Coassembly of amphiphilic peptide EAK16-II with histidinylated analogues and implications for functionalization of β-sheet fibrils in vivo

Wen, Yi; Roudebush, Shana L.; Buckholtz, Gavin A.; Goehring, Thomas R.; Giannoukakis, Nick; Gawalt, Ellen S.; Meng, Wilson S.

doi:10.1016/j.biomaterials.2014.03.009

Cited by 68 publications

(70 citation statements)

References 28 publications

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“…When the RGD motif specifically recognized integrin α v β 3 on the cancer stem cells, the liposomes were drawn into closer contact with the cell surface, which enhanced the possibility of the R8 domain exerting the penetrating effect. 28,44 The enhanced internalization into brain cancer stem cells would contribute to improve the therapeutic effects both in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

Multifunctional Tandem Peptide Modified Paclitaxel-Loaded Liposomes for the Treatment of Vasculogenic Mimicry and Cancer Stem Cells in Malignant Glioma

Liu

Mei

et al. 2015

ACS Appl. Mater. Interfaces

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The chemotherapy of aggressive glioma is usually accompanied by a poor prognosis because of the formation of vasculogenic mimicry (VM) and brain cancer stem cells (BCSCs). VM provided a transporting pathway for nutrients and blood to the extravascular regions of the tumor, and BCSCs were always related to drug resistance and the relapse of glioma. Thus, it is important to evaluate the inhibition effect of antiglioma drug delivery systems on both VM and BCSCs. In this study, paclitaxel-loaded liposomes modified with a multifunctional tandem peptide R8-c(RGD) (R8-c(RGD)-Lip) were used for the treatment of glioma. An in vitro cellular uptake study proved the strongest targeting ability to be that of R8-c(RGD)-Lip to glioma stem cells. Drug loaded R8-c(RGD)-Lip exhibited an efficient antiproliferation effect on BCSCs and could induce the destruction of VM channels in vitro. The following pharmacodynamics study demonstrated that R8-c(RGD)-modified drug-loaded liposomes achieved both anti-VM and anti-BCSC effects in vivo. Finally, no significant cytotoxicity of the blood system or major organs of the drug-loaded liposomes was observed under treatment dosage in the safety evaluation. In conclusion, all of the results proved that R8-c(RGD)-Lip was a safe and efficient antiglioma drug delivery system.

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Section: Discussionmentioning

confidence: 99%

Multifunctional Tandem Peptide Modified Paclitaxel-Loaded Liposomes for the Treatment of Vasculogenic Mimicry and Cancer Stem Cells in Malignant Glioma

Liu

Mei

et al. 2015

ACS Appl. Mater. Interfaces

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“…34,35 The ionic-complementary self-assembled peptides have been used to enhance various types of cell growth and differentiation, including bone, cartilage, vessel, heart, and neural systems. 34,36 For example, the self-assembled peptide scaffolds made of RADA16-I and RADA16-II peptides have been used to enhance neural cell attachment, differentiation, and neurite outgrowth during in vitro studies, as well as to promote active synapse formation during in vivo studies. 33 For example, Gelain et al studied the 3D cultures of mouse neural stem cells using the self-assembling peptide RADA16 with the functionalized sequences derived from neural cell adhesion motifs, bone marrow homing proteins, and collagen molecules.…”

Section: Amphiphilic Peptidesmentioning

confidence: 99%

Self-assembled peptide nanomaterials for biomedical applications: promises and pitfalls

Sun

Zheng²,

Webster³

2016

IJN

151

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“…Recently, many self-assembly nanostructures have been synthesized from biomaterials including carbohydrates, nucleic acids, and peptides to achieve a better understanding of the self-assembly mechanism and utilize them for several biomedical applications such as tissue regeneration, drug delivery, and biosensors [12][13][14][15][16][17]. Many self-assembling systems have been developed for various biomedical applications; peptide self-assembled nanostructures remain one of the most promising directions for many reasons [18].…”

Section: Introductionmentioning

confidence: 99%

Peptide Self-Assembled Nanostructures for Drug Delivery Applications

Fan

Shen

et al. 2017

Journal of Nanomaterials

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Peptide self-assembled nanostructures are very popular in many biomedical applications. Drug delivery is one of the most promising applications among them. The tremendous advantages for peptide self-assembled nanostructures include good biocompatibility, low cost, tunable bioactivity, high drug loading capacities, chemical diversity, specific targeting, and stimuli responsive drug delivery at disease sites. Peptide self-assembled nanostructures such as nanoparticles, nanotubes, nanofibers, and hydrogels have been investigated by many researchers for drug delivery applications. In this review, the underlying mechanisms for the self-assembled nanostructures based on peptides with different types and structures are introduced and discussed. Peptide self-assembled nanostructures associated promising drug delivery applications such as anticancer drug and gene drug delivery are highlighted. Furthermore, peptide self-assembled nanostructures for targeted and stimuli responsive drug delivery applications are also reviewed and discussed.

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Coassembly of amphiphilic peptide EAK16-II with histidinylated analogues and implications for functionalization of β-sheet fibrils in vivo

Cited by 68 publications

References 28 publications

Multifunctional Tandem Peptide Modified Paclitaxel-Loaded Liposomes for the Treatment of Vasculogenic Mimicry and Cancer Stem Cells in Malignant Glioma

Multifunctional Tandem Peptide Modified Paclitaxel-Loaded Liposomes for the Treatment of Vasculogenic Mimicry and Cancer Stem Cells in Malignant Glioma

Self-assembled peptide nanomaterials for biomedical applications: promises and pitfalls

Peptide Self-Assembled Nanostructures for Drug Delivery Applications

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