Coenzyme Q<sub>9</sub> Provides Cardioprotection after Converting into Coenzyme Q<sub>10</sub>

Lekli, István; Das, Somak Kumar; Das, Samarjit; Mukherjee, Subhendu; Bak, István; Juhász, Béla; Bagchi, Debasis; Golakoti, Trimurtulu; Krishnaraju, Alluri V.; Sengupta, Krishanu; Tósaki, Árpád; Das, Dipak K.

doi:10.1021/jf800035f

Cited by 16 publications

(16 citation statements)

References 30 publications

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“…Both CoQ 9 and CoQ 10 were detected in the human plasma SRM samples (supplementary Table VIB). Consistent with previous reports ( 44,46,47 ), CoQ 10 was the more abundant of the two ubiquinones, making up 94% of the total plasma CoQ. A total of 4.6 µmol/l of plasma ubiquinone was detected, slightly higher than previously published values ( 43,47,48 ).…”

Section: Prenol Lipidssupporting

confidence: 90%

“…The number of isoprene repeats varies among organisms, with yeast and bacteria possessing 6, 7, and 8 repeats (CoQ 6 , CoQ 7 , and CoQ 8 , respectively) and rats, mice, and humans possessing 9 and 10 repeats (CoQ 9 and CoQ 10 , respectively) ( 44 ). Our analysis of human plasma SRM focused on CoQ 9 and CoQ 10 , which are essential components of the mitochondrial electron transfer chain and thus required for ATP synthesis.…”

Section: Prenol Lipidsmentioning

confidence: 99%

“…Our analysis of human plasma SRM focused on CoQ 9 and CoQ 10 , which are essential components of the mitochondrial electron transfer chain and thus required for ATP synthesis. Clinical evidence suggests that CoQ 9 and CoQ 10 also possess cardioprotective properties, preventing ischemic damage to heart tissue and reducing ventricular dysfunction and cardiac arrhythmias associated with heart failure and acute myocardial infarction (44)(45)(46). Because the biosynthesis of CoQ is dependent upon the availability of farnesyl pyrophosphate produced by the mevalonate pathway, inhibition of the rate-limiting enzyme in this pathway, HMG-CoA reductase, by the cholesterol lowering statin drugs may lead to reductions in serum CoQ levels ( 46,47 ).…”

Section: Prenol Lipidsmentioning

confidence: 99%

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Lipidomics reveals a remarkable diversity of lipids in human plasma

Quehenberger

Armando

Brown

et al. 2010

Journal of Lipid Research

1,117

993

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In this era of genomics, transcriptomics, and proteomics, metabolomics is emerging as an important component of the omics evolution ( 1 ). Of the four kinds of biological molecules that comprise the human body, i.e., nucleic acids, amino acids (proteins), carbohydrates (sugars), and lipids (fats), lipids stand out among the various cellular metabolites in the sheer number of distinct molecular species. Using state-of-the-art lipidomics approaches made possible by newly developed instrumentation, protocols, and bioinformatics tools ( 2 ), the LIPID MAPS Consortium Abstract The focus of the present study was to defi ne the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test and physicians readily and regularly prescribe drugs that alter the levels of major plasma lipids such as cholesterol and triglycerides. Plasma contains many thousands of distinct lipid molecular species that fall into six main categories including fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterols, and prenols. The physiological contributions of these diverse lipids and how their levels change in response to therapy remain largely unknown. As a fi rst step toward answering these questions, we provide herein an in-depth lipidomics analysis of a pooled human plasma obtained from healthy individuals after overnight fasting and with a gender balance and an ethnic distribution that is representative of the US population. In total, we quantitatively assessed the levels of over 500 distinct molecular species distributed among the main lipid categories. As more information is obtained regarding the roles of individual lipids in health and disease, it seems likely that future blood tests will include an ever increasing number of these lipid molecules. -Quehenberger, O., A.

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Section: Prenol Lipidssupporting

confidence: 90%

Section: Prenol Lipidsmentioning

confidence: 99%

Section: Prenol Lipidsmentioning

confidence: 99%

See 1 more Smart Citation

Lipidomics reveals a remarkable diversity of lipids in human plasma

Quehenberger

Armando

Brown

et al. 2010

Journal of Lipid Research

1,117

993

View full text Add to dashboard Cite

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“…However, CoQ10 is mostly present in human tissue, whereas CoQ9 is found in the tissue of rodents. To distinguish between the endogenous (mainly Q9) and exogenous (only Q10) coenzymes, high-performance liquid chromatography (HPLC) or liquid chromatography/mass spectrometry (LC–MS/MS) was applied [ 12 , 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease?

