Cobalamin status during normal pregnancy and postpartum: a longitudinal study comprising 406 Danish women

Milman, Nils; Byg, Keld-Erik; Bergholt, Thomas; Eriksen, Lisbeth; Hvas, Anne‐Mette

doi:10.1111/j.0902-4441.2006.t01-1-ejh2550.x

Cited by 61 publications

(86 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ten of the 11 studies that reported the mean showed a consistent decrease in vitamin B-12 concentrations from the first to the third (91,95), from the second to the third (28,45,46,81,87), and from the first to the second to the third (85,96,98) trimesters. The exception was the study by Marzan et al (83), which showed a marginal increase in mean vitamin B-12 concentrations across the pregnancy (266, 270, and 286 pmol/L in the first, second, and third trimesters, respectively), despite the participants not (19,84).…”

Section: Mean Vitamin B-12 Concentrations Across Trimestersmentioning

confidence: 92%

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Sukumar

Rafnsson

Kandala

et al. 2016

The American Journal of Clinical Nutrition

103

View full text Add to dashboard Cite

Background: Vitamin B-12 and folate are micronutrients essential for normal embryogenesis. Vitamin B-12 insufficiency in pregnancy is high in certain parts of the world, such as India, and although this has been linked to low birth weight (LBW) in these populations, the relation between vitamin B-12 and birth weight (BW) elsewhere is unknown. Objectives: We performed a systematic review to assess 1) the worldwide prevalence of vitamin B-12 insufficiency in pregnancy and 2) its association with BW. Design: A search of 5 electronic databases was performed to identify eligible articles. Random-effects meta-analysis was conducted according to geographic regions and pregnancy trimesters for the prevalence subreview and by categorical measures of BW. Results: A total of 57 and 23 articles were included for the prevalence and BW subreviews, respectively. The pooled estimates of vitamin B-12 insufficiency were 21%, 19%, and 29% in the first, second, and third trimesters, respectively, with high rates for the Indian subcontinent and the Eastern Mediterranean. The large heterogeneity between studies was partially addressed by creating a standardized score for each study (mean vitamin B-12 insufficiency O cutoff value), which internally corrected for geographic region, trimester, and assay type. Twelve of the 13 longitudinal studies included showed a decrease in mean or median vitamin B-12 across trimesters. Pooled analysis showed nonsignificantly lower maternal vitamin B-12 concentrations in LBW than in normal-BW infants and higher odds of LBW with lower vitamin B-12 values (adjusted OR: 1.70; 95% CI: 1.16, 2.50), but studies from India largely contributed to the latter. Conclusions: Our review indicates that vitamin B-12 insufficiency during pregnancy is common even in nonvegetarian populations and that concentrations of vitamin B-12 decrease from the first to the third trimester. There is no consistent association between vitamin B-12 insufficiency and LBW. However, given the long-term risks of LBW, this observation warrants further cohort studies and randomized controlled trials.Am J Clin Nutr 2016;103:1232-51.

show abstract

Section: Mean Vitamin B-12 Concentrations Across Trimestersmentioning

confidence: 92%

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Sukumar

Rafnsson

Kandala

et al. 2016

The American Journal of Clinical Nutrition

103

View full text Add to dashboard Cite

show abstract

“…Vitamin B12 can only be obtained from animal products [63]. More than 1000 μg of vitamin B12 is stored in fertile women eating a mixed diet 63 . At term, foetal vitamin B12 stores should be 25-50 μg 64 .…”

Section: Vitamin B-12 Deficiencymentioning

confidence: 99%

Prevalence of Anemia Among Pregnant Women in Ethiopia and Its Management: A Review

Tsegaye¹,

Tesfaye²

2014

Int. Res. J. Pharm.

View full text Add to dashboard Cite

Anemia is a major global health problem, especially in developing countries and is a common and serious problem in pregnancy. It has serious short-and long-term consequences during pregnancy and beyond. This fundamental health issue has not still been solved but continues to exist affecting the health, quality of life and working capacity in billions of people all over the world. The anemic condition is often worsened by the presence of other chronic diseases such as malaria, tuberculosis, HIV, and diabetes. Untreated anemia also leads to increased morbidity and mortality from these chronic conditions as well. Current knowledge indicates that iron deficiency anemia in pregnancy is a risk factor for preterm delivery and subsequent low birth weight, and possibly for inferior neonatal health. Even for women who enter pregnancy with reasonable iron stores, iron supplements improve iron status during pregnancy and for a considerable length of time postpartum, thus providing some protection against iron deficiency in the subsequent pregnancy. This literature review focuses on the prevalence and major causes of anemia seen on a global & Ethiopian scale. Most cases of anemia are due to iron deficiency, which often work in combination with folate deficiency and/or vitamin B12 deficiency as well as with infections. More efforts should be dedicated to tackle this massive problem-we have the tools and we know the ways. Iron fortification of appropriate food items combined with iron supplements in specific population groups has proved to be efficient. Initially, the efforts should be centered on the specific risk groups for iron deficiency anemia, i.e. pregnant women.

show abstract

“…Plasma cobalamins 2 were measured on the Microparticle Enzyme Immunoassay technology (Abbott Diagnostics, IL, USA). ELISA assays were used to measure TC and HC (holo and total) in serum.…”

mentioning

confidence: 99%

Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum

Mørkbak¹,

Hvas²,

Milman³

et al. 2007

Haematologica

View full text Add to dashboard Cite

We confirm a decrease in cobalamins during pregnancy, and report that the active part of cobalamins (holotranscobalamin, holoTC) remains unchanged. The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 deficiency during pregnancy. Haematologica 2007; 92:1711 92: -1712 We studied the interrelations between cobalamins, TC and HC (holo and total) during pregnancy in a follow-up study of pregnant women previously described in detail.

show abstract

Cobalamin status during normal pregnancy and postpartum: a longitudinal study comprising 406 Danish women

Abstract: Low cobalamin status may occur among pregnant women, especially in late pregnancy. The recommendations for periconceptional vitamin B(12) supplementation should be reconsidered.

Cited by 61 publications

References 13 publications

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Prevalence of Anemia Among Pregnant Women in Ethiopia and Its Management: A Review

Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum

Contact Info

Product

Resources

About