Cochlear Implantation Outcomes in Adults With Single-Sided Deafness: A Systematic Review and Meta-analysis

Daher, Ghazal S.; Kocharyan, Arminé; Dillon, Margaret T.; Carlson, Matthew L.

doi:10.1097/mao.0000000000003833

Cited by 13 publications

(8 citation statements)

References 60 publications

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“…Satisfactory hearing rehabilitation and improvement in quality of life after cochlear implantation have been demonstrated in numerous studies [ 36 , 37 ]. The positive impact of cochlear implantation on psychological comorbidities or concomitant tinnitus has also been noted in some studies [ 19 , 20 , 37 , 38 ]. However, previous research has rarely considered the importance of mental health and personality factors in subjective outcomes.…”

Section: Discussionmentioning

confidence: 99%

Influence of depressive disorders, stress, and personality traits on quality of life after cochlear implantation

Lailach,

Stephan,

Martin

et al. 2023

Eur Arch Otorhinolaryngol

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Purpose This study aimed to determine whether preoperative depressiveness, stress, and personality influence quality of life (QOL) after cochlear implant (CI) surgery. Methods In this prospective study, 79 patients undergoing CI surgery were evaluated preoperatively and 12 months postoperatively. Disease-specific QOL was assessed with the Nijmegen Cochlear Implant Questionnaire (NCIQ) and general QOL with the WHOQOL-BREF. Depressiveness and stress were assessed with the Patient Health Questionnaire (PHQ-D). The Charlson Comorbidity Index (CCI) was used to classify comorbidities. The Big Five Personality Test (B5T) was used to assess the basic personality dimensions. Speech comprehension was evaluated in quiet with the Freiburg monosyllable test and in noise with the Oldenburg sentence test. Results After CI surgery, the total NCIQ score improved significantly (Δ 17.1 ± 14.7, p < 0.001). General QOL (WHOQOL-BREF, Δ 0.4 ± 9.9, p = 0.357), stress (Δ 0.25 ± 3.21, p = 0.486), and depressiveness (Δ 0.52 ± 3.21, p = 0.121) were unaffected by CI surgery. Patients without elevated depressiveness (p < 0.01) or stress (p < 0.001) had significantly better total NCIQ scores. The results of the multiple regression analyses show that, after adjusting for the CCI, personality, age, and mental health stress (ß = − 0.495, p < 0.001) was significantly associated with postoperative NCIQ outcome scores. Depressiveness and neuroticism had the strongest influence on the generic QOL (ß = − 0.286 and ß = − 0.277, p < 0.05). Conclusion Stress symptoms and personality traits are significant predictive factors for disease-specific QOL, as well as hearing status. This should be considered in the preoperative consultation and in optimizing the rehabilitation process.

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Section: Discussionmentioning

confidence: 99%

Influence of depressive disorders, stress, and personality traits on quality of life after cochlear implantation

Lailach,

Stephan,

Martin

et al. 2023

Eur Arch Otorhinolaryngol

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“…While previous studies have investigated quality of life changes related to SSD-CI, to our knowledge this is one of the first studies to measure health utility ( Daher et al, 2023 ). HUI3 is a validated health utility instrument that allows not only comparison to other disease states but also downstream calculation of quality adjusted life years and cost-effectiveness, which are important measures for future health economic studies.…”

Section: Discussionmentioning

confidence: 99%

“…Cochlear implantation has emerged as an important tool in the clinical treatment of SSD, with demonstrated benefit for hearing, tinnitus, and quality of life ( Van de Heyning et al, 2008 ; Arndt et al, 2017 ; Daher et al, 2023 ). In contrast to traditional strategies such as Contralateral Routing of Signal (CROS) or Osseointegrated Hearing Aids (OHA), a cochlear implant (CI) is the only device able to restore input to the deafened ear, and therefore provide some degree of bilateral function ( Ericson et al, 1988 ; Hagr, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Cochlear implantation in unilateral hearing loss: impact of short- to medium-term auditory deprivation

Ullah,

Cevallos,

Shen

et al. 2023

Front. Neurosci.

