Cochlear Implant Surgery

Mowry, Sarah E.; Woodson, Erika

doi:10.1001/jamaoto.2019.2274

Cited by 4 publications

(2 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hair cell damage-related hearing impairments can be treated with cochlear implants to restore hearing, 12 , 13 however, degeneration or loss of SGNs can result in irreversible hearing loss because they lack the capacity to regenerate. 10 Roughly 10% of individuals with hearing impairment are thought to have SNHL.…”

Section: Introductionmentioning

confidence: 99%

Optogenetically modified human embryonic stem cell-derived otic neurons establish functional synaptic connection with cochlear nuclei

Chen,

Mu,

et al. 2024

J Tissue Eng

View full text Add to dashboard Cite

Spiral ganglia neurons (SGNs) impairment can cause deafness. One important therapeutic approach involves utilizing stem cells to restore impaired auditory circuitry. Nevertheless, the inadequate implementation of research methodologies poses a challenge in accurately assessing the functionality of derived cells within the circuit. Here, we describe a novel method for converting human embryonic stem cells (hESCs) into otic neurons (ONs) and assess their functional connectivity using an optogenetic approach with cells or an organotypic slice of rat cochlear nucleus (CN) in coculture. Embryonic stem cell-derived otic neurons (eONs) exhibited SGN marker expression and generated functional synaptic connection when cocultured with cochlear nucleus neurons (CNNs). Synapsin 1 and VGLUT expression are found in the cochlear nucleus of brain slices, where eONs projected processes during the coculture of eONs and CN brain slices. Action potential spikes and INa+/IK+ of CNNs increased in tandem with light stimulations to eONs. These findings provide further evidence that eONs may be a candidate source to treat SGN-deafness.

show abstract

Section: Introductionmentioning

confidence: 99%

Optogenetically modified human embryonic stem cell-derived otic neurons establish functional synaptic connection with cochlear nuclei

Chen,

Mu,

et al. 2024

J Tissue Eng

View full text Add to dashboard Cite

show abstract

“…Currently, cochlear implantation (CI) is the most effective treatment to partially restore hearing for patients with profound‐to‐severe sensorineural hearing loss. 1 Through an electrode array implanted into the cochlea, 2 acoustic signals are transcoded into electrical signals. Therefore, the outcome of CI is largely relying on the effectiveness of the electrical signals delivered by the CI electrodes.…”

Section: Introductionmentioning

confidence: 99%

Electrical stimulation of cochlear implant promotes activation of macrophages and fibroblasts under inflammation

Zhang,

Chen,

Wang

et al. 2023

Laryngoscope Investig Oto

View full text Add to dashboard Cite

ObjectivesThe implanted electrodes deliver electric signals to spiral ganglion neurons, conferring restored hearing of cochlear implantation (CI) recipients. Postimplantation intracochlear fibrosis, which is observed in most CI recipients, disturbs the electrical signals and impairs the long‐term outcome of CI. The macrophages and fibroblasts activation is critical for the development of intracochlear fibrosis. However, the effect of electric stimulation of cochlear implant (ESCI) on the activity of macrophages and fibroblasts was unclear. In the present study, a human cochlear implant was modified to stimulate cultured macrophages and fibroblasts.MethodsBy measuring cellular marker and the expression level of cytokine production, the polarization and activity of macrophages and fibroblasts were examined with or without ESCI.ResultsOur data showed that ESCI had little effects on the morphology, density, and distribution of culturing macrophages and fibroblasts. Furthermore, ESCI alone did not affect the polarization of macrophages or the function of fibroblasts without the treatment of inflammatory factors. However, in the presence of LPS or IL‐4, ESCI further promoted the polarization of macrophages, and increased the expression of pro‐inflammatory or anti‐inflammatory factors, respectively. For fibroblasts, ESCI further increased the collagen I synthesis induced by TGF‐β1 treatment. Nifedipine inhibited ESCI induced calcium influx, and hereby abolished the promoted polarization and activation of macrophages and fibroblasts.ConclusionOur results suggest that acute inflammation should be well inhibited before the activation of cochlear implants to control the postoperative intracochlear fibrosis. The voltage‐gated calcium channels could be considered as the targets for reducing postimplantation inflammation and fibrosis.Level of EvidenceNA.

show abstract

Ipsilateral single stage conversion from BAHA to cochlear implant

Hrisomalos

Semaan

et al. 2015

American Journal of Otolaryngology

View full text Add to dashboard Cite

Cochlear Implant Surgery

Cited by 4 publications

References 72 publications

Optogenetically modified human embryonic stem cell-derived otic neurons establish functional synaptic connection with cochlear nuclei

Optogenetically modified human embryonic stem cell-derived otic neurons establish functional synaptic connection with cochlear nuclei

Electrical stimulation of cochlear implant promotes activation of macrophages and fibroblasts under inflammation

Ipsilateral single stage conversion from BAHA to cochlear implant

Contact Info

Product

Resources

About