Coenzyme Q10: Clinical Applications beyond Cardiovascular Diseases

Abstract

Coenzyme Q10 (CoQ10) is an essential cofactor in oxidative phosphorylation (OXPHOS), present in mitochondria and cell membranes in reduced and oxidized forms. Acting as an energy transfer molecule, it occurs in particularly high levels in the liver, heart, and kidneys. CoQ10 is also an anti-inflammatory and antioxidant agent able to prevent the damage induced by free radicals and the activation of inflammatory signaling pathways. In this context, several studies have shown the possible inverse correlation between the blood levels of CoQ10 and some disease conditions. Interestingly, beyond cardiovascular diseases, CoQ10 is involved also in neuronal and muscular degenerative diseases, in migraine and in cancer; therefore, the supplementation with CoQ10 could represent a viable option to prevent these and in some cases might be used as an adjuvant to conventional treatments. This review is aimed to summarize the clinical applications regarding the use of CoQ10 in migraine, neurodegenerative diseases (including Parkinson and Alzheimer diseases), cancer, or degenerative muscle disorders (such as multiple sclerosis and chronic fatigue syndrome), analyzing its effect on patients’ health and quality of life.

Tumor purity–associated genes influence hepatocellular carcinoma prognosis and tumor microenvironment

“…CoQ10, an energy transfer molecule, occurs in high levels in the liver. As reported by some research, a possible inverse correlation exists between blood CoQ 10 levels and cancer ( 38 ). In the above research, similar to the HK3 gene, the ADCK3 gene also enriched in cancer pathways, cellular communication factor, PI3K-Akt Pathway and virus response.…”

Tumor purity–associated genes influence hepatocellular carcinoma prognosis and tumor microenvironment

“…CoQ10, an energy transfer molecule, occurs in high levels in the liver. As reported by some research, a possible inverse correlation exists between blood CoQ 10 levels and cancer ( 38 ). In the above research, similar to the HK3 gene, the ADCK3 gene also enriched in cancer pathways, cellular communication factor, PI3K-Akt Pathway and virus response.…”

The Effects of Ubiquinol Intake and Sociophysical Training on the Activation of Psychological and Infrared Camera-Measured Body Temperature Physiology and Blood Molecular Markers: A Pilot Study among Healthy Female Older Adults

“…Regarding the potential relationship between CoQ10 supplementation and inflammation, in addition to the correlation we found between sUbiquinol and IL-4, the literature includes reports of relationships with IL-6 and other cytokines [65]. Further study is required to appreciate the potential effects of CoQ10 supplementation on systemic inflammatory state.…”

Prospects of Intravenous Coenzyme Q10 Administration in Emergency Ischemic Conditions

“…Primary CoQ10 deficiency replacement therapy necessitates high doses of CoQ10, with a minimum of 2.4 g/day in adults and not less than 30 mg/kg/day in children over an extended period. The clinical efficacy of CoQ10 has been confirmed in many of clinical studies conducted to date, including recent publications [8,13,[15][16][17][18].…”

Tumor purity–associated genes influence hepatocellular carcinoma prognosis and tumor microenvironment

“…CoQ10, an energy transfer molecule, occurs in high levels in the liver. As reported by some research, a possible inverse correlation exists between blood CoQ 10 levels and cancer ( 38 ). In the above research, similar to the HK3 gene, the ADCK3 gene also enriched in cancer pathways, cellular communication factor, PI3K-Akt Pathway and virus response.…”

The Effects of Ubiquinol Intake and Sociophysical Training on the Activation of Psychological and Infrared Camera-Measured Body Temperature Physiology and Blood Molecular Markers: A Pilot Study among Healthy Female Older Adults

“…Regarding the potential relationship between CoQ10 supplementation and inflammation, in addition to the correlation we found between sUbiquinol and IL-4, the literature includes reports of relationships with IL-6 and other cytokines [65]. Further study is required to appreciate the potential effects of CoQ10 supplementation on systemic inflammatory state.…”

Prospects of Intravenous Coenzyme Q10 Administration in Emergency Ischemic Conditions

“…Primary CoQ10 deficiency replacement therapy necessitates high doses of CoQ10, with a minimum of 2.4 g/day in adults and not less than 30 mg/kg/day in children over an extended period. The clinical efficacy of CoQ10 has been confirmed in many of clinical studies conducted to date, including recent publications [8,13,[15][16][17][18].…”

Tumor purity–associated genes influence hepatocellular carcinoma prognosis and tumor microenvironment

“…CoQ10, an energy transfer molecule, occurs in high levels in the liver. As reported by some research, a possible inverse correlation exists between blood CoQ 10 levels and cancer ( 38 ). In the above research, similar to the HK3 gene, the ADCK3 gene also enriched in cancer pathways, cellular communication factor, PI3K-Akt Pathway and virus response.…”

The Effects of Ubiquinol Intake and Sociophysical Training on the Activation of Psychological and Infrared Camera-Measured Body Temperature Physiology and Blood Molecular Markers: A Pilot Study among Healthy Female Older Adults

“…Regarding the potential relationship between CoQ10 supplementation and inflammation, in addition to the correlation we found between sUbiquinol and IL-4, the literature includes reports of relationships with IL-6 and other cytokines [65]. Further study is required to appreciate the potential effects of CoQ10 supplementation on systemic inflammatory state.…”

Prospects of Intravenous Coenzyme Q10 Administration in Emergency Ischemic Conditions

“…Primary CoQ10 deficiency replacement therapy necessitates high doses of CoQ10, with a minimum of 2.4 g/day in adults and not less than 30 mg/kg/day in children over an extended period. The clinical efficacy of CoQ10 has been confirmed in many of clinical studies conducted to date, including recent publications [8,13,[15][16][17][18].…”