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IntroductionSingle sided deafness (SSD) results in profound cortical reorganization that presents clinically with a significant impact on sound localization and speech comprehension. Cochlear implantation (CI) has been approved for two manufacturers’ devices in the United States to restore bilateral function in SSD patients with up to 10 years of auditory deprivation. However, there is great variability in auditory performance and it remains unclear how auditory deprivation affects CI benefits within this 10-year window. This prospective study explores how measured auditory performance relates to real-world experience and device use in a cohort of SSD-CI subjects who have between 0 and 10 years of auditory deprivation.MethodsSubjects were assessed before implantation and 3-, 6-, and 12-months post-CI activation via Consonant-Nucleus-Consonant (CNC) word recognition and Arizona Biomedical Institute (AzBio) sentence recognition in varying spatial speech and noise presentations that simulate head shadow, squelch, and summation effects (S0N0, SSSDNNH, SNHNSSD; 0 = front, SSD = impacted ear, NH = normal hearing ear). Patient-centered assessments were performed using Tinnitus Handicap Inventory (THI), Spatial Hearing Questionnaire (SHQ), and Health Utility Index Mark 3 (HUI3). Device use data was acquired from manufacturer software. Further subgroup analysis was performed on data stratified by <5 years and 5–10 years duration of deafness.ResultsIn the SSD ear, median (IQR) CNC word scores pre-implant and at 3-, 6-, and 12-months post-implant were 0% (0–0%), 24% (8–44%), 28% (4–44%), and 18% (7–33%), respectively. At 6 months post-activation, AzBio scores in S0N0 and SSSDNNH configurations (n = 25) demonstrated statistically significant increases in performance by 5% (p = 0.03) and 20% (p = 0.005), respectively. The median HUI3 score was 0.56 pre-implant, lower than scores for common conditions such as anxiety (0.68) and diabetes (0.77), and comparable to stroke (0.58). Scores improved to 0.83 (0.71–0.91) by 3 months post-activation. These audiologic and subjective benefits were observed even in patients with longer durations of deafness.DiscussionBy merging CI-associated changes in objective and patient-centered measures of auditory function, our findings implicate central mechanisms of auditory compensation and adaptation critical in auditory performance after SSD-CI and quantify the extent to which they affect the real-world experience reported by individuals.

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“…Studies investigating clinical and behavioral outcomes after single-sided CI implantation generally show beneficial effects of the intervention in both children (Benchetrit et al, 2021;Park et al, 2023;Patro et al, 2023) and adults (Andren et al, 2023;Daher et al, 2023;Deep et al, 2021;Oh et al, 2023;Ullah et al, 2023). These positive outcomes are reflected in increased performance in directional hearing, improved speech-in-noise performance, enhanced quality of life, reduced listening effort, and suppression of tinnitus (Benchetrit et al, 2021;Daher et al, 2023;Oh et al, 2023;Peter, Liyanage, et al, 2019). Overall, cochlear implantation has brought about positive outcomes for people with SSD.…”

Section: Introductionmentioning

confidence: 99%

“…It is important to note that a combination of these factors can lead to SSD. Treatments for SSD include hearing aids, bone conduction devices, and cochlear implants (CI) (Daher et al, 2023;Kay-Rivest, Schlacter, et al, 2022;Snapp & Ausili, 2020). Diagnostic criteria for SSD typically involve measuring pure tone hearing thresholds in both ears between 125 and 8000 Hz (in octave or semi-octave steps).…”

Section: Introductionmentioning

confidence: 99%

Cochlear implantation in adults with acquired single-sided deafness improves cortical processing and comprehension of speech presented to the non-implanted ears: A longitudinal EEG study

Chen,

Neff,

Leske

et al. 2023

Preprint

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Former studies have established that individuals with a cochlear implant (CI) for treating single-sided deafness (SSD) experience improved speech processing after implantation. However, it is not clear how each ear contributes separately to improve speech perception over time at the behavioral and neural level. In this longitudinal EEG study with four different time points, we measured neural activity in response to variously degraded spoken words presented monaurally to the CI and non-CI ears in 10 single-sided CI users and 10 age- and sex-matched individuals with normal hearing. Subjective comprehension ratings for each word were also recorded. Data from single-sided CI participants were collected : pre-CI implantation, and at 3, 6, and 12 months after implantation. We conducted a time-resolved representational similarity analysis (RSA) on the EEG data to depict whether and how neural patterns became more similar to those of healthy individuals. The analysis was performed separately for the CI and non-CI ear. At 6 months post implantation, the speech comprehension ratings for the degraded words improved in both ears. Notably, the improvement was more pronounced for the non-CI ear than the CI ear. Furthermore, the enhancement in non-CI ears was paralleled by increased similarity to neural representational patterns of the normal hearing control group. The maximum of this effect was observed between 600 and 1200 ms after stimulus onset, coinciding with the peak decoding accuracy for spoken-word comprehension. The present study demonstrates that auditory cortical speech processing gradually normalizes in the non-CI ear after CI implantation within months. The CI enables the deaf ear to provide afferent input, which, according to our results, complements the input of the non-CI, gradually improving its function. These novel findings underscore the feasibility of tracking neural recovery after auditory input restoration using advanced multivariate analysis methods, such as RSA.

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Cochlear Implantation Outcomes in Adults With Single-Sided Deafness: A Systematic Review and Meta-analysis

Cited by 13 publications

References 60 publications

Influence of depressive disorders, stress, and personality traits on quality of life after cochlear implantation

Influence of depressive disorders, stress, and personality traits on quality of life after cochlear implantation

Cochlear implantation in unilateral hearing loss: impact of short- to medium-term auditory deprivation

Cochlear implantation in adults with acquired single-sided deafness improves cortical processing and comprehension of speech presented to the non-implanted ears: A longitudinal EEG study

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