Coexistent psoriasis and bullous pemphigoid: a report of six cases

Abstract

Vesicles and bullae developed in six patients with psoriasis while they were undergoing therapy for their psoriasis. Skin biopsy specimens were taken from their lesions and studied for regular histopathologic findings and direct immunofluorescence. These studies confirmed that they had coexistent psoriasis and bullous pemphigoid. A review of the therapy that the patients were given incriminates anthralin, crude coal tar, ultraviolet light, and salicylic acid in the possible cause of the development of their bullous pemphigoid lesions.

A biological approach in a patient with psoriasis and bullous pemphigoid associated with losartan therapy

“…Although BP recurred when the patient was not on losartan, we suggest that the drug may have merely precipitated the BP, which otherwise might have developed years later; this is highly probable in a patient with severe psoriasis. Coexistence of psoriasis and BP has been reported previously, 3 and psoriasis usually precedes the appearance of pemphigoid, suggesting that previous treatments or common immunogenetic mechanisms might be involved. Our patient was treated in the past with UVB, and phototherapy has been implicated in the appearance of BP 2 .…”

Analysis of current data on the use of methotrexate in the treatment of pemphigus and pemphigoid

“…The occurrence of psoriasis and bullous pemphigoid in the same patient has been reported in a case‐controlled study and multiple case reports 27–30 . In such unusual cases MTX would be the ideal agent to control both diseases.…”

Adalimumab induced exacerbation of psoriasis in patients with combined pemphigus: A case report

“…Psoriasis is a chronic immune-related skin disease, and plaque psoriasis is the most common type with various comorbidities. In 1978, Koerber et al first reported some blistering diseases associated with psoriasis, [5] with the most common being bullous pemphigoid, and there are fewer reports of pemphigus foliaceus associated with it. [6] Studies have shown that the likelihood of psoriasis patients developing new-onset pemphigus foliaceus is more than 3 times that of the control group.…”