Coccidioidomycosis in Infants

Neonatal Coccidioidomycosis

“…In our patients, symptoms started within the first 1-4 weeks of life, but coccidioidomycosis was not diagnosed until months later, similar to what has been reported previously. 13,18,20 All our patients had abnormal chest radiographs, with infiltrates and mediastinal adenopathy, and each grew C. immitis/posadasii. Airway narrowing was noted on bronchoscopy and chest CT scan on 2 patients who required steroid therapy to manage respiratory compromise.…”

“…Coccidioidomycosis in infants younger than 1 month of age is rare, and it has been more than 2 decades since the last published case report. [13][14][15][16][17][18][19][20][21] We identified 3 cases of neonatal coccidioidomycosis at our institution over a 6-year period. In our patients, symptoms started within the first 1-4 weeks of life, but coccidioidomycosis was not diagnosed until months later, similar to what has been reported previously.…”

Endocarditis Caused by Coccidioides Species

“…Five cases met the Duke criteria 3 for definite endocarditis based on histopathologic findings from the involved heart valve. The patient described by Townsend and McKey 9 (Table 1) had valvular vegetations demonstrat- [8][9][10] (current report) or not reported. 11…”

Neonatal Coccidioidomycosis: A Case Report

“… 7 , 11 Neonatal coccidioidomycosis, regardless of the mode of transmission, has a high mortality rate, often with evidence of disseminated disease and multiorgan involvement found on autopsy. 3 , 6 , 9 , 11 …”

“…There are 2 other cases of neonatal coccidioidomycosis reported with cutaneous manifestations, however, in both cases described, the infants also had systemic findings, including pneumonia. 7,11 Neonatal coccidioidomycosis, regardless of the mode of transmission, has a high mortality rate, often with evidence of disseminated disease and multiorgan involvement found on autopsy. 3,6,9,11 There has been a paucity of literature on neonatal coccidioidomycosis despite the increasing incidence of coccidioidomycosis starting in the 1990s and peaking in 2011.…”