“…In comparison to electron, photon or proton dosimetry, carbon ion dosimetry has to be developed and is currently connected with larger uncertainties [12]. Currently, practiced protocols for clinical proton/HCP dosimetry, such as the AAPM report 16 [13], ECHED code of practice and its supplement [14,15], ICRU report 59 [16] and IAEA TRS-398 [17] recommend cylindrical ionization chambers as reference instruments without taking into account any correction factors for the presence of the ionization chambers in the field. The overall uncertainty in the determination of the absorbed dose in an ion beam is quoted to be 2.8% for cylindrical chambers and 3.2% for plane-parallel chambers.…”