Coeliac disease--associated disorders and survival.

Collin, Pekka; Reunala, Timo; Pukkala, Eero; Laippala, Pékka; Keyriläinen, O; Pasternack, Amos

doi:10.1136/gut.35.9.1215

Cited by 434 publications

(310 citation statements)

References 29 publications

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“…52,53 The most well-known association is with dermatitis herpetiformis, a skin disease characterized by intensely pruritic papulovescicular lesions that occur symmetrically on the extensor surface of arms and legs and on the buttocks, trunk, neck and scalp. 54 All patients with dermatitis herpetiformis show glutendependent intestinal damage, which is indistinguishable from that of CD because it can present with mild clinical CD symptoms or with no symptoms at all.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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Until a few years ago, celiac disease (CD) was thought to be a rare food intolerance that was confined to childhood and characterized by severe malabsorption and flat intestinal mucosa. Currently, CD is regarded as an autoimmune disorder that is common in the general population (affecting 1 in 100 individuals), with possible onset at any age and with many possible presentations. The identification of CD is challenging because it can begin not only with diarrhea and weight loss but also with atypical gastrointestinal (constipation and recurrent abdominal pain) and extra-intestinal symptoms (anemia, raised transaminases, osteoporosis, recurrent miscarriages, aphthous stomatitis and associated autoimmune disorders), or it could be completely symptomless. Over the last 20 years, the diagnostic accuracy of serology for CD has progressively increased with the development of highly reliable tests, such as the detection of IgA tissue transglutaminase and antiendomysial and IgG antideamidated gliadin peptide antibodies. The routine use of antibody markers has allowed researchers to discover a very high number of 'borderline' cases, characterized by positive serology and mild intestinal lesions or normal small intestine architecture, which can be classified as potential CD. Therefore, it is evident that the 'old celiac disease' with flat mucosa is only a part of the spectrum of CD. It is possible that serology could identify CD in its early stages, before the appearance of severe intestinal damage. In cases with a positive serology but with mild or absent intestinal lesions, the detection of HLA-DQ2 and HLA-DQ8 can help reinforce or exclude the diagnosis of gluten sensitivity.

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Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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“…5,6 Many patients with gluten-sensitive enteropathy may have subclinical or only mildly symptomatic disease, and the classic presentation with steatorrhea, weight loss, or dermatitis herpetiformis represents the more severe end of the spectrum. In addition to patients with classic presentations, others suitable for serologic screening are those with clinical characteristics that have a strong statistical association with celiac disease, such as type I diabetes mellitus, thyroid disease, iron or folic acid deficiency, and a family history of celiac disease.…”

mentioning

confidence: 99%

DisseminatedEncephalitozoon (Septata) intestinalisInfection in a Patient with AIDS

Franzen¹,

Müller²,

Hartmann³

et al. 1996

N Engl J Med

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“…The observation of shared susceptibility loci with type 1 diabetes is not unexpected given that coeliac disease is more common in patients with diabetes and vice versa (42,43) . Indeed, at least three loci show some evidence of being involved in both diseases, these loci being the IL-2 and IL-21, the CCR genes and the SH2B3 regions.…”

Section: Advances In Genetics Of Coeliac Diseasementioning

confidence: 99%

Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on ‘Nutrition and autoimmune disease’

Feighery

McManus

2009

Proc. Nutr. Soc.

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Over the past 20 years major advances have been made in the diagnosis and understanding of pathogenic mechanisms relating to coeliac disease. Recently-identified genetic markers support the immunological–inflammatory nature of the disease. It is hoped that these newly-identified genes will assist further dissection of the inflammatory pathways in coeliac disease and give insight into why certain individuals develop intolerance to dietary gluten.

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Coeliac disease--associated disorders and survival.

Abstract: The associated diseases in 335 coeliac patients diagnosed 1980-90 were compared with age and sex matched control patients with various gastrointestinal symptoms. Endocrine disorders were found in 11.9% of coeliac and 4.

Cited by 434 publications

References 29 publications

Celiac disease: diagnostic criteria in progress

Celiac disease: diagnostic criteria in progress

DisseminatedEncephalitozoon (Septata) intestinalisInfection in a Patient with AIDS

Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on ‘Nutrition and autoimmune disease’

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