Coexistence of Kimura's disease and lichen amyloidosus in three patients

Abstract

Three patients had Kimura's disease with multiple asymptomatic subcutaneous tumors of 11 to 20 years' duration on the head, soft palate, elbow, or inguinal regions associated with enlarged regional lymph nodes. In each patient, lichen amyloidosus had also developed on the extensor surfaces of the extremities during the past 12 to 20 years. Blood eosinophilia (26% to 75%) was present in all cases. The possible pathogenetic relationship between Kimura's disease and primary localized cutaneous amyloidosis is discussed.

Elevated Serum Levels of TARC/CCL17, Eotaxin-3/CCL26 and VEGF in a Patient with Kimura’s Disease and Prurigo-like Eruption

“…Several authors have reported cases of KD preceded by eczematoid lesions, such as pruritic papules, in patients with past histories of atopy (2, 3), and lichen amyloidosis (11). Our patient also had widespread prurigo-like eruption, which preceded the development of KD by several years.…”

Primary cutaneous amyloidosis associated with autoimmune hepatitis-primary biliary cirrhosis overlap syndrome and Sjögren syndrome

“…[ 15 ] Associations described so far include primary biliary cirrhosis, systemic sclerosis, scleroderma, Kimura disease, and SS. [ 4 – 6 , 16 , 17 ] A pathogenic relationship between PCA and keratinocyte apoptosis has been hypothesized. [ 18 ] Kamada et al [ 19 ] reported that bilirubin caused damage to cultured keratinocytes, which may lead to cutaneous amyloidosis.…”

Primary localized cutaneous amyloidosis: a sign of immune dysregulation?

“…An increasing number of reports in the literature link PLCA to various immune disorders. Associations described so far include: systemic sclerosis, 4–7 CREST syndrome, 8 rheumatoid arthritis, 9 systemic lupus erythematosus, 9,10 primary biliary cirrhosis, 11 autoimmune cholangitis, 12 Kimura's disease, 13,14 ankylosing spondylitis and autoimmune thyroiditis, 15 the last two occurring in the same patient. Except for the patients with systemic sclerosis and Kimura's disease, in whom PLCA followed the classical pattern of distribution, most of these patients had an atypical distribution 10 and/or extensive clinical presentation.…”