Coenzyme Q10 and Cardiovascular Diseases

Gutiérrez-Mariscal, Francisco M.; Cruz-Ares, Silvia de la; Torres-Peña, José D.; Alcalá‐Díaz, Juan F.; Yubero‐Serrano, Elena M.; López‐Miranda, José

doi:10.3390/antiox10060906

Cited by 47 publications

(44 citation statements)

References 85 publications

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“…The antioxidant properties of CoQ10 also depend on its capacity in recycling other antioxidants such as vitamin C and vitamin E [ 162 ]. CoQ10 deficiency is found in chronic and age-related diseases.…”

Section: Mitochondrial Antioxidant Systemmentioning

confidence: 99%

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Mitochondrial Management of Reactive Oxygen Species

Napolitano

Fasciolo²,

Venditti³

2021

Antioxidants

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Mitochondria in aerobic eukaryotic cells are both the site of energy production and the formation of harmful species, such as radicals and other reactive oxygen species, known as ROS. They contain an efficient antioxidant system, including low-molecular-mass molecules and enzymes that specialize in removing various types of ROS or repairing the oxidative damage of biological molecules. Under normal conditions, ROS production is low, and mitochondria, which are their primary target, are slightly damaged in a similar way to other cellular compartments, since the ROS released by the mitochondria into the cytosol are negligible. As the mitochondrial generation of ROS increases, they can deactivate components of the respiratory chain and enzymes of the Krebs cycle, and mitochondria release a high amount of ROS that damage cellular structures. More recently, the feature of the mitochondrial antioxidant system, which does not specifically deal with intramitochondrial ROS, was discovered. Indeed, the mitochondrial antioxidant system detoxifies exogenous ROS species at the expense of reducing the equivalents generated in mitochondria. Thus, mitochondria are also a sink of ROS. These observations highlight the importance of the mitochondrial antioxidant system, which should be considered in our understanding of ROS-regulated processes. These processes include cell signaling and the progression of metabolic and neurodegenerative disease.

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Section: Mitochondrial Antioxidant Systemmentioning

confidence: 99%

“…CoQ10 deficiency is found in chronic and age-related diseases. For instance, in cardiovascular diseases (CVDs), the reduced bioavailability of CoQ10 is because statins, one of the most common lipid-lowering drugs, inhibits the common pathway shared by CoQ10 endogenous biosynthesis and cholesterol biosynthesis [ 162 ].…”

Section: Mitochondrial Antioxidant Systemmentioning

confidence: 99%

Mitochondrial Management of Reactive Oxygen Species

Napolitano

Fasciolo²,

Venditti³

2021

Antioxidants

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“…Recent research showed that one MetDiet-style meal reduced the expression of proinflammatory molecules [29], the overall systemic inflammatory status [30], and several diseases associated with chronic low-grade inflammation. In adult individuals, a MetDiet intervention led to lower glycoxidative impairment [31] and inflammatory response [32,33]. A meta-analysis including 2300 subjects reported a significant reduction in high-sensitivity C-reactive protein (hs-CRP) (−0.98 mg/L, p < 0.0001), intracellular adhesion molecule-1 (−23.73 ng/mL, p = 0.008), and IL-6 (−0.42 pg/mL, p = 0.008) in individuals assigned to MetDiet, compared with those following a control intervention protocol [34].…”

Section: The Mediterranean Diet: a Healthy Dietary Pattern For People With Sars-cov-2 Infectionmentioning

confidence: 99%

Mediterranean Diet a Potential Strategy against SARS-CoV-2 Infection: A Narrative Review

et al. 2021

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Mediterranean Diet represents the traditional eating habits of populations living around the Mediterranean Sea, and it is associated with a lower risk of overall mortality and cancer incidence and cardiovascular diseases. Severe acute respiratory syndrome coronavirus 2 is a new pandemic, and represents a significant and critical threat to global human health. In this study, we aimed to review the possible effects of Mediterranean Diet against the risk of the coronavirus disease 2019. Several vitamins, minerals, fatty acids, and phytochemicals with their potential anti-COVID-19 activity are presented. Different risk factors may increase or reduce the probability of contracting the disease. Mediterranean Diet has also a positive action on inflammation and immune system and could have a protective effect against severe acute respiratory syndrome coronavirus 2. Further studies are needed to corroborate the benefits of the Mediterranean Diet protective role on infection with SARS-CoV-2.

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“…Coenzyme Q10, also known as ubiquinone, is an organic chemical compound belonging to the group of quinones. Coenzyme Q10 was isolated by Festenstein et al (1955) and Crane et al (1957) [ 12 , 13 ]. Coenzyme Q10 is commonly found in cell membranes, especially mitochondrial membranes, in both reduced (ubiquinol) and oxidized (ubiquinone) forms.…”

Section: Coenzyme Q10—brief Biochemical Overviewmentioning

confidence: 99%

“…This compound enables the basic biochemical reactions that make the life of the organism possible [ 16 ]. Coenzyme Q10 has the ability to transfer electrons ( e− ), therefore its highest concentration occurs in organs characterized by intense energy transformations (concentration: heart (114 μg/g) > kidneys (66.5 μg/g) > liver (55 μg/g) > muscles > brain), because the most important role of this compound is to facilitate the production of adenosine triphosphate (ATP) in mitochondria ( Figure 3 ) [ 13 , 17 ]. Serum coenzyme Q10 concentration is approximately 1 μmol/L [ 18 ].…”

Section: Coenzyme Q10—brief Biochemical Overviewmentioning

confidence: 99%

Heart Failure—Do We Need New Drugs or Have Them Already? A Case of Coenzyme Q10

Filipiak‬

Surma

Romańczyk

2022

JCDD

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Heart failure (HF) is a global epidemic that contributes to the deterioration of quality of life and its shortening in 1–3% of adult people in the world. Pharmacotherapy of HF should rely on highly effective drugs that improve prognosis and prolong life. Currently, the ESC guidelines from 2021 indicate that ACEI, ARNI, BB, and SGLT2 inhibitors are the first-line drugs in HF. It is also worth remembering that the use of coenzyme Q10 brought many benefits in patients with HF. Coenzyme Q10 is a very important compound that performs many functions in the human body. The most important function of coenzyme Q10 is participation in the production of energy in the mitochondria, which determines the proper functioning of all cells, tissues, and organs. The highest concentration of coenzyme Q10 is found in the tissue of the heart muscle. As the body ages, the concentration of coenzyme Q10 in the tissue of the heart muscle decreases, which makes it more susceptible to damage by free radicals. It has been shown that in patients with HF, the aggravation of disease symptoms is inversely related to the concentration of coenzyme Q10. Importantly, the concentration of coenzyme Q10 in patients with HF was an important predictor of the risk of death. Long-term coenzyme Q10 supplementation at a dose of 300 mg/day (Q-SYMBIO study) has been shown to significantly improve heart function and prognosis in patients with HF. This article summarizes the latest and most important data on CoQ10 in pathogenesis.

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Coenzyme Q10 and Cardiovascular Diseases

Cited by 47 publications

References 85 publications

Mitochondrial Management of Reactive Oxygen Species

Mitochondrial Management of Reactive Oxygen Species

Mediterranean Diet a Potential Strategy against SARS-CoV-2 Infection: A Narrative Review

Heart Failure—Do We Need New Drugs or Have Them Already? A Case of Coenzyme Q10

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