Coaxial nanofibers outperform uniaxial nanofibers for the loading and release of pyrroloquinoline quinone (PQQ) for biomedical applications

Ibrahim, Sara; Rezk, Marwan Y.; Ismail, Mousa A. M.; Abdelrahman, Taghrid; Sharkawy, Mona; Abdellatif, Ahmed; Allam, Nageh K.

doi:10.1039/d0na00311e

Cited by 19 publications

(19 citation statements)

References 40 publications

(50 reference statements)

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“…In biomedical applications, coaxial nanofibers are superior to uniaxial nanofibers in terms of drug loading and releasing (165). The biggest characteristic of coreshell structure is that the release process of drugs can be better controlled to prevent drugs from being released prematurely, and the existence of core-shell structure can avoid the destruction of physical and chemical properties of drugs in the core layer by the external environment.…”

Section: Functional Applications Of Structural Electrospun Fibersmentioning

confidence: 99%

Structural design toward functional materials by electrospinning: A review

et al. 2020

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Electrospinning as one of the most versatile technologies have attracted a lot of scientists’ interests in past decades due to its great diversity of fabricating nanofibers featuring high aspect ratio, large specific surface area, flexibility, structural abundance, and surface functionality. Remarkable progress has been made in terms of the versatile structures of electrospun fibers and great functionalities to enable a broad spectrum of applications. In this article, the electrospun fibers with different structures and their applications are reviewed. First, several kinds of electrospun fibers with different structures are presented. Then the applications of various structural electrospun fibers in different fields, including catalysis, drug release, batteries, and supercapacitors, are reviewed. Finally, the application prospect and main challenges of electrospun fibers are discussed. We hope that this review will provide readers with a comprehensive understanding of the structural design and applications of electrospun fibers in different fields.

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Section: Functional Applications Of Structural Electrospun Fibersmentioning

confidence: 99%

Structural design toward functional materials by electrospinning: A review

et al. 2020

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“…The desired morphologies and structures of nanofibers can be achieved towards a diverse combination of complementary materials in the complicated core-shell composite structures fabricated via coaxial electrospinning [ 25 , 31 , 32 , 33 , 34 ]. Compared to uniaxial electrospinning in which a single needle is used, coaxial electrospinning requires two concentric needles with different polymer solutions to produce the core and shell of composite nanofibers [ 31 , 35 , 36 ]. Considerable efforts have been dedicated to the multifunctional properties and novelty of electrospun composite nanofibers which hold great potential for electronic devices, biomedicine, and tissue regeneration [ 35 , 37 , 38 , 39 , 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

“…Compared to uniaxial electrospinning in which a single needle is used, coaxial electrospinning requires two concentric needles with different polymer solutions to produce the core and shell of composite nanofibers [ 31 , 35 , 36 ]. Considerable efforts have been dedicated to the multifunctional properties and novelty of electrospun composite nanofibers which hold great potential for electronic devices, biomedicine, and tissue regeneration [ 35 , 37 , 38 , 39 , 40 , 41 ]. The superior combination of the complementary polymers in the core and shell structure is beneficial to the mechanical properties over the neat polymers [ 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Tunable Mechanical and Electrical Properties of Coaxial Electrospun Composite Nanofibers of P(VDF-TrFE) and P(VDF-TrFE-CTFE)

Lam

Hsiao

et al. 2021

IJMS

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The coaxial core/shell composite electrospun nanofibers consisting of relaxor ferroelectric P(VDF-TrFE-CTFE) and ferroelectric P(VDF-TrFE) polymers are successfully tailored towards superior structural, mechanical, and electrical properties over the individual polymers. The core/shell-TrFE/CTFE membrane discloses a more prominent mechanical anisotropy between the revolving direction (RD) and cross direction (CD) associated with a higher tensile modulus of 26.9 MPa and good strength-ductility balance, beneficial from a better degree of nanofiber alignment, the increased density, and C-F bonding. The interfacial coupling between the terpolymer P(VDF-TrFE-CTFE) and copolymer P(VDF-TrFE) is responsible for comparable full-frequency dielectric responses between the core/shell-TrFE/CTFE and pristine terpolymer. Moreover, an impressive piezoelectric coefficient up to 50.5 pm/V is achieved in the core/shell-TrFE/CTFE composite structure. Our findings corroborate the promising approach of coaxial electrospinning in efficiently tuning mechanical and electrical performances of the electrospun core/shell composite nanofiber membranes-based electroactive polymers (EAPs) actuators as artificial muscle implants.

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“…Coaxial electrospinning provides a strategy to fabricate core-shell structure nanofibers as a drug delivery system. It was reported that coaxial nanofibers exhibited lower release rates compared to that of uniaxial nanofibers, resulting in a prolonged release [156]. Recently, various drug delivery systems fabricated by coaxial electrospinning were reported.…”

Section: Drug Delivery Systemmentioning

confidence: 99%

Fibers by Electrospinning and Their Emerging Applications in Bone Tissue Engineering

et al. 2021

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Bone tissue engineering (BTE) is an optimized approach for bone regeneration to overcome the disadvantages of lacking donors. Biocompatibility, biodegradability, simulation of extracellular matrix (ECM), and excellent mechanical properties are essential characteristics of BTE scaffold, sometimes including drug loading capacity. Electrospinning is a simple technique to prepare fibrous scaffolds because of its efficiency, adaptability, and flexible preparation of electrospinning solution. Recent studies about electrospinning in BTE are summarized in this review. First, we summarized various types of polymers used in electrospinning and methods of electrospinning in recent work. Then, we divided them into three parts according to their main role in BTE, (1) ECM simulation, (2) mechanical support, and (3) drug delivery system.

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Coaxial nanofibers outperform uniaxial nanofibers for the loading and release of pyrroloquinoline quinone (PQQ) for biomedical applications

Abstract: Pyrroloquinoline quinone (PQQ), present in breast milk and various foods, is highly recommended as an antioxidant, anti-inflammatory agent, and a cofactor in redox reactions in several biomedical fields.

Cited by 19 publications

References 40 publications

Structural design toward functional materials by electrospinning: A review

Structural design toward functional materials by electrospinning: A review

Tunable Mechanical and Electrical Properties of Coaxial Electrospun Composite Nanofibers of P(VDF-TrFE) and P(VDF-TrFE-CTFE)

Fibers by Electrospinning and Their Emerging Applications in Bone Tissue Engineering

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