Coagulase-negative staphylococcal bacteremia. Mortality and hospital stay

Martin, Michael A.; Pfaller, Michael A.; Wenzel, R. P.

doi:10.1016/0196-6553(90)90211-a

Cited by 82 publications

(116 citation statements)

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“…Although others have reported S. epidermidis to be the most common species of CNS isolated from the blood of neonates with suspected late-onset septicaemia (Martin et al, 1989;Freeman et al, 1987), we found that S. haemolyticus was the commonest, followed by S. epidermidis, in accordance with the study done by Mehta et al (1991). This was also true for the skin CNS isolates, and the antimicrobial resistance pattern of CNS isolated from the two sources was similar.…”

Section: Resultssupporting

confidence: 80%

Prevalence of methicillin-resistant, coagulase-negative staphylococci in neonatal intensive care units: findings from a tertiary care hospital in India

Jain

Agarwal

Bansal

2004

Journal of Medical Microbiology

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This study was undertaken to determine the antimicrobial resistance pattern and species of coagulase-negative staphylococci (CNS) isolated from the blood and skin of neonates with clinical suspicion of late-onset septicaemia (.72 h post-delivery) admitted to neonatal intensive care units, with particular reference to the phenotypic and genotypic expression of methicillin resistance. Blood culture specimens were collected by venipuncture from 660 such neonates in brain heart infusion broth. Skin swabs from axillae were obtained from 60 neonates and inoculated on mannitol salt agar. All CNS thus obtained were further identified and antibiotic sensitivity was performed according to NCCLS recommendations. PCR for the mecA gene was carried out on 54 randomly selected isolates. Staphylococcus haemolyticus was the commonest species (34 %) followed by Staphylococcus epidermidis (24 %) amongst blood isolates. All blood isolates were sensitive to glycopeptides. Resistance to penicillin and methicillin was 94 and 66 %, respectively. Similar biotypes and antimicrobial resistance patterns were observed in skin isolates. All phenotypically methicillin-resistant isolates had the mecA gene and two of the phenotypically methicillin-sensitive isolates were also positive for mecA. A PCR assay for detection of the mecA gene in CNS may be a beneficial adjunct to standard susceptibility testing for timely and reliable detection of methicillin resistance. Given the large number of methicillin-resistant CNS, inclusion of vancomycin in empiric therapy for neonates with late-onset septicaemia may be justified.

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Section: Resultssupporting

confidence: 80%

Prevalence of methicillin-resistant, coagulase-negative staphylococci in neonatal intensive care units: findings from a tertiary care hospital in India

Jain

Agarwal

Bansal

2004

Journal of Medical Microbiology

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“…Archer & Climo (1994) indicated that the percentage of CNS resistant to meticillin, oxacillin and nafcillin amongst HAI strains increased from 20 to 60% between 1980 and 1989, according to The National Nosocomial Infection Survey, which included data collected from selected hospitals in the USA. An even larger increase was reported at university hospitals in the state of Iowa, where the frequency of bacteraemia caused by CNS increased from 5.2 to 42 cases per 10 000 admissions from 1984 to 1987 (Martin et al, 1989). Simultaneously, the widest spectrum of antimicrobial resistance amongst CNS was observed in S. haemolyticus strains.…”

Section: Multiresistancementioning

confidence: 78%

Staphylococcus haemolyticus – an emerging threat in the twilight of the antibiotics age

2015

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“…Of the 42 plasmid types identified, five types (Nos. [1][2][3][4][5] comprised 56 (50%) of the isolates, whereas each of the remaining 37 types was unique to a single isolate ( Table 3). The predominant plasmid pattern (type 2) was found only in S. epidermidis of biochemical type 4, comprising 64 % of such isolates.…”

Section: Drcns Typesmentioning

confidence: 99%

“…Coagulase-negative staphylococci (CNS) belonging to the normal skin flora of humans today cause a wide range of hospital-acquired infections with increasing morbidity and mortality [1]. Staphylococcus epidermidis is the predominant species, accounting for 80-96 % of CNS infections, but S. haemolyticus, S. warneri, S. cohnii, S. capitis, S. simulans, S. xylosus, or S. hominis may also be involved [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Drug-resistant coagulase-negative skin staphylococci: Evaluation of four marker systems and epidemiology in an orthopaedic ward

Thore

Kühn²,

Löfdahl³

et al. 1990

Epidemiol. Infect.

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SUMMARYDrug-resistant coagulase-negative staphylococci (DRCNS) in orthopaedic patients and ward staff were studied. A significant increase in the DRCNS carriage rate was observed among the 16 patients studied after 14 days of hospitalization with levels approaching that of the staff. Patients receiving dicloxacillin prophylaxis (n = 9) were more likely to be colonized with methicillin-resistant CNS, while patients receiving no antibiotics (n = 7) became to a larger extent colonized with multiple DRCNS. The combined data from species determination, biochemical, plasmid, and antibiogram typing revealed a considerable diversity among DRCNS; 64 types were distinguished among 112 DRCNS isolates selected for study after exclusion of apparently duplicate isolates. Plasmid plus antibiogram typing yielded almost as many types (61); whereas species determination plus antibiogram distinguished only 33 types. Although a novel computerized 96-reaction boityping method alone enabled differentiation of 17 biotypes, most DRCNS isolates belonged to one of three major biotypes limiting the usefulness of this method. Ten of the 64 (16%) DRCNS types identified comprised 50 of the 112 (45%) isolates. These were isolated from staff and from patients on day 14, suggesting a nosocomial origin.

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Coagulase-negative staphylococcal bacteremia. Mortality and hospital stay

Cited by 82 publications

References 0 publications

Prevalence of methicillin-resistant, coagulase-negative staphylococci in neonatal intensive care units: findings from a tertiary care hospital in India

Prevalence of methicillin-resistant, coagulase-negative staphylococci in neonatal intensive care units: findings from a tertiary care hospital in India

Staphylococcus haemolyticus – an emerging threat in the twilight of the antibiotics age

Drug-resistant coagulase-negative skin staphylococci: Evaluation of four marker systems and epidemiology in an orthopaedic ward

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