Tsao

Hsu

Tseng

et al. 2021

Biology

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The aim of the study was to examine the potential effects of coenzyme Q10 (CoQ10) on reproductive function in a chronic kidney disease (CKD) mouse model. Nine-week-old mice were randomly assigned to two groups: sham surgery (n = 18) and CKD surgery (n = 18). After surgery, the study groups received CoQ10 (10 mg/kg body weight dissolved in corn oil by oral gavage) or corn oil as a vehicle daily for 8 weeks. The groups that underwent 5/6 nephrectomy developed significant elevations of serum BUN and creatinine levels. The CoQ10 treatment significantly increased the serum and testicular CoQ10 levels and alleviated the poor semen quality from incomplete spermatogenesis. The testosterone concentration, in addition to the protein expression of enzymes related to testosterone biosynthesis, was also elevated, and the CKD-induced decrease in antioxidant activity in the testes was significantly ameliorated. The results suggest that CoQ10 could act against CKD-induced testicular dysfunction through improvements in the sperm function, testicular morphology, testosterone levels and related biosynthesis pathways, in addition to antioxidant activity.

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“…5), CoQ, interacts directly with SDH (mitochondrial complex II), carrying electrons from the oxidation of succinate to complex III or inappropriately to complex I during reperfusion (Chouchani et al, 2014). CoQ functions also as an antioxidant (Lekli et al, 2008;Tsukahara et al, 1999) that stabilizes membranes, inhibits lipid peroxidation and is effective in treating ischemia-reperfusion injury. Hence, it is interesting that in addition to more sodiated CoQ, butterflies with the greatest decline in flight metabolic performance also had increased abundance of the unmodified parent CoQ.…”

Section: Discussionmentioning

confidence: 99%

Enzyme polymorphism, oxygen and injury: a lipidomic analysis of flight-induced oxidative damage in a SDH-polymorphic insect

Pekny

Smith

Marden

2018

Journal of Experimental Biology

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When active tissues receive insufficient oxygen to meet metabolic demand, succinate accumulates and has two fundamental effects: it causes ischemia-reperfusion injury while also activating the hypoxia-inducible factor pathway (HIF). The Glanville fritillary butterfly () possesses a balanced polymorphism in , shown previously to affect HIF pathway activation and tracheal morphology and used here to experimentally test the hypothesis that variation in succinate dehydrogenase affects oxidative injury We stimulated butterflies to fly continuously in a respirometer (3 min duration), which typically caused episodes of exhaustion and recovery, suggesting a potential for cellular injury from hypoxia and reoxygenation in flight muscles. Indeed, flight muscle from butterflies flown on consecutive days had lipidome profiles similar to those of rested paraquat-injected butterflies, but distinct from those of rested untreated butterflies. Many butterflies showed a decline in flight metabolic rate (FMR) on day 2, and there was a strong inverse relationship between the ratio of day 2 to day 1 FMR and the abundance of sodiated adducts of phosphatidylcholines and co-enzyme Q (CoQ). This result is consistent with elevation of sodiated lipids caused by disrupted intracellular ion homeostasis in mammalian tissues after hypoxia-reperfusion. Butterflies carrying the allele had a higher abundance of lipid markers of cellular damage, but the association was reversed in field-collected butterflies, where focal individuals typically flew for seconds at a time rather than continuously. These results indicate that Glanville fritillary flight muscles can be injured by episodes of high exertion, but injury severity appears to be determined by an interaction between SDH genotype and behavior (prolonged versus intermittent flight).

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Coenzyme Q₉ Provides Cardioprotection after Converting into Coenzyme Q₁₀

Cited by 16 publications

References 30 publications

Lipidomics reveals a remarkable diversity of lipids in human plasma

Lipidomics reveals a remarkable diversity of lipids in human plasma

Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease?

Enzyme polymorphism, oxygen and injury: a lipidomic analysis of flight-induced oxidative damage in a SDH-polymorphic insect

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Coenzyme Q9 Provides Cardioprotection after Converting into Coenzyme Q10

Cited by 16 publications

References 30 publications

Lipidomics reveals a remarkable diversity of lipids in human plasma

Lipidomics reveals a remarkable diversity of lipids in human plasma

Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease?

Enzyme polymorphism, oxygen and injury: a lipidomic analysis of flight-induced oxidative damage in a SDH-polymorphic insect

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Product

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Coenzyme Q₉ Provides Cardioprotection after Converting into Coenzyme Q₁₀