Coexistence of asthma and polycystic ovary syndrome: A concise review

Zierau, Louise; Gade, Elisabeth Juul; Lindenberg, Svend; Backer, Vibeke; Thomsen, Simon Francis

doi:10.1016/j.rmed.2016.08.025

Cited by 17 publications

(17 citation statements)

References 48 publications

(43 reference statements)

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“…Our results confirm the literature that has reported that PCOS is independently associated with asthma [20,23,39]. The relationship between asthma and PCOS is likely to be multifactorial, but there are mechanisms proposed that could explain the association.…”

Section: Discussionsupporting

confidence: 91%

The Association between Dietary Intake, Asthma, and PCOS in Women from the Australian Longitudinal Study on Women’s Health

Grieger

Hodge

Mishra

et al. 2020

JCM

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Dietary intake potentially modifies the prevalence or severity of asthma. The prevalence of asthma is higher in women with polycystic ovary syndrome (PCOS); it is not known if diet confounds or modifies the association between asthma and PCOS. The aims of this study were: (i) To determine if the association of PCOS and asthma is independent of dietary pattern and (ii) to determine if dietary pattern modifies the association between PCOS and asthma. Women in this study were from the Australian Longitudinal Study on Women’s Health (ALSWH) cohort born between 1973 to 1978 and aged 18 to 23 years (n = 7382). Logistic regression was used to assess the association between PCOS and asthma, adjusting for the following: (i) Potential confounders identified a priori and (ii) dietary patterns (z-score) identified by principle component analysis. In the adjusted analysis, women with PCOS were more likely to have asthma than the women without PCOS (OR 1.35 and 95% CI, 1.02 and 1.78). This relationship was not altered by further adjustment for dietary patterns (non-core food, meats and takeaway, or Mediterranean-style pattern). In the interaction analysis, only the women consuming less than the median intake of non-core foods (i.e., lower intake of discretionary or unhealthy foods) and with PCOS were more likely to have asthma (OR 1.91 and 95% CI, 1.29 and 2.82). Dietary intake did not confound the relationship between PCOS and asthma. Other mechanistic pathways are likely responsible for the asthma and PCOS association, and further studies assessing factors such as oral contraceptive use and sex steroid hormones warrant investigation.

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Section: Discussionsupporting

confidence: 91%

The Association between Dietary Intake, Asthma, and PCOS in Women from the Australian Longitudinal Study on Women’s Health

Grieger

Hodge

Mishra

et al. 2020

JCM

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“…obese women or women with a metabolic syndrome have an increased TTP [30, 31]. Metabolic syndrome is a part of polycystic ovary syndrome (PCOS), and Zieraua et al , in meta-analyses, confirmed that asthma may be associated with PCOS, and women with PCOS have a more severe type of asthma [32]. Also, an interesting observation is the fact that a greater number of females undergoing in vitro fertility (IVF) treatment were using anti-asthmatic drugs [33].…”

Section: Time To Pregnancy (Ttp)mentioning

confidence: 99%

Impact of allergic diseases on fertility

Wasilewska¹,

Małgorzewicz²

2019

pdia

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The incidence of allergic diseases has been increasing in recent decades, and currently, nearly 30% of the European population suffer from some type of allergy. Also, an increasing number of people are suffering from infertility. Both diseases are related to the hormonal and immune systems, which prompts the question as to whether there is a causal relationship between allergic disorders and the reproductive system. The purpose of this review is to evaluate whether there is a link between allergic diseases and infertility, using the available literature.

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“…Currently, the incidence of asthma among PCOS patients still remains controversial. In recent years, more than a dozen articles from different countries have reported the prevalence of asthma in PCOS patients [26][27][28] . However, due to the differences in race, population, patient age, BMI and other factors, the results were not consistent.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Asthma in Polycystic Ovary Syndrome Women: A Meta-analysis

Sun¹,

Li²,

Jiao³

et al. 2020

Preprint

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Background: A few publications have reported the prevalence of asthma in polycystic ovary syndrome (PCOS) patients. But it remains debatable whether PCOS is an independent risk factor of asthma. Thus we carried out this systematic review and meta-analysis to assess the association between PCOS and asthma.Methods：PubMed, Embase, web of science, Scopus, Cochrane trial register, China National Knowledge Infrastructure (CNKI) and Wanfang Databases were searched for studies published from inception to October 2020. We extracted the data and performed the meta-analysis under the guidance of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We used a random-effects model and calculated the odds ratios (ORs) and 95% confidence intervals (95% CIs).Results：A total of 6 articles concerning 26876 PCOS women and 156143 healthy controls were included. According to the result of the study, PCOS patients have increased risk of asthma (OR=1.75, 95%CI=1.40–2.19, I2=91.2%, P=0.000, random-effects model). When stratified by region, diagnostic cirteria for asthma and study design, the results did not show significant difference.Conclusions： PCOS leads to higher asthma risk, and this association is independent to region, diagnostic cirteria for asthma and study design.

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Coexistence of asthma and polycystic ovary syndrome: A concise review

Cited by 17 publications

References 48 publications

The Association between Dietary Intake, Asthma, and PCOS in Women from the Australian Longitudinal Study on Women’s Health

The Association between Dietary Intake, Asthma, and PCOS in Women from the Australian Longitudinal Study on Women’s Health

Impact of allergic diseases on fertility

Prevalence of Asthma in Polycystic Ovary Syndrome Women: A Meta-analysis

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