low-dose corticosteroids; 7 the more generalized form of PF has been treated with high-dose corticosteroids. 9,25 However, Basset et al 26 reported satisfactory results with dapsone as initial therapy. We also achieved fast remission when we added dapsone to low-dose corticosteroids.…”

Dual Diagnosis of Pemphigus and Pemphigoid

“…Several other autoimmune diseases have also been reported in patients with autoimmune mucocutaneous blistering diseases [37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79]. The simultaneous presence of two systemic autoimmune diseases in the same patient has been reported in several studies [80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101].…”