Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome

Abstract

Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome.

Follicular Aspiration Is Superior to Coasting as Effective Prophylactic Procedure against Ovarian Hyperstimulation Syndrome

“…Furthermore, about 75% of patients developed mild symptoms ranging between grade one and two. The obtained results concerning patients received coasting procedure are in line D'Angelo et al [23] who reviewed RCT assessed the effect of coasting on prevention of OHSS and reported lower rates of OHSS with coasting versus no coasting by rates suggesting that if 45% of women developed moderate or severe OHSS without coasting, only 4% -17% would develop it with coasting. Also, Abide Yayla et al [24] in their retrospective study of women used coasting to avoid OHSS in 100 high-risk women and documented that all women had reached to embryo transfer stage and reported clinical pregnancy rate of 44%.…”

Follicular Aspiration Is Superior to Coasting as Effective Prophylactic Procedure against Ovarian Hyperstimulation Syndrome

“…Furthermore, about 75% of patients developed mild symptoms ranging between grade one and two. The obtained results concerning patients received coasting procedure are in line D'Angelo et al [23] who reviewed RCT assessed the effect of coasting on prevention of OHSS and reported lower rates of OHSS with coasting versus no coasting by rates suggesting that if 45% of women developed moderate or severe OHSS without coasting, only 4% -17% would develop it with coasting. Also, Abide Yayla et al [24] in their retrospective study of women used coasting to avoid OHSS in 100 high-risk women and documented that all women had reached to embryo transfer stage and reported clinical pregnancy rate of 44%.…”

Safety of Ovaleap® (Follitropin Alfa) in Infertile Women Undergoing Superovulation for Assisted Reproductive Technologies: A Multinational Comparative, Prospective Cohort Study

“…reported in the clinical development program of Ovaleap ® and in a post marketing study (9,10,13). Moreover, little difference was observed between the cohorts within each severity grading and OHSS severity level incidence proportions were compatible with the background rate described in the literature (4,5).…”

“…Previously identified OHSS risk factors (3,4) that were confirmed to be associated with the incidence of OHSS in the SOFIA study include PCOS, having an embryo transfer, antral follicle count, basal serum AMH, FSH dose reduction, FSH treatment duration, and pregnancy. Other risk factors such as age and BMI were not found to be associated with OHSS, possibly due to the fact that a minority of the women were younger (<30 years) and/or had a low BMI.…”

Risk factors, management, and future fertility of empty follicle syndrome: a retrospective study with real-world data

“…An accidental hCG injection mistake, as seen in our study, can halt ovarian stimulation without triggering ovulation, which was similar to “coasting”. Previous studies showed that 1 to 2 days of “coasting” is harmless ( 22 , 23 ). Stevenson reported live births in six out of 14 similar cases after rescue hCG injection, suggesting that oocyte and embryo quality may not be compromised ( 24 ).…”

Follicular Aspiration Is Superior to Coasting as Effective Prophylactic Procedure against Ovarian Hyperstimulation Syndrome

“…Furthermore, about 75% of patients developed mild symptoms ranging between grade one and two. The obtained results concerning patients received coasting procedure are in line D'Angelo et al [23] who reviewed RCT assessed the effect of coasting on prevention of OHSS and reported lower rates of OHSS with coasting versus no coasting by rates suggesting that if 45% of women developed moderate or severe OHSS without coasting, only 4% -17% would develop it with coasting. Also, Abide Yayla et al [24] in their retrospective study of women used coasting to avoid OHSS in 100 high-risk women and documented that all women had reached to embryo transfer stage and reported clinical pregnancy rate of 44%.…”

Safety of Ovaleap® (Follitropin Alfa) in Infertile Women Undergoing Superovulation for Assisted Reproductive Technologies: A Multinational Comparative, Prospective Cohort Study

“…reported in the clinical development program of Ovaleap ® and in a post marketing study (9,10,13). Moreover, little difference was observed between the cohorts within each severity grading and OHSS severity level incidence proportions were compatible with the background rate described in the literature (4,5).…”

“…Previously identified OHSS risk factors (3,4) that were confirmed to be associated with the incidence of OHSS in the SOFIA study include PCOS, having an embryo transfer, antral follicle count, basal serum AMH, FSH dose reduction, FSH treatment duration, and pregnancy. Other risk factors such as age and BMI were not found to be associated with OHSS, possibly due to the fact that a minority of the women were younger (<30 years) and/or had a low BMI.…”

Risk factors, management, and future fertility of empty follicle syndrome: a retrospective study with real-world data

“…An accidental hCG injection mistake, as seen in our study, can halt ovarian stimulation without triggering ovulation, which was similar to “coasting”. Previous studies showed that 1 to 2 days of “coasting” is harmless ( 22 , 23 ). Stevenson reported live births in six out of 14 similar cases after rescue hCG injection, suggesting that oocyte and embryo quality may not be compromised ( 24 ).…”

Follicular Aspiration Is Superior to Coasting as Effective Prophylactic Procedure against Ovarian Hyperstimulation Syndrome

“…Furthermore, about 75% of patients developed mild symptoms ranging between grade one and two. The obtained results concerning patients received coasting procedure are in line D'Angelo et al [23] who reviewed RCT assessed the effect of coasting on prevention of OHSS and reported lower rates of OHSS with coasting versus no coasting by rates suggesting that if 45% of women developed moderate or severe OHSS without coasting, only 4% -17% would develop it with coasting. Also, Abide Yayla et al [24] in their retrospective study of women used coasting to avoid OHSS in 100 high-risk women and documented that all women had reached to embryo transfer stage and reported clinical pregnancy rate of 44%.…”

Safety of Ovaleap® (Follitropin Alfa) in Infertile Women Undergoing Superovulation for Assisted Reproductive Technologies: A Multinational Comparative, Prospective Cohort Study

“…reported in the clinical development program of Ovaleap ® and in a post marketing study (9,10,13). Moreover, little difference was observed between the cohorts within each severity grading and OHSS severity level incidence proportions were compatible with the background rate described in the literature (4,5).…”

“…Previously identified OHSS risk factors (3,4) that were confirmed to be associated with the incidence of OHSS in the SOFIA study include PCOS, having an embryo transfer, antral follicle count, basal serum AMH, FSH dose reduction, FSH treatment duration, and pregnancy. Other risk factors such as age and BMI were not found to be associated with OHSS, possibly due to the fact that a minority of the women were younger (<30 years) and/or had a low BMI.…”

Risk factors, management, and future fertility of empty follicle syndrome: a retrospective study with real-world data

“…An accidental hCG injection mistake, as seen in our study, can halt ovarian stimulation without triggering ovulation, which was similar to “coasting”. Previous studies showed that 1 to 2 days of “coasting” is harmless ( 22 , 23 ). Stevenson reported live births in six out of 14 similar cases after rescue hCG injection, suggesting that oocyte and embryo quality may not be compromised ( 24 ).…”