Coeliac disease and (extra)intestinal T-cell lymphomas: definition, diagnosis and treatment

Evaluation of enteropathy-associated T-cell lymphoma comparing standard therapies with a novel regimen including autologous stem cell transplantation

“…4 The relation between EATL and CD is well established. 5,7,[11][12][13] However, EATL may also be diagnosed in patients without a history of CD. 4 The tumor may occur in any part of the gastrointestinal tract but predominantly arises in the jejunum.…”

NK-cell enteropathy: a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma: clinicopathologic features and follow-up in a unique case series

“…These lymphomas are almost always associated with Epstein-Barr virus (EBV) and have not been linked with celiac disease. [2][3][4] The nasal cavity and upper aerodigestive tract are the most common sites of origin, but involvement of the gastrointestinal tract is common and the gastrointestinal tract may be the primary site of presentation. 5 The differential diagnosis of gastrointestinal NK-cell and T-cell lymphomas includes enteropathyassociated T-cell lymphoma (EATL; commonly associated with active or latent celiac disease), ␥␦ T-cell lymphoma, and more rarely anaplastic large cell lymphoma, anaplastic lymphoma kinasepositive.…”

Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells

“…28 For radiologic evaluation, the patients underwent whole-body CT scanning and whole-body PET to exclude intestinal and extraintestinal localization of EATL. 29,30 Immunophenotyping of IELs IELs were isolated from 3 duodenal biopsies by passing them through nylon filters (1 ϫ 100 m, 1 ϫ 40 m, BD Biosciences, Discovery Labware, Bedford, MA). Cells were stained with fluorescent-labeled monoclonal antibodies to CD3, CD7, CD8, CD45, CD103, and TCR␥␦, as well as with relevant isotype controls.…”