Coexistence of 3 Tumors of Neural Crest Origin

Abstract

Objective: To describe the clinical findings in a patient who developed a neurofibroma, meningioma, and choroidal melanoma. Methods: Clinical and histopathological findings of the case are reviewed and presented. Results: The patient had a right superolateral periorbital neurofibroma, a right sphenoid wing meningioma, and a left choroidal juxtapapillary malignant mela-noma. All 3 tumors are derived from neural crest cells. Conclusions: To our knowledge, this is the first report of a patient with this combination of 3 neural crestderived tumors. This case is most appropriately classified as a complex neurocristopathy, a disorder involving the aberrant and pathological proliferation of multiple tissues derived from neural crest cells.

Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma?

“…Tumor to tumor metastases have been documented;[111314] however, there are only five cases reported concerning melanoma and all these reports emphasized on the existence of melanoma cells in the previously existed intracranial host tumor of different origin, which is different from our case. There were no melanoma cells found in the meningioma even though macroscopic appearance was black, which can mean that either the melanoma invaded intracranially and completely changed into meningioma or the meningioma had already existed when melanoma was diagnosed, but it was too small to be discovered from imaging studies.…”

“…We also performed iron staining to exclude the possibility of recurrence of melanoma, and the result was positive which meant that the black color found during surgery was an old hemorrhage [Figure 2]. There are some reports of occurrence of meningioma as a second tumor due to radiotherapeutic effects;[14] however, our patient did not undergo any radio- or chemotherapy after simple resection of melanoma, thereby excluding radiotherapeutic effect as a risk factor for occurrence of meningioma.…”

Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma?

“…Tumor to tumor metastases have been documented;[111314] however, there are only five cases reported concerning melanoma and all these reports emphasized on the existence of melanoma cells in the previously existed intracranial host tumor of different origin, which is different from our case. There were no melanoma cells found in the meningioma even though macroscopic appearance was black, which can mean that either the melanoma invaded intracranially and completely changed into meningioma or the meningioma had already existed when melanoma was diagnosed, but it was too small to be discovered from imaging studies.…”

“…We also performed iron staining to exclude the possibility of recurrence of melanoma, and the result was positive which meant that the black color found during surgery was an old hemorrhage [Figure 2]. There are some reports of occurrence of meningioma as a second tumor due to radiotherapeutic effects;[14] however, our patient did not undergo any radio- or chemotherapy after simple resection of melanoma, thereby excluding radiotherapeutic effect as a risk factor for occurrence of meningioma.…”

Futility of the autoimmune orthodoxy in multiple sclerosis research

“……”

Melanocytoma of the Left Optic NerveHead and Right Retrobulbar Optic Neuropathy Compressed by a Tuberculum sellae Meningioma

“…They further reported a possible relationship between both lesions rather than a chance occurrence [10]. Warwar et al [11]described the coexistence of three tumors (neurofibroma, meningioma, and uveal malignant melanoma) of neural chest origin in a 64-year-old woman. Limas and Tio [12]reported a 71-year-old man with meningeal melanocytoma.…”

Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma?

“…Tumor to tumor metastases have been documented;[111314] however, there are only five cases reported concerning melanoma and all these reports emphasized on the existence of melanoma cells in the previously existed intracranial host tumor of different origin, which is different from our case. There were no melanoma cells found in the meningioma even though macroscopic appearance was black, which can mean that either the melanoma invaded intracranially and completely changed into meningioma or the meningioma had already existed when melanoma was diagnosed, but it was too small to be discovered from imaging studies.…”

“…We also performed iron staining to exclude the possibility of recurrence of melanoma, and the result was positive which meant that the black color found during surgery was an old hemorrhage [Figure 2]. There are some reports of occurrence of meningioma as a second tumor due to radiotherapeutic effects;[14] however, our patient did not undergo any radio- or chemotherapy after simple resection of melanoma, thereby excluding radiotherapeutic effect as a risk factor for occurrence of meningioma.…”

Futility of the autoimmune orthodoxy in multiple sclerosis research

“……”

Melanocytoma of the Left Optic NerveHead and Right Retrobulbar Optic Neuropathy Compressed by a Tuberculum sellae Meningioma

“…They further reported a possible relationship between both lesions rather than a chance occurrence [10]. Warwar et al [11]described the coexistence of three tumors (neurofibroma, meningioma, and uveal malignant melanoma) of neural chest origin in a 64-year-old woman. Limas and Tio [12]reported a 71-year-old man with meningeal melanocytoma.…”

Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma?

“…Tumor to tumor metastases have been documented;[111314] however, there are only five cases reported concerning melanoma and all these reports emphasized on the existence of melanoma cells in the previously existed intracranial host tumor of different origin, which is different from our case. There were no melanoma cells found in the meningioma even though macroscopic appearance was black, which can mean that either the melanoma invaded intracranially and completely changed into meningioma or the meningioma had already existed when melanoma was diagnosed, but it was too small to be discovered from imaging studies.…”

“…We also performed iron staining to exclude the possibility of recurrence of melanoma, and the result was positive which meant that the black color found during surgery was an old hemorrhage [Figure 2]. There are some reports of occurrence of meningioma as a second tumor due to radiotherapeutic effects;[14] however, our patient did not undergo any radio- or chemotherapy after simple resection of melanoma, thereby excluding radiotherapeutic effect as a risk factor for occurrence of meningioma.…”

Futility of the autoimmune orthodoxy in multiple sclerosis research

“……”

Melanocytoma of the Left Optic NerveHead and Right Retrobulbar Optic Neuropathy Compressed by a Tuberculum sellae Meningioma

“…They further reported a possible relationship between both lesions rather than a chance occurrence [10]. Warwar et al [11]described the coexistence of three tumors (neurofibroma, meningioma, and uveal malignant melanoma) of neural chest origin in a 64-year-old woman. Limas and Tio [12]reported a 71-year-old man with meningeal melanocytoma.